Preparation and properties of 2-(dialkylaminomethyl)cyclohexyl and 2-(dialkylaminomethyl)phenyl carbanilates

1990 ◽  
Vol 55 (7) ◽  
pp. 1854-1865 ◽  
Author(s):  
Alena Brádlerová ◽  
Nadežda Prónayová ◽  
Eva Mišíková ◽  
Ján Ďurinda
Keyword(s):  
Acute Toxicity ◽  
Elemental Analysis ◽  
Local Anaesthetic ◽  
Nmr Spectra ◽  
Analysis And Evaluation ◽  
C Nmr

A series of 2-(dialkylaminomethyl)cyclohexyl and 2-(dialkylaminomethyl)phenyl esters of substituted carbanilic acid have been prepared and their identity verified by elemental analysis and evaluation of IR and 13C NMR spectra. The spectral results have been used also for determination of isomerism of the starting 2-dialkylaminomethylcyclohexanols and final carbanilates. Local anaesthetic activity and acute toxicity have been tested with some of the substances.

NMR Determination of the Structure of Peracetylated Icariside B2 from Veratrum Lobelianum BERNH.

1995 ◽  
Vol 60 (8) ◽  
pp. 1380-1385 ◽  
Author(s):  
Václav Suchý ◽  
Miloš Buděšínský ◽  
Karel Ubik ◽  
Daniel Grančai ◽  
Vlasta Földešiová
Keyword(s):  
Detailed Analysis ◽  
Nmr Spectra ◽  
Aerial Part ◽  
C Nmr

rel(1S,4S,5R)-3,3,5-Trimethyl-4-[( 1E)-3-oxo-1-butenyl]-4,5-epoxy-cyclohexyl-O-β-D-glucopyranoside (I) was isolated from the aerial part of Veratrum lobelianum BERNH. The structure was derived mainly from detailed analysis of 1H and 13C NMR spectra of its acetylated derivative II. Compound I has been already reported under the name icariside B2in Epimedium grandiflorum MORR. var. thunbergianum (MIQ.) NAKAI.

Simple NMR Determination of 5α/5β Configuration of 3-Oxosteroids

2001 ◽  
Vol 66 (10) ◽  
pp. 1529-1544 ◽  
Author(s):  
Hana Chodounská ◽  
Miloš Buděšínský ◽  
Romana Šídová ◽  
Miroslav Šíša ◽  
Alexander Kasal ◽  
...  
Keyword(s):  
Nmr Spectra ◽  
Low Frequency ◽  
Simple Method ◽  
H Nmr ◽  
Steroid Skeleton ◽  
C Nmr

A simple method to distinguish the 5α- from the 5β-isomers of 3-oxosteroids based on low-frequency 1H NMR spectra was proposed. Additional 1H and 13C NMR characteristics were derived from the comparison of completely assigned spectra of the 5α- and 5β-isomers. The effect of substitution at different positions of steroid skeleton was evaluated on a series of isomeric 3-oxosteroids, prepared for this purpose.

Synthesis of Nitro-Substituted 4-Oxo-4H-pyrimido[2,1-b]benzothiazole-3-carboxylic Acids and Their Spectral Characteristics

1995 ◽  
Vol 60 (4) ◽  
pp. 583-593 ◽  
Author(s):  
Alexander Bartovič ◽  
Dušan Ilavský ◽  
Ondrej Šimo ◽  
Lubomír Zalibera ◽  
Anna Belicová ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Carboxylic Acids ◽  
Elemental Analysis ◽  
Nmr Spectra ◽  
Spectral Characteristics ◽  
C Nmr

The Gould-Jacobs reaction of all position isomeric 2-aminonitrobenzothiazoles II with diethyl ethoxy- methylenemalonate has been studied. The structure of substitution (IV) and cyclization (VI) products and of the corresponding acids (VIII) was confirmed by elemental analysis, IR, UV, 1H and 13C NMR spectra. Analogous derivatives III, V and VII, derived from the unsubstituted 2-aminobenzothiazole I, were used as standards in interpretation of the spectra. The synthesized derivatives I - VIII were tested for antimicrobial activity.

