Synthesis and antiviral activity of some 2'-C-alkyl derivatives of 9-(2-phosphonomethoxyethyl)adenine

1993 ◽  
Vol 58 (s1) ◽  
pp. 86-90
Author(s):  
Antonín Holý ◽  
Hana Dvořáková ◽  
Ivan Rosenberg
Keyword(s):  
Antiviral Activity ◽  
Alkyl Derivatives ◽  
Derivatives Of

Structure-activity studies on open-chain analogues of nucleosides: Inhibition of S-adenosyl-L-homocysteine hydrolase and antiviral activity 1. Neutral open-chain analogues

1985 ◽  
Vol 50 (1) ◽  
pp. 245-261 ◽  
Author(s):  
Antonín Holý ◽  
Ivan Votruba ◽  
Erik De Clercq
Keyword(s):  
Antiviral Activity ◽  
Alkyl Chain ◽  
Structural Features ◽  
Inhibitory Effects ◽  
Open Chain ◽  
Structure Activity ◽  
Vicinal Diol ◽  
Alkyl Derivatives ◽  
Vesicular Stomatitis ◽  
Derivatives Of

Over 70 alkyl derivatives of purine bases were examined for their inhibitory effects toward rat liver S-adenosyl-L-homocysteine hydrolase and their antiviral activity. The following structural features must be fulfilled by an inhibitor of SAH-hydrolase: an intact adenine moiety, an alkyl chain bound at the 9-position and bearing a vicinal diol at the 2',3'-position, with 2S configuration. An additional substitution at the 3-position lowers or annihilates the inhibitory activity. The enzyme inhibition is reversible. Some of the compounds are substrates of adenosine aminohydrolase. All inhibitors of SAH-hydrolase exhibit antiviral activity, e.g. against vesicular stomatitis virus and vaccinia virus in cell culture, and this antiviral correlates with the inhibition of SAH-hydrolase.

7-O-Alkyl derivatives of daunomycinone

1984 ◽  
Vol 49 (1) ◽  
pp. 313-319 ◽  
Author(s):  
Věra Přikrylová ◽  
Petr Sedmera ◽  
Josef V. Jizba ◽  
Jindřich Vokoun ◽  
Helena Lipavská ◽  
...  
Keyword(s):  
H Nmr ◽  
Toluenesulfonic Acid ◽  
Alkyl Derivatives ◽  
Derivatives Of

Reaction of daunomycinone (I) with alcohols and p-toluenesulfonic acid produces a mixture (~3 : 1) of its (7S)- and (7R)-O-alkyl derivatives II-IX. According to the 1H NMR evidence, the alicyclic ring exists in the 9H8 conformation in (7R)-O-alkyl derivatives, on the contrary to (7S)-epimers and 7-epi-daunomycinone that adopt the 8H9 conformation.

Polarized fluorescense of alkyl derivatives of fluorescein, MitoFluo and C8-Fl, in solutions with liposomes

2020 ◽  
Author(s):  
D.M. Beltukova ◽  
V.P. Belik ◽  
Y.N. Antonenko ◽  
A.A. Bogdanov ◽  
G.A. Korshunova ◽  
...  
Keyword(s):  
Alkyl Derivatives ◽  
Derivatives Of

ChemInform Abstract: SYNTHESIS AND STUDY OF THE ANTIVIRAL ACTIVITY OF THIENYL DERIVATIVES OF ADAMANTANE

1983 ◽  
Vol 14 (13) ◽  
Author(s):  
Z. V. VLASOVA ◽  
R. S. BELEN'KAYA ◽  
A. E. LIPKIN ◽  
I. K. MOISEEV ◽  
M. M. TIMOFEEVA ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Derivatives Of

Synthesis and reactivity of halide, hydride, and alkyl derivatives of (pentamethylcyclopentadienyl)(bisphosphine)iron(II)

1990 ◽  
Vol 9 (1) ◽  
pp. 260-265 ◽  
Author(s):  
Rocco A. Paciello ◽  
Juan M. Manriquez ◽  
John E. Bercaw
Keyword(s):  
Alkyl Derivatives ◽  
Derivatives Of

scholarly journals Synthesis and antiviral activity of novel derivatives of 2'- -C-methylcytidine

2008 ◽  
Vol 52 (1) ◽  
pp. 605-606 ◽  
Author(s):  
J. Fogt ◽  
P. Januszczyk ◽  
G. Framski ◽  
T. Onishi ◽  
K. Izawa ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Derivatives Of

The Alkyl Derivatives of Halogen Phenols and their Bactericidal Action. II. Bromophenols

1933 ◽  
Vol 55 (11) ◽  
pp. 4657-4662 ◽  
Author(s):  
Emil Klarmann ◽  
Louis W. Gates ◽  
Vladimir A. Shternov ◽  
Philip H. Cox
Keyword(s):  
Bactericidal Action ◽  
Alkyl Derivatives ◽  
Derivatives Of

570. Compounds of potential pharmacological interest. Part IV. Aryl and alkyl derivatives of 1-aminoindane

1956 ◽  
pp. 2928 ◽  
Author(s):  
J. A. Barltrop ◽  
R. M. Acheson ◽  
P. G. Philpott ◽  
K. E. MacPhee ◽  
J. S. Hunt
Keyword(s):  
Alkyl Derivatives ◽  
Pharmacological Interest ◽  
Derivatives Of

scholarly journals Hyperbranched Molecular Structures with Potential Antiviral Activity: Derivatives of 5,6-Dihydroxyindole-2-Carboxylic Acid

Molecules ◽  
2006 ◽  
Vol 11 (12) ◽  
pp. 968-977 ◽  
Author(s):  
Mario Sechi ◽  
Fabio Casu ◽  
Ilaria Campesi ◽  
Stefano Fiori ◽  
Alberto Mariani
Keyword(s):  
Carboxylic Acid ◽  
Antiviral Activity ◽  
Molecular Structures ◽  
Derivatives Of

Synthesis and Antiviral Activity of Novel Phosphorylated Derivatives of Didanosine Against Newcastle Disease Virus in Chicken

2016 ◽  
Vol 349 (6) ◽  
pp. 442-455 ◽  
Author(s):  
Karanam Anandan Suresh ◽  
Venkata Subbaiah C. Kadiam ◽  
Thaslim S. K. Basha ◽  
Naga Raju Chamarti ◽  
Suresh M. Kumar ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Derivatives Of
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