Novel conformationally locked nucleosides and oligonucleotides based on bicyclo[3.2.1]octane scaffold as a pseudosugar moiety

2014 ◽  
Author(s):  
Michal Šála ◽  
Milan Dejmek ◽  
Eliška Procházková ◽  
Hubert Hřebabecký ◽  
Jiří Rybáček ◽  
...  
Keyword(s):  
Conformationally Locked

New conformationally locked bicyclic N,O-nucleoside analogues of antiviral drugs

2005 ◽  
Vol 15 (3) ◽  
pp. 545-550 ◽  
Author(s):  
Antonio Procopio ◽  
Stefano Alcaro ◽  
Antonio De Nino ◽  
Loredana Maiuolo ◽  
Francesco Ortuso ◽  
...  
Keyword(s):  
Antiviral Drugs ◽  
Nucleoside Analogues ◽  
Conformationally Locked

Conformationally locked nucleosides. Synthesis and stereochemical assignments of 2′-C,4′-C-bridged bicyclonucleosides

Tetrahedron ◽  
1999 ◽  
Vol 55 (25) ◽  
pp. 7707-7724 ◽  
Author(s):  
Guangyi Wang ◽  
Jean-Luc Girardet ◽  
Esmir Gunic
Keyword(s):  
Conformationally Locked

Lability of Stationary and Time-Resolved Optical Properties of the Conformationally Locked CFP Chromophore Derivative

2021 ◽  
Vol 47 (3) ◽  
pp. 784-787
Author(s):  
A. M. Bogdanov ◽  
D. A. Gorbachev ◽  
E. R. Zaitseva ◽  
A. Yu. Smirnov ◽  
N. S. Baleeva ◽  
...  
Keyword(s):  
Optical Properties ◽  
Time Resolved ◽  
Conformationally Locked

scholarly journals The Chemoselective Reduction of Isoxazolineγ-Lactams Through Iminium Aza-Diels-Alder Reactions: A Short-Cut Synthesis of Aminols as Valuable Intermediates towards Nucleoside Derivatives

2012 ◽  
Vol 2012 ◽  
pp. 1-10
Author(s):  
Misal Giuseppe Memeo ◽  
Mariella Mella ◽  
Paolo Quadrelli
Keyword(s):  
Catalytic Oxidation ◽  
Ring Opening ◽  
Diels Alder ◽  
Mild Conditions ◽  
Nucleoside Synthesis ◽  
Conformationally Locked

Isoxazolineγ-lactams are prepared starting from the regioisomeric cycloadducts of benzonitrile oxide to theN-alkyl 2-azanorbornenes taking advantage of the efficient catalytic oxidation by RuO4. The reduction of the amide groups is easily conducted in the presence of LiAlH4under mild conditions, which allowed for the chemoselective reduction of the amide moiety followed by ring opening to afford the desired conformationally locked isoxazoline-carbocyclic aminols, as valuable intermediates for nucleoside synthesis.

Synthesis of a conformationally locked AZT analogue, 3′-azido-3′-deoxy-2′-O,4′-C-methylene-5-methyluridine

1999 ◽  
Vol 40 (35) ◽  
pp. 6465-6468 ◽  
Author(s):  
Satoshi Obika ◽  
Jun-ichi Andoh ◽  
Tomomi Sugimoto ◽  
Kazuyuki Miyashita ◽  
Takeshi Imanishi
Keyword(s):  
Conformationally Locked

Synthesis of oligodeoxyribonucleotides containing a conformationally-locked anti analogue of O6-methyl-2′-deoxyguanosine and their recognition by MGMT and Atl1

2012 ◽  
Vol 48 (91) ◽  
pp. 11214 ◽  
Author(s):  
Kabir Abdu ◽  
Miren K. Aiertza ◽  
Oliver J. Wilkinson ◽  
Jane A. Grasby ◽  
Pattama Senthong ◽  
...  
Keyword(s):  
Conformationally Locked
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