Is nitric oxide involved in the antinociceptive effects of kyotorphin, Tyr-Cav and MIF's analogues in rats?

2003 ◽  
Author(s):  
Adriana Bocheva ◽  
Elena Dzambazova ◽  
Tamara I. Pajpanova
Keyword(s):  
Nitric Oxide ◽  
Antinociceptive Effects

Roles of Nitric Oxide Synthase inhibitor on Antinociceptive Effects of μ-Opioid Agonist in Mice

2006 ◽  
Vol 13 (10) ◽  
pp. 993-997 ◽  
Author(s):  
Li-Xiang Chen ◽  
Yuan-Ming Qi ◽  
Rui Wang ◽  
Xin Duan ◽  
Yan-Feng Gao ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Opioid Agonist ◽  
Nitric Oxide Synthase Inhibitor ◽  
Antinociceptive Effects ◽  
Synthase Inhibitor ◽  
Oxide Synthase

scholarly journals 159 THE ANTINOCICEPTIVE EFFECTS OF GABAPENTIN AND NITRIC OXIDE ON NEUROPATHIC PAIN MODEL FORMED IN RATS

2010 ◽  
Vol 4 (S1) ◽  
pp. 48-48
Author(s):  
F. Sekdur ◽  
O.N. Aydin ◽  
B. Alacam ◽  
M. Ogurlu ◽  
S. Temocin ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Neuropathic Pain ◽  
Pain Model ◽  
Antinociceptive Effects ◽  
Neuropathic Pain Model

scholarly journals The Antinociceptive Effects of JWH-015 in Chronic Inflammatory Pain Are Produced by Nitric Oxide-cGMP-PKG-KATP Pathway Activation Mediated by Opioids

PLoS ONE ◽  
2011 ◽  
Vol 6 (10) ◽  
pp. e26688 ◽  
Author(s):  
Roger Negrete ◽  
Arnau Hervera ◽  
Sergi Leánez ◽  
Jesús M. Martín-Campos ◽  
Olga Pol
Keyword(s):  
Nitric Oxide ◽  
Inflammatory Pain ◽  
Chronic Inflammatory Pain ◽  
Pathway Activation ◽  
Antinociceptive Effects

Treatment with Carbon Monoxide-releasing Molecules and an HO-1 Inducer Enhances the Effects and Expression of µ-Opioid Receptors during Neuropathic Pain

2013 ◽  
Vol 118 (5) ◽  
pp. 1180-1197 ◽  
Author(s):  
Arnau Hervera ◽  
Sergi Leánez ◽  
Roberto Motterlini ◽  
Olga Pol
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Neuropathic Pain ◽  
Sciatic Nerve ◽  
Nerve Injury ◽  
Heme Oxygenase ◽  
Opioid Receptors ◽  
Nitric Oxide Synthases ◽  
Antinociceptive Effects ◽  
Inducible Nitric Oxide

Abstract Background: The administration of µ-opioid receptors (MOR) and δ-opioid receptors (DOR) as well as cannabinoid-2 receptor (CB2R) agonists attenuates neuropathic pain. We investigated if treatment with two carbon monoxide-releasing molecules (CORM-2 and CORM-3) or an inducible heme oxygenase inducer (cobalt protoporphyrin IX, CoPP) could modulate the local and systemic effects and expression of MOR, DOR, and CB2R during neuropathic pain. Methods: In C57BL/6 mice, at 10 days after the chronic constriction of sciatic nerve, we evaluated the effects of the intraperitoneal administration of 10 mg/kg of CORM-2, CORM-3, or CoPP on the antiallodynic and antihyperalgesic actions of a locally or systemically administered MOR (morphine), DOR ([d-Pen(2),d-Pen(5)]-enkephalin) or CB2R ((2-methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone ) agonist. The effects of CORM-2 and CoPP treatments on the expression of MOR, DOR, CB2R, inducible and constitutive heme oxygenases, microglia activation marker (CD11b/c), and neuronal and inducible nitric oxide synthases were also assessed. Results: Treatments with CO-RMs and CoPP reduced the mechanical and thermal hypersensitivity induced by sciatic nerve injury, increased the local, but not systemic, antinociceptive effects of morphine, and decreased those produced by DPDPE and JWH-015. Both CORM-2 and CoPP treatments enhanced MOR and inducible heme oxygenase expression, unaltered DOR and constitutive heme oxygenase expression, and decreased the overexpression of CB2R, CD11b/c, and neuronal and inducible nitric oxide synthases induced by sciatic nerve injury. Conclusions: This study shows that CO-RMs and CoPP treatments increase the local antinociceptive effects of morphine through enhancing MOR peripheral expression and inhibiting spinal microglial activation and overexpression of neuronal/inducible nitric oxide synthases.

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