scholarly journals Postnatal hydrocortisone treatment for chronic lung disease in the preterm newborn and long-term neurodevelopmental follow-up

2008 ◽  
Vol 93 (1) ◽  
pp. F58-F63 ◽  
Author(s):  
K J Rademaker ◽  
L S de Vries ◽  
C S P M Uiterwaal ◽  
F Groenendaal ◽  
D E Grobbee ◽  
...  
Keyword(s):  
Lung Disease ◽  
Chronic Lung Disease ◽  
Preterm Newborn ◽  
Hydrocortisone Treatment

Long-term follow-up of chronic lung disease of infancy

2004 ◽  
Vol 37 (S26) ◽  
pp. 106-107 ◽  
Author(s):  
Teresa Bandeira ◽  
Teresa Nunes
Keyword(s):  
Lung Disease ◽  
Chronic Lung Disease ◽  
Long Term Follow Up

Airway function measurements and the long-term follow-up of survivors of preterm birth with and without chronic lung disease

2006 ◽  
Vol 41 (6) ◽  
pp. 497-508 ◽  
Author(s):  
Indra Narang ◽  
Eugenio Baraldi ◽  
Michael Silverman ◽  
Andrew Bush
Keyword(s):  
Preterm Birth ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Airway Function ◽  
Long Term Follow Up

scholarly journals Early Changes and Indicators Characterizing Lung Aging in Neonatal Chronic Lung Disease

2021 ◽  
Vol 8 ◽  
Author(s):  
Jennifer Sucre ◽  
Lena Haist ◽  
Charlotte E. Bolton ◽  
Anne Hilgendorff
Keyword(s):  
Lung Disease ◽  
Chronic Lung Disease ◽  
Health Care Professionals ◽  
Treatment Strategies ◽  
Oxygen Toxicity ◽  
Growth Factor Signaling ◽  
Inflammatory Processes ◽  
Long Term Consequences ◽  
Neonatal Chronic Lung Disease

Infants suffering from neonatal chronic lung disease, i.e., bronchopulmonary dysplasia, are facing long-term consequences determined by individual genetic background, presence of infections, and postnatal treatment strategies such as mechanical ventilation and oxygen toxicity. The adverse effects provoked by these measures include inflammatory processes, oxidative stress, altered growth factor signaling, and remodeling of the extracellular matrix. Both, acute and long-term consequences are determined by the capacity of the immature lung to respond to the challenges outlined above. The subsequent impairment of lung growth translates into an altered trajectory of lung function later in life. Here, knowledge about second and third hit events provoked through environmental insults are of specific importance when advocating lifestyle recommendations to this patient population. A profound exchange between the different health care professionals involved is urgently needed and needs to consider disease origin while future monitoring and treatment strategies are developed.

The Use of Dexamethasone in Premature Infants at Risk for Bronchopulmonary Dysplasia or Who Already Have Developed Chronic Lung Disease: A Cautionary Note

PEDIATRICS ◽  
1991 ◽  
Vol 88 (2) ◽  
pp. 414-415
Author(s):  
KENNETH L. HARKAVY
Keyword(s):  
Lung Disease ◽  
Chronic Lung Disease ◽  
Meta Analysis ◽  
Cautionary Note ◽  
Short Treatment ◽  
Treatment Regimens ◽  
Length Of Treatment ◽  
Term Benefit ◽  
Combined Data

In Reply.— The letter-to-the-editor from Dr Frank is a cautionary note about the risks of glucocorticoid therapy for chronic lung disease in infants. These concerns are real and have been enumerated in most papers on the subject. Only one study to date has suggested a long-term benefit (decreased mortality); yet consistently respiratory therapy support is decreased by steroid use. I have performed a limited meta-analysis because all studies have had similar enrollment criteria and treatment regimens. Two lengths of treatment have been compared and the combined data compared with the controls (Table 1). [See table in the PDF file] This analysis suggests that there is no major difference in outcome by length of treatment, although short treatment was associated with less hyperglycemia and longer duration of intubation. Comparison of all steroid-treated patients with placebo-treated babies showed treated infants had more hyperglycemia (P < .01 χ2) but an average of 11 fewer days of mechanical ventilation (intermittent mandatory ventilation, ImV). (t test was not done due to lack of raw data; however, difference was significant in each subgroup.)

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