Interaction and micellar solubilization of diclofenac with cetyltrimethylammonium bromide: A spectrophotometric study

2009 ◽  
Vol 74 (3) ◽  
pp. 503-513 ◽  
Author(s):  
Reza Hosseinzadeh ◽  
Mohammad Gheshlagi
Keyword(s):  
Partition Coefficient ◽  
Micellar Solution ◽  
Cetyltrimethylammonium Bromide ◽  
Binding Constants ◽  
Spectrophotometric Study ◽  
Bulk Water ◽  
Micellar Solubilization ◽  
Cationic Micelles ◽  
Drug Concentrations ◽  
Aqueous Micellar Solution

In this study, the interaction of diclofenac (Dic) with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on solubilization of diclofenac in aqueous micellar solution was studied at pH 6.8, 29 °C and various drug concentrations. The binding of diclofenac to CTAB micelles was accompanied by a batochromic shift in the drug absorption spectra. The solubility of diclofenac increased with increasing surfactant concentration as a consequence of the association between the drug and micelles. From the results, the binding constants Kb, was obtained. By using the pseudo-phase model, the partition coefficient between the bulk water and CTAB micelles, Kx, and the Gibbs energy of binding were calculated. The value of binding constant and partition coefficient are increased by increasing of diclofenac concentration.

scholarly journals Spectrophotometric study of interaction and solubilization of procaine hydrochloride in micellar systems

2009 ◽  
Vol 7 (1) ◽  
pp. 90-95 ◽  
Author(s):  
Reza Hosseinzadeh ◽  
Mohammad Gheshlagi ◽  
Rahele Tahmasebi ◽  
Farnaz Hojjati
Keyword(s):  
Electrostatic Interactions ◽  
Hydrophobic Interactions ◽  
Sodium Dodecyl ◽  
Spectrophotometric Study ◽  
Bulk Water ◽  
Procaine Hydrochloride ◽  
Ionic Surfactants ◽  
Micellar Systems ◽  
Aqueous Micellar Solution ◽  
Triton X

AbstractThe interaction of Procaine hydrochloride (PC) with cationic, anionic and non-ionic surfactants; cetyltrimethylammonium bromide (CTAB), sodium dodecyl sulfate (SDS) and triton X-100, were investigated. The effect of ionic and non-ionic micelles on solubilization of Procaine in aqueous micellar solution of SDS, CTAB and triton X-100 were studied at pH 6.8 and 29°C using absorption spectrophotometry. By using pseudo-phase model, the partition coefficient between the bulk water and micelles, Kx, was calculated. The results showed that the micelles of CTAB enhanced the solubility of Procaine higher than SDS micelles (Kx = 96 and 166 for SDS and CTAB micelles, respectively) but triton X-100 did not enhanced the solubility of drug because of weak interaction with Procaine. From the resulting binding constant for Procaine-ionic surfactants interactions (Kb = 175 and 128 for SDS and CTAB surfactants, respectively), it was concluded that both electrostatic and hydrophobic interactions affect the interaction of surfactants with cationic procaine. Electrostatic interactions have a great role in the binding and consequently distribution of Procaine in micelle/water phases. These interactions for anionic surfactant (SDS) are higher than for cationic surfactant (CTAB). Gibbs free energy of binding and distribution of procaine between the bulk water and studied surfactant micelles were calculated.

scholarly journals Kinetics and Mechanism of Nanoparticles-Catalyzed Piperidinolysis of Anionic Phenyl Salicylate

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Norazizah Abd. Razak ◽  
M. Niyaz Khan
Keyword(s):  
Rate Constants ◽  
Binding Constant ◽  
Cetyltrimethylammonium Bromide ◽  
Catalytic Effect ◽  
Binding Constants ◽  
Bulk Water ◽  
Kinetics And Mechanism ◽  
Water Phase ◽  
Phenyl Salicylate ◽  
Spherical Micelles

The values of the relative counterion (X) binding constantRXBr(=KX/KBr, whereKXandKBrrepresent cetyltrimethylammonium bromide, CTABr, micellar binding constants ofXv-(in non-spherical micelles),v=1,2, and Br−(in spherical micelles)) are 58, 68, 127, and 125 forXv−=1−, 12−, 2−, and22-, respectively. The values of 15 mM CTABr/[NavX] nanoparticles-catalyzed apparent second-order rate constants for piperidinolysis of ionized phenyl salicylate at 35°C are 0.417, 0.488, 0.926, and 0.891 M−1 s−1forNavX= Na1, Na21, Na2, and Na22, respectively. Almost entire catalytic effect of nanoparticles catalyst is due to the ability of nonreactive counterions,Xv-, to expel reactive counterions,3−, from nanoparticles to the bulk water phase.

scholarly journals Stabilization of [4Fe-4S] Ferredoxin Model Complex by a Combination of Hydrophobic Cholyl Group and the Specific NH···S Hydrogen Bond in Aqueous Micellar Solution

1997 ◽  
Vol 29 (11) ◽  
pp. 949-951 ◽  
Author(s):  
Norikazu Ueyama ◽  
Masahiro Inohara ◽  
Takafumi Ueno ◽  
Taka-aki Okamura ◽  
Akira Nakamura
Keyword(s):  
Hydrogen Bond ◽  
Micellar Solution ◽  
Aqueous Micellar Solution ◽  
Model Complex
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