The synthesis of phosphonamidate and phosphinic dipeptide analogues - Inhibitors of leucine aminopeptidase

2001 ◽  
Author(s):  
Artur Mucha ◽  
Jolanta Grembecka ◽  
Tomasz Cierpicki ◽  
Paweł Kafarski
Keyword(s):  
Leucine Aminopeptidase ◽  
Dipeptide Analogues

Structure-Based Design and Synthesis of Dipeptide Analogues as New Inhibitors of Leucine Aminopeptidase

2002 ◽  
Vol 177 (6-7) ◽  
pp. 1739-1743 ◽  
Author(s):  
Jolanta Grembecka ◽  
Artur Mucha ◽  
Tomasz Cierpicki ◽  
Paweł Kafarski
Keyword(s):  
Leucine Aminopeptidase ◽  
Design And Synthesis ◽  
Dipeptide Analogues

Quantification of small-scale heterogeneity in aquatic aminopeptidase activity

2020 ◽  
Vol 84 ◽  
pp. 127-140
Author(s):  
BM Gaas ◽  
JW Ammerman
Keyword(s):  
Chlorophyll Fluorescence ◽  
Leucine Aminopeptidase ◽  
Hudson River ◽  
Aminopeptidase Activity ◽  
Small Scale ◽  
Analysis Instrument ◽  
Sequential Samples ◽  
Degree Of Confidence ◽  
The Mean ◽  
Hydrolysis Of

Leucine aminopeptidase (LAP) is one of the enzymes involved in the hydrolysis of peptides, and is sometimes used to indicate potential nitrogen limitation in microbes. Small-scale variability has the potential to confound interpretation of underlying patterns in LAP activity in time or space. An automated flow-injection analysis instrument was used to address the small-scale variability of LAP activity within contiguous regions of the Hudson River plume (New Jersey, USA). LAP activity had a coefficient of variation (CV) of ca. 0.5 with occasional values above 1.0. The mean CVs for other biological parameters—chlorophyll fluorescence and nitrate concentration—were similar, and were much lower for salinity. LAP activity changed by an average of 35 nmol l-1 h-1 at different salinities, and variations in LAP activity were higher crossing region boundaries than within a region. Differences in LAP activity were ±100 nmol l-1 h-1 between sequential samples spaced <10 m apart. Variogram analysis indicated an inherent spatial variability of 52 nmol l-1 h-1 throughout the study area. Large changes in LAP activity were often associated with small changes in salinity and chlorophyll fluorescence, and were sensitive to the sampling frequency. This study concludes that LAP measurements in a sample could realistically be expected to range from zero to twice the average, and changes between areas or times should be at least 2-fold to have some degree of confidence that apparent patterns (or lack thereof) in activity are real.

Muramyl-dipeptide analogues: Synthesis and biological activities

1988 ◽  
Vol 53 (11) ◽  
pp. 2897-2906 ◽  
Author(s):  
Jan Ježek ◽  
Milan Zaoral ◽  
Miloš Buděšínský ◽  
Jiří Günther ◽  
Jiří Rotta
Keyword(s):  
Biological Activities ◽  
Muramyl Dipeptide ◽  
Delayed Hypersensitivity ◽  
Test Compound ◽  
Active Compounds ◽  
Dipeptide Analogues ◽  
Pyrogenic Activity

In the search for immunoadjuvant active compounds without pyrogenic activity we prepared N-Ac-norMur-L-Abu-D-Gln-O-Bu (V), N-Ac-Mur-L-Abu-D-Gln-O-Bu (VII) and their respective α-benzylglycosides VI and VIII. All the prepared compounds are nonpyrogenic. In the delayed hypersensitivity test, compound V is inactive, VI is comparable to MDP, VII is more and VIII is less active than MDP.

scholarly journals THE SPECIFICITY OF LEUCINE AMINOPEPTIDASE

1949 ◽  
Vol 180 (3) ◽  
pp. 1209-1223
Author(s):  
Emil L. Smith ◽  
W.J. Polglase
Keyword(s):  
Leucine Aminopeptidase

Construction of a novel asymmetric imidazole-cored AIE probe for ratiometric imaging of endogenous leucine aminopeptidase

2021 ◽  
Author(s):  
Xueyan Huang ◽  
Qian Lei ◽  
Shuai Huang ◽  
Hongliang Zeng ◽  
Bin Feng ◽  
...  
Keyword(s):  
Leucine Aminopeptidase ◽  
Aminopeptidase P ◽  
Ratiometric Imaging

We reported a rational strategy to deliberately construct the first asymmetric tetraarylimidazole-based AIE probe, integrating AIE behavior in synergy with ESIPT character to ratiometric imaging of endogenous LAP for the...

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