Antihistamine Substances. Tricyclic Analogues of N-(4,4-Diphenyl-3-butene-1-yl)nipecotic Acid and Some Related Compounds

1994 ◽  
Vol 59 (3) ◽  
pp. 667-674 ◽  
Author(s):  
Karel Šindelář ◽  
Alexandra Šilhánková ◽  
Jiří Urban ◽  
Jan Metyš ◽  
Martin Valchář ◽  
...  
Keyword(s):  
Acid Hydrolysis ◽  
Nipecotic Acid ◽  
Amino Esters ◽  
Hydrolysis Of ◽  
Related Compounds

Alkylation of ethyl nipecotate with bromides VII - X gave amino esters Ib - Vb. Alkylation of ethyl piperazine-2-carboxylate with 4-bromo-1,1-diphenyl-1-butene afforded compound Vb. Final product Ia - Va were obtained by acid hydrolysis of corresponding esters Ib - Vb. Some of the compounds showed significant antihistamine and antiulcer activities.

Synthesis and acid hydrolysis of trans-dichlorobis(ethylenediamine)ruthenium(III) and related compounds

1975 ◽  
Vol 14 (10) ◽  
pp. 2575-2577 ◽  
Author(s):  
John A. Broomhead ◽  
Leon. Kane-Maguire ◽  
David. Wilson
Keyword(s):  
Acid Hydrolysis ◽  
Hydrolysis Of ◽  
Related Compounds

Synthesis of 9-(2-Phosphinomethoxyethyl)adenine and Related Compounds

1994 ◽  
Vol 59 (8) ◽  
pp. 1870-1878 ◽  
Author(s):  
Petr Alexander ◽  
Antonín Holý ◽  
Milena Masojídková
Keyword(s):  
Acid Hydrolysis ◽  
Phosphorus Atom ◽  
Amino Group ◽  
Protecting Group ◽  
Hydrolysis Of ◽  
Related Compounds

Alkyl 2-chloroethoxymethyl(diethoxymethyl)phosphinates VII and XIII were prepared by reaction of silyl esters of dialkoxymethylphosphinic acid with 2-chloroethyl chloromethyl ether. Adenine was alkylated with VII and XIII to give [2-(adenin-9-yl)ethoxy]methyl(diethoxymethyl)phosphinates VIII and XIV, bearing the dialkoxymethyl protecting group on the phosphorus atom. Acid hydrolysis of compounds VIII and XIV afforded 9-(2-phosphinoethoxymethyl)adenine (X). Alkyl dialkoxymethylphosphinates V and XI reacted with paraformaldehyde to give hydroxymethylphosphinates XV and XIX which were converted into the synthons XVI, XVII and XVIII capable of introducing a protected hydroxymethylphosphino group on a hydroxy or amino group.

DETERMINATION OF MICRO-AMOUNTS OF 5β-PREGNAN-3α-OL-20-ONE IN URINE USING INFRARED-SPECTROMETRY

1962 ◽  
Vol 41 (2) ◽  
pp. 234-246 ◽  
Author(s):  
H. J. van der Molen
Keyword(s):  
Infrared Spectrum ◽  
Quantitative Determination ◽  
Acid Hydrolysis ◽  
Chromatographic Separation ◽  
Pure Form ◽  
Infrared Spectrometry ◽  
Hydrolysis Of

ABSTRACT A procedure for the quantitative determination of 5β-pregnan-3α-ol-20-one in urine is described. After acid hydrolysis of the pregnanolone-conjugates in urine, the free steroids are extracted with toluene. Pregnanolone is isolated in a pure form as its acetate; after chromatographic separation of the free steroids on alumina, the fraction containing pregnanolone is acetylated and rechromatographed on alumina. Quantitative determination of the isolated pregnanolone-acetate is carried out with the aid of the infrared spectrum recorded by a micro KBr-wafermethod. The reliability of the method under various conditions is discussed under the headings, specificity, accuracy, precision and sensitivity. It is possible to determine 30–40 μg pregnanolone in a 24-hours urine portion with a precision of 25%.

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