Pyrrolo[2,3-d]pyrimidine β-L-Nucleosides Containing 7-Deazaadenine, 2-Amino-7-deazaadenine, 7-Deazaguanine, 7-Deazaisoguanine, and 7-Deazaxanthine

2006 ◽  
Vol 71 (7) ◽  
pp. 956-977 ◽  
Author(s):  
Frank Seela ◽  
Xiaohua Peng
Keyword(s):  
Antiviral Activity ◽  
Single Crystal ◽  
Rna Viruses ◽  
Cd Spectra ◽  
X Ray ◽  
Stereoselective Glycosylation ◽  
Dna And Rna

The synthesis and properties of 7-deazapurine β-L-nucleosides are described. The stereoselective glycosylation of the anions of 2-amino-6-chloro-7-deazapurines 9a, 9b or 6-chloro-7-deazapurines 13a, 13d with 3,5-di-O-(4-methylbenzoyl)-2-deoxy-α-L-erythro-pentofuranosyl chloride (8) furnished the β-L-2'-deoxyribonucleosides 1-4. The synthesis of β-L-ribonucleosides 5-7 used the Silyl-Hilbert-Johnson reaction (TMSOTf/BSA/MeCN) performed under Vorbrüggen conditions for the glycosylation of 7-halogenated 6-chloro-2-pivalamido-7-deazapurines 17b-17d with 1-O-acetyl-2,3,5-tri-O-benzoyl-L-ribofuranose (16). Single-crystal X-ray analyses were performed and CD spectra were measured to assign the configuration. The antiviral activity against selected DNA and RNA viruses is reported.

scholarly journals Carbon nanotubes supported tyrosinase in the synthesis of lipophilic hydroxytyrosol and dihydrocaffeoyl catechols with antiviral activity against DNA and RNA viruses

2015 ◽  
Vol 23 (17) ◽  
pp. 5345-5351 ◽  
Author(s):  
Giorgia Botta ◽  
Bruno Mattia Bizzarri ◽  
Adriana Garozzo ◽  
Rossella Timpanaro ◽  
Benedetta Bisignano ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Antiviral Activity ◽  
Rna Viruses ◽  
Dna And Rna

scholarly journals Isoxazolidine Conjugates of N3-Substituted 6-Bromoquinazolinones—Synthesis, Anti-Varizella-Zoster Virus, and Anti-Cytomegalovirus Activity

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1889 ◽  
Author(s):  
Magdalena Grabkowska-Drużyc ◽  
Graciela Andrei ◽  
Dominique Schols ◽  
Robert Snoeck ◽  
Dorota Piotrowska
Keyword(s):  
Antiviral Activity ◽  
Rna Viruses ◽  
Dipolar Cycloaddition ◽  
Wild Type ◽  
Varicella Zoster ◽  
Dna And Rna ◽  
Varizella Zoster Virus ◽  
Lymphocyte Cell ◽  
Lymphocyte Cell Line ◽  
Virus Strains

1,3-Dipolar cycloaddition of N-methyl C-(diethoxyphosphoryl) nitrone to N3-substituted 6-bromo-2-vinyl-3H-quinazolin-4-ones gave (3-diethoxyphosphoryl) isoxazolidines substituted at C5 with quinazolinones modified at N3. All isoxazolidine cycloadducts were screened for antiviral activity against a broad spectrum of DNA and RNA viruses. Several isoxazolidines inhibited the replication of both thymidine kinase wild-type and deficient (TK+ and TK−) varicella-zoster virus strains at EC50 in the 5.4–13.6 μΜ range, as well as human cytomegalovirus (EC50 = 8.9–12.5 μΜ). Isoxazolidines trans-11b, trans-11c, trans-11e, trans-11f/cis-11f, trans-11g, trans-11h, and trans-11i/cis-11i exhibited moderate cytostatic activity towards the human lymphocyte cell line CEM (IC50 = 9.6–17 μM).

scholarly journals Antiviral Activity of Benzotriazole Based Derivatives

2020 ◽  
Vol 14 (1) ◽  
pp. 83-98
Author(s):  
Paola Corona ◽  
Sandra Piras ◽  
Roberta Ibba ◽  
Federico Riu ◽  
Gabriele Murineddu ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Rna Viruses ◽  
Group Interest ◽  
Dna And Rna ◽  
Benzotriazole Derivatives

Background: For the last thirty years, the benzotriazole scaffold has been the object of our group interest and we have already presented some results on the antiviral activity of our compounds. Objective: In this article, we conclude the exploration of N-(4-(R-2H-benzo[d][1,2,3]triazol-2-yl)phenyl)-4-R’-benzamides and 1-(4-(R-2H-benzo[d][1,2,3]triazol-2-yl)phenyl)-3-R’-ureas by synthesizing further modified derivatives, in order to have more elements for SARs evaluation. Methods: Here, we reported the synthesis and the antiviral screening results of 38 newly synthesized benzotriazole derivatives against a panel of DNA and RNA viruses. We also analyse SARs in comparing these compounds with previously published benzotriazole analogues, taking stock of the situation. Results: Among the newly presented derivatives, compounds 17 and 18 were the most active with EC50 6.9 and 5.5 µM, respectively against Coxsackievirus B5 (CV-B5) and 20.5 and 17.5 µM against Poliovirus (Sb-1). Conclusion: we can conclude that N-(4-(2H-benzo[d] [1 - 3] triazol-2-yl)phenyl-R-amide is a good chemical scaffold for the development of new antiviral molecules.

