Phosphanucleosides containing 1-hydroxymethylphospholane 1-oxide ring

2014 ◽  
Author(s):  
Ondřej Páv ◽  
Eva Zborníková ◽  
Miloš Buděšínský ◽  
Ivan Rosenberg
Keyword(s):  
Oxide Ring

Quinoxaline 1,4-di-N-Oxide Derivatives: Are They Unselective or Selective Inhibitors?

2021 ◽  
Vol 21 ◽  
Author(s):  
Gildardo Rivera
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Cell Lines ◽  
Mechanism Of Action ◽  
Inhibitory Action ◽  
Triosephosphate Isomerase ◽  
Trypanothione Reductase ◽  
Selective Inhibitors ◽  
Oxide Ring ◽  
Privileged Structure

Background: For decades, the quinoxaline 1,4-di-N-oxide ring has been considered a privileged structure to develop new antibacterial, antitumoural, and antiprotozoal agents, among others, however its mechanism of action is not clear. Objective : The main aim of this mini-review was to analyze the mechanism of action of quinoxaline 1,4-di-N-oxide derivatives reported as antibacterial, antitumoural and antiprotozoal agents. Results : Initially, the mechanism of action of quinoxaline 1,4-di-N-oxide derivatives against bacteria, tumoural cell lines, and parasites has been described as nonspecific, but recently, the results against different organisms have shown that these compounds have an inhibitory action on specific targets such as trypanothione reductase, triosephosphate isomerase, and other essential enzymes. Conclusion: In summary, quinoxaline 1,4-di-N-oxide is a scaffold to develop new anti-Mycobacterium tuberculosis, antitumoural and antiprotozoal agents, however, understanding the mechanism of action of quinoxaline 1,4-di-N-oxide derivatives in each microorganism could contribute to the development of new, and more potent selective drugs.

Migration of ?-oxide ring in erythro-3,4-butanediol 1,2-oxide 4-nitrate

1973 ◽  
Vol 22 (7) ◽  
pp. 1608-1610
Author(s):  
L. T. Eremenko ◽  
G. V. Lagodzinskaya ◽  
A. M. Korolev
Keyword(s):  
Oxide Ring

ChemInform Abstract: Formation of a Pyrroline N-Oxide Ring by Reaction of Isonitrosoketones with Enamines and Some Reactions of the Synthesized Pyrroline N-Oxides.

ChemInform ◽  
2010 ◽  
Vol 28 (4) ◽  
pp. no-no
Author(s):  
V. A. SAMSONOV ◽  
L. B. VOLODARSKII ◽  
I. YU. BAGRYANSKAYA ◽  
YU. V. GATILOV
Keyword(s):  
Oxide Ring

Investigation of Copper Oxide Ring Formation during Post Chemical Mechanical Polishing Cleaning of Cu Interconnect

2017 ◽  
Vol 6 (8) ◽  
pp. P542-P546 ◽  
Author(s):  
Hojoong Kim ◽  
Seokjun Hong ◽  
Yinhua Jin ◽  
Dong Hyun Lim ◽  
Jun-yong Kim ◽  
...  
Keyword(s):  
Copper Oxide ◽  
Chemical Mechanical Polishing ◽  
Ring Formation ◽  
Mechanical Polishing ◽  
Oxide Ring ◽  
Cu Interconnect

scholarly journals Internal Dynamics of the 3-Pyrroline-N-Oxide Ring in Spin-Labeled Proteins

2017 ◽  
Vol 8 (6) ◽  
pp. 1113-1117 ◽  
Author(s):  
Philipp Consentius ◽  
Bernhard Loll ◽  
Ulrich Gohlke ◽  
Claudia Alings ◽  
Carsten Müller ◽  
...  
Keyword(s):  
Internal Dynamics ◽  
Oxide Ring
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