The determination of the stereochemistry of epoxides located at the 5,6-positions of decalinic systems: An empirical method based on 13C NMR chemical shifts

2002 ◽  
Vol 80 (7) ◽  
pp. 774-778 ◽  
Author(s):  
Raquel M Cravero ◽  
Guillermo R Labadie ◽  
Manuel González Sierra
Keyword(s):  
13C Nmr ◽  
Nmr Spectra ◽  
Chemical Shifts ◽  
Empirical Method ◽  
Nmr Chemical Shifts ◽  
13C Nmr Chemical Shifts ◽  
Empirical Rule ◽  
C Nmr

The 13C NMR spectra of a series of 5,6-epoxides in decalinic systems were studied. The interpretation of the chemical shifts allowed us to formulate an empirical rule to predict the epoxide stereochemistry. A discussion of the scope and limitations of this method and its extension to larger carbon skeletons is also presented.Key words: epoxide stereochemistry, 13C NMR, NMR, decalinic systems, oxiranes.

scholarly journals Nanoparticles of novel organotin(IV) complexes bearing phosphoric triamide ligands

2013 ◽  
Vol 4 ◽  
pp. 94-102 ◽  
Author(s):  
Zahra Shariatinia ◽  
Ebadullah Asadi ◽  
Vahid Tavasolinasab ◽  
Khodayar Gholivand
Keyword(s):  
Fluorescence Spectroscopy ◽  
Elemental Analysis ◽  
Nmr Spectra ◽  
Fluorescence Spectra ◽  
Sem Micrographs ◽  
H Nmr ◽  
Phosphoric Triamide ◽  
C Nmr

Four novel organotin(IV) complexes containing phosphoric triamide ligands were synthesized and characterized by multinuclear (1H, 31P, 13C) NMR, infrared, ultraviolet and fluorescence spectroscopy as well as elemental analysis. The 1H NMR spectra of complexes 1–4 proved that the Sn atoms adopt octahedral configurations. The nanoparticles of the complexes were also prepared by ultrasonication, and their SEM micrographs indicated identical spherical morphologies with particles sizes about 20–25 nm. The fluorescence spectra exhibited blue shifts for the maximum wavelength of emission upon complexation.

scholarly journals Synthesis, Characterization and Antibacterial Activity of Schiff Bases and their Metal Complexes Derived from 4-Acyl-1-phenyl-3-methyl-2-pyrazolin-5-ones and 2-Amino-4(4'-methylphenyl)-thiazole

2010 ◽  
Vol 7 (4) ◽  
pp. 1396-1406 ◽  
Author(s):  
A. S. Thakar ◽  
K. K. Singh ◽  
K. T. Joshi ◽  
A. M. Pancholi ◽  
K. S. Pandya
Keyword(s):  
Antibacterial Activity ◽  
Schiff Bases ◽  
Elemental Analysis ◽  
Mass Spectra ◽  
Nmr Spectra ◽  
Electrical Conductance ◽  
H Nmr ◽  
Infrared Spectral ◽  
Ft Ir ◽  
C Nmr

4-Acyl-1-phenyl-3-methyl-2-pyrazolin-5-ones condensed with 2-amino-4(4'-methylphenyl)-thiazole to form Schiff base. These Schiff bases from complexes of type ML22H2O (M=Mn, Fe, Co, Ni and Cu). Elemental analysis, magnetic susceptibility, electrical conductance, electronic and Infrared spectral data suggested octahedral structure for the complexes. All the compounds were tested for their antibacterial activity. The result indicates that the growth of the tested organism was inhibited by most of the compounds. These Schiff bases are characterized by elemental analysis, mass spectra,1H-NMR spectra,13C NMR spectra and FT IR spectra.

scholarly journals An Experimental Study of the 4hJ(31P–31P) Coupling Constant and the 12C/13C Isotope Effect on 31P in an Iminophosphorane-Substituted Proton Sponge

2002 ◽  
Vol 2002 (1) ◽  
pp. 34-36
Author(s):  
José Elguero ◽  
Alain Fruchier ◽  
María Luisa Jimeno ◽  
Pedro Molina
Keyword(s):  
Experimental Study ◽  
Nmr Spectra ◽  
Chemical Shifts ◽  
Coupling Constants ◽  
Coupling Constant ◽  
Proton Sponge ◽  
Nmr Spectrum ◽  
13C Isotope ◽  
C Nmr

The 13C NMR spectra of the bromide of the protonated iminophosphorane -substituted sponge 7 were recorded at different fields. Together with the use of 13C satellites of the 31P NMR spectrum, these experiments allow determination of a reasonable set of chemical shifts and coupling constants. The most interesting are a 4h JPP = 1.6 Hz, determined directly from the 31P NMR spectrum, which probably involves the hydrogen bond, and a 2Δ31P(13C) isotope shift of 9 ppb.