scholarly journals Syntheses of Isoxazoline-Carbocyclic Nucleosides and Their Antiviral Evaluation: A Standard Protocol

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Paolo Quadrelli ◽  
Naiara Vazquez Martinez ◽  
Roberto Scrocchi ◽  
Antonino Corsaro ◽  
Venerando Pistarà
Keyword(s):  
Antiviral Activity ◽  
Rna Viruses ◽  
Carbocyclic Nucleosides ◽  
Standard Protocol ◽  
Dna And Rna ◽  
Biological Tests ◽  
Key Steps ◽  
The Way

The current synthesis of racemic purine and pyrimidine isoxazoline-carbocyclic nucleosides is reported, detailing the key-steps for standard and reliable preparations. Improved yields were obtained by the proper tuning of the single synthetic steps, opening the way for the preparation of a variety of novel compounds. Some of the obtained compounds were also evaluated against a wide variety of DNA and RNA viruses including HIV. No specific antiviral activity was observed in the cases at hand. Novel compounds were prepared for future biological tests.

scholarly journals Antiviral activity and its mechanism of guanine 7-N-oxide on DNA and RNA viruses derived from salmonid.

1985 ◽  
Vol 38 (11) ◽  
pp. 1581-1587 ◽  
Author(s):  
MASAHIDE HASOBE ◽  
MINEO SANEYOSHI ◽  
KIYOSHI ISONO
Keyword(s):  
Antiviral Activity ◽  
Rna Viruses ◽  
Dna And Rna

scholarly journals Synthesis of Chiral Helic[1]triptycene[3]arenes and Their Enantioselective Recognition towards Chiral Guests Containing Aminoindan Groups

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 536
Author(s):  
Jing Li ◽  
Ying Han ◽  
Chuan-Feng Chen
Keyword(s):  
Circular Dichroism ◽  
Single Crystal ◽  
Crystal Structures ◽  
Ammonium Salts ◽  
Cd Spectra ◽  
X Ray ◽  
Enantioselective Recognition ◽  
Single Crystal Structures ◽  
Recognition Ability ◽  
Circular Dichroïsm

Starting from the enantiopure precursors, a pair of chiral macrocyclic arenes named helic[1]triptycene[3]arenes were conveniently synthesized. The circular dichroism (CD) spectra of the enantiomeric macrocyclic arenes exhibited mirror images, and the X-ray single crystal structures confirmed their absolute conformations as well. Moreover, the macrocyclic arenes showed strong complexation with secondary ammonium and primary ammonium salts containing aminoindan groups. In particular, the chiral macrocyclic arenes exhibited enantioselective recognition ability towards the chiral secondary ammonium salts containing aminoindan groups with an enantioselective ratio up to 3.89.

Antiviral activity of hop constituents against a series of DNA and RNA viruses

2004 ◽  
Vol 61 (1) ◽  
pp. 57-62 ◽  
Author(s):  
V BUCKWOLD ◽  
R WILSON ◽  
A NALCA ◽  
B BEER ◽  
T VOSS ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Rna Viruses ◽  
Dna And Rna

Electron Microscopy of Shock Loaded Polycrystalline Beryllium

1974 ◽  
Vol 32 ◽  
pp. 506-507 ◽  
Author(s):  
J. M. Galbraith ◽  
L. E. Murr ◽  
A. L. Stevens
Keyword(s):  
Electron Microscopy ◽  
Wave Propagation ◽  
Structural Change ◽  
Single Crystal ◽  
Diffraction Pattern ◽  
Shock Loading ◽  
Slip Systems ◽  
Compression Tests ◽  
X Ray Diffraction ◽  
X Ray

Uniaxial compression tests and hydrostatic tests at pressures up to 27 kbars have been performed to determine operating slip systems in single crystal and polycrystal1ine beryllium. A recent study has been made of wave propagation in single crystal beryllium by shock loading to selectively activate various slip systems, and this has been followed by a study of wave propagation and spallation in textured, polycrystal1ine beryllium. An alteration in the X-ray diffraction pattern has been noted after shock loading, but this alteration has not yet been correlated with any structural change occurring during shock loading of polycrystal1ine beryllium.This study is being conducted in an effort to characterize the effects of shock loading on textured, polycrystal1ine beryllium. Samples were fabricated from a billet of Kawecki-Berylco hot pressed HP-10 beryllium.

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