Potential cerebral stimulants: Esters of 2-dimethylaminoethanol with some lipophilic carboxylic acids

1990 ◽  
Vol 55 (5) ◽  
pp. 1278-1289 ◽  
Author(s):  
Miroslav Protiva ◽  
Vladimír Valenta ◽  
Zdeňka Kopicová ◽  
Juraj Lukáč ◽  
Jiří Holubek ◽  
...  
Keyword(s):  
Succinic Acid ◽  
Carboxylic Acids ◽  
Acid Chlorides ◽  
Pharmacological Testing

2-Dimethylaminoethyl esters of 2,2-dimethylpropanoic, heptanoic, octanoic, decanoic, hexadecanoic, cyclopentylacetic, cycloheptylacetic, 2-cyclopentylhexanoic, (4-chlorophenoxy)fumaric, and 2-(4-chlorophenoxy)succinic acid were prepared by reactions of the acid chlorides with 2-dimethylaminoethanol and were transformed to crystalline salts for pharmacological testing. The ester IX (hydrogen fumarate V⁄FB-14 005) was found to antagonize significantly halothan amnesia in rats and the ester X (hydrogen fumarate V⁄FB-14004) proved to be an anticholinergic spasmolytic agent.

Facile Reduction of Carboxylic Acids, Esters, Acid Chlorides, Amides and Nitriles to Alcohols or Amines Using NaBH4/BF3×Et2O.

ChemInform ◽  
2004 ◽  
Vol 35 (34) ◽  
Author(s):  
Su-Dong Cho ◽  
Yong-Dae Park ◽  
Jeum-Jong Kim ◽  
J. R. Falck ◽  
Yong-Jin Yoon
Keyword(s):  
Carboxylic Acids ◽  
Acid Chlorides

Simultaneous Gas Chromatographic Determination of Carboxylic Acids in Soft Drinks and Jams

1985 ◽  
Vol 68 (5) ◽  
pp. 902-905
Author(s):  
Taizo Tsuda ◽  
Hiroshi Nakanishi ◽  
Takashi Morita ◽  
Junko Takebayashi
Keyword(s):  
Benzoic Acid ◽  
Succinic Acid ◽  
Tartaric Acid ◽  
Carboxylic Acids ◽  
Fumaric Acid ◽  
Malic Acid ◽  
Sorbic Acid ◽  
Chromatographic Determination ◽  
Dehydroacetic Acid

Abstract A method was developed for simultaneous gas chromatographic determination of sorbic acid, dehydroacetic acid, and benzoic acid used as preservatives, and succinic acid, fumaric acid, malic acid, and tartaric acid used as acidulants in soft drinks and jams. A sample was dissolved in NH4OH-NH4CI pH 9 buffer solution, and an aliquot of the solution was passed through a QAE-Sephadex A 25 column. The column was washed with water, and the carboxylic acids were eluted with 0.1N HC1. Sorbic acid, dehydroacetic acid, and benzoic acid were extracted with ethyl ether-petroleum ether (1 + 1), and determined on a 5% DEGS + 1% H3PO4 column. Succinic acid, fumaric acid, malic acid, and tartaric acid in the lower layer were derivatized with N,0- bis(trimethylsilyl)acetamide and trimethylchlorosilane, and determined on a 3% SE-30 column. Recoveries from soft drink and jam samples fortified with 0.1% each of 7 carboxylic acids ranged from 92.4 to 102.6% for preservatives, and from 88.1 to 103.2% for acidulants.

Reaction of acid chlorides with amides of dialkylphosphoric and carboxylic acids

1972 ◽  
Vol 21 (1) ◽  
pp. 132-134
Author(s):  
P. I. Alimov ◽  
L. N. Levkova ◽  
L. A. Antokhina ◽  
I. V. Cheplanova
Keyword(s):  
Carboxylic Acids ◽  
Acid Chlorides

ChemInform Abstract: A New Synthesis of β,γ-Alkenyl Carboxylic Acids from α,β-Alkenyl Carboxylic Acid Chlorides and α,β-Alkenyl Aldehydes with One-Carbon Elongation.

ChemInform ◽  
2010 ◽  
Vol 33 (12) ◽  
pp. no-no
Author(s):  
Tsuyoshi Satoh ◽  
Akira Nakamura ◽  
Atsuko Iriuchijima ◽  
Yasumasa Hayashi ◽  
Ko-ichi Kubota
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Acid Chlorides ◽  
New Synthesis
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