Synthesis of Some 2-Aminonitroethanes via Silica Gel-Catalyzed Nitro-Mannich Reaction

2006 ◽  
Vol 61 (9) ◽  
pp. 1162-1165 ◽  
Author(s):  
Ali S. Mahasneh
Keyword(s):  
Silica Gel ◽  
Elemental Analysis ◽  
Mannich Reaction ◽  
Nmr Spectra ◽  
One Pot ◽  
H Nmr ◽  
High Yields ◽  
C Nmr

Abstract A direct one pot, three-component nitro-Mannich reaction of a nonenolizable aldehyde, aniline or one of its ring-substituted derivatives and nitromethane was carried out on silica gel surface. The products of the reaction, 2-aminonitroethane, were obtained in high yields. IR, 1H NMR, 13C NMR spectra and elemental analysis confirmed the structures of the products.

Metallkomplexe mit biologisch wichtigen Liganden, XCVI [1] Palladium(II)-, Platin(II)-und Rhodium(I)-Komplexe mit (Phenyl)C-H···Metall-Wechselwirkung von Diphenylmethylen- glycinestern und von 2-Phenyloxazolinonen / Metal Complexes of Biologically Important Ligands, XCVI [1] Palladium(II), Platinum(II) and Rhodium(I) Complexes with (Phenyl)-C-H ··· Metal Interaction of Diphenylmethylene Glycine Esters and from 2-Phenyloxazolones

1997 ◽  
Vol 52 (10) ◽  
pp. 1199-1202 ◽  
Author(s):  
Bernhard Schreiner ◽  
Markus Prem ◽  
Werner Bauer ◽  
Kurt Polborn ◽  
Wolfgang Beck
Keyword(s):  
Metal Complexes ◽  
Nmr Spectra ◽  
Structural Determination ◽  
X Ray ◽  
Metal Interaction ◽  
Close Proximity ◽  
C Nmr

The reactions of Na2PdCl4, [(nBu3P)PtCl2]2, [(nBu3P)PdCl2]2 and [(C8H14)2RhCl]2/CO with diphenylmethylene glycine esters (L1) or 2-phenyl-4-R-oxazolones (L2) afford the complexes (nBu3P)(Cl)2Pt(L1), (OC)2(Cl)Rh(L1), Cl2Pd(L1)2 and (nBu3P)(Cl)2M(L2) (M = Pd, Pt), respectively. The X-ray structural determination of Cl2Pd(L1)2 and the 1H and 13C NMR spectra show a close proximity of the ortho phenyl-H-atom to the metal; the complexes are precursors for ortho metallation.

The Preparation of Some Mono-and Bis(thiolate)-2-butyne Complexes of Tungsten(II) of the Types [WI(SR)(CO)(dppm )(η2-MeC2Me)] {dppm = Ph2P(CH2)PPh2; R = Et, But, Ph or CH2Ph} and [W (SR)2(CO)(dppm)(η2-MeC2Me)]

1994 ◽  
Vol 49 (11) ◽  
pp. 1544-1548 ◽  
Author(s):  
Paul K. Baker ◽  
Kevin R. Flower
Keyword(s):  
Nmr Spectroscopy ◽  
Elemental Analysis ◽  
Good Yield ◽  
Nmr Spectra ◽  
Room Temperature ◽  
H Nmr ◽  
Thiolate Complexes ◽  
C Nmr

Equimolar quantities of [WI(CO)(NCMe)(dppm)(η2-MeC2Me)][BF4] {dppm = Ph2P(CH2)PPh2) and NaSR (R = Et. But ,Ph or CH2Ph) react in CH2Cl2 at room temperature to give the neutral thiolate complexes [WI(SR)(CO)(dppm)(η2-MeC2Me)] (1 → 4) in good yield. The complex [WI(CO)(NCMe)(dppm)(η2-MeC2Me)][BF4] also reacts with two equiv­alents of NaSR (R = Et. But, Ph or CH2Ph) in CH2Cl2 at room temperature to afford the bis(thiolate) complexes [W(SR)2(CO)(dppm)(η2-MeC2Me)] (5 → 8), in good yield. Com­plexes 1→8 have been characterized by elemental analysis (C, H and N), IR and 1H NMR spectroscopy. 13C NMR spectra of selected complexes indicate that the 2-butyne ligand is donating four electrons to the metal in both [WI(SR)(CO)(dppm)(η2-MeC2Me)] and [W(SR)2(CO)(dppm)(η2-MeC2Me)] type complexes.

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