Cyclic Dipeptides with 1-Aminocyclopropane-1-carboxylic Acid

1997 ◽  
Vol 62 (6) ◽  
pp. 941-947 ◽  
Author(s):  
Evžen Kasafírek ◽  
Jaroslav Moural ◽  
Jarmila Vinšová ◽  
Antonín Šturc ◽  
Jan Taimr
Keyword(s):  
Carboxylic Acid ◽  
Human Embryo ◽  
Antiproliferative Activity ◽  
Leukemia Cells ◽  
Cyclic Dipeptides ◽  
Embryo Cells ◽  
Normal Human

Cyclic dipeptides of the formula cyclo(-Acc-X-), where Acc = 1-aminocyclopropane-1-carboxylic acid, X = Gly, Ala, Val, Leu, Phe or Tyr, were synthesized. The prepared 2,5-piperazinediones showed no proliferative or antiproliferative activity on normal human embryo cells as well as on HL60 leukemia cells. Results of trace memory assays in mice were negative.

Characterization of normal human embryo cells grown to over 100 population doublings

In Vitro ◽  
1978 ◽  
Vol 14 (5) ◽  
pp. 405-412 ◽  
Author(s):  
J. A. Poiley ◽  
R. F. Schuman ◽  
R. J. Pienta
Keyword(s):  
Human Embryo ◽  
Embryo Cells ◽  
Normal Human ◽  
Population Doublings

Hypoxia Relieves X-Ray-Induced Delayed Effects in Normal Human Embryo Cells

2000 ◽  
Vol 154 (6) ◽  
pp. 659-666 ◽  
Author(s):  
Kanaklata Roy ◽  
Seiji Kodama ◽  
Keiji Suzuki ◽  
Kazuaki Fukase ◽  
Masami Watanabe
Keyword(s):  
Human Embryo ◽  
X Ray ◽  
Delayed Effects ◽  
Embryo Cells ◽  
Normal Human

Dose-Dependent Biphasic Accumulation of TP53 Protein in Normal Human Embryo Cells after X Irradiation

2000 ◽  
Vol 153 (3) ◽  
pp. 305-311 ◽  
Author(s):  
Jagadish C. Ghosh ◽  
Yuko Izumida ◽  
Keiji Suzuki ◽  
Seiji Kodama ◽  
Masami Watanabe
Keyword(s):  
Human Embryo ◽  
Embryo Cells ◽  
X Irradiation ◽  
Normal Human ◽  
Dose Dependent ◽  
Tp53 Protein

Spinal cord-notochord relationship in normal human embryos and in a human embryo with double spinal cord

1993 ◽  
Vol 86 (5) ◽  
Author(s):  
Mirna Saraga-Babi� ◽  
Vedran Stefanovi� ◽  
Jorma Wartiovaara ◽  
Eero Lehtonen
Keyword(s):  
Spinal Cord ◽  
Human Embryo ◽  
Human Embryos ◽  
Normal Human

Synthesis and antiproliferative activity of novel 4-azasteroidal-17-hydrazone derivatives

2019 ◽  
Vol 43 (3-4) ◽  
pp. 130-134
Author(s):  
Shao-Rui Chen ◽  
Hao Wu ◽  
Hai-Yan Zhao ◽  
Yu-Mei Zhang ◽  
Peng-Qi Li ◽  
...  
Keyword(s):  
Cell Line ◽  
Antiproliferative Activity ◽  
Normal Cell ◽  
Spectroscopic Data ◽  
Human Lung ◽  
Positive Control ◽  
Mucosal Cell ◽  
Human Gastric Adenocarcinoma ◽  
Normal Human

A new series of 4-azasteroidal-17-hydrazone derivatives have been synthesized from androstenedione. Their structures were characterized by analysis and spectroscopic data. The antiproliferative activity of synthesized compounds against three cancer cells (human lung adenocarcinoma, human oesophageal cervical cancer, human gastric adenocarcinoma) and a normal cell line (human gastric mucosal) was investigated. The studies show that the compound bearing a naphthyl group displayed the same antiproliferative activity in vitro against tested cells as cis-platin did (a positive control). Most of the compounds show very weak toxicity towards normal human gastric mucosal cell line.

Cancer Cell Procoagulant Activity

1979 ◽  
Author(s):  
H.R. Gralnick
Keyword(s):  
Overall Survival ◽  
Acute Leukemia ◽  
Acute Lymphocytic Leukemia ◽  
Kinetic Studies ◽  
Lymphocytic Leukemia ◽  
Procoagulant Activity ◽  
Leukemia Cells ◽  
Catabolic Rate ◽  
Human Granulocytes ◽  
Normal Human

Studies of the procoagulant activity (PA) of human acute leukemia cells (ALC) has demonstrated that acute lymphocytic leukemia (ALL) had approximately 25-50% of the PA of normal human granulocytes, while lymphoid leukemias had increased PA. Acute promyelocyte leukemia (APL) had approximately 4-8 times the activity of normal granulocytes while acute myeloblastic leukemia (AML) cells had the same activity as normal. The PA was characterized as tissue factor (TF). Two correlations of the TF activity in ALC is the incidence of the fibrinogen kinetics and intravascular coagulation. He have done fibrinogen survivals on 15 patients with AL. The results of these kinetic studies have revealed that in 5 patients with ALL the T/2 is 2.94 ± .31 days; fraction catabolic rate (FCR) 29.8 ± 4.3%/day were slightly different from the control of T/2 3.69 ± 0.45 days; FCR 22.1 ± 2.5K/day. In 3 patients with AHL, the T/2 was 1.92 ± 0.79 days; FCR 44.2 ± 20.6%/day. In patients with APL, the fibrinogen survival revealed a T/2 of 0.069 ± 0.25 days; FCR 160.9 ± 62.7%/day. The use of anticoagulants in APL markedly decreases death from hemorrhage. In other investigations we have studied the effect of anticoagulation on the spread of peripheral sarcomas in man. Warfarin anticoagulation was used as an adjunct t o amputation of sarcomas. The results of these studies are quite encouraging in that the patients appear to have a longer remission and to have better overall survival.

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