Effect of electron correlation on SN2 activation barriers. Fourth-order MBPT calculations

1988 ◽  
Vol 53 (10) ◽  
pp. 2239-2249 ◽  
Author(s):  
Ivan Černušák ◽  
Miroslav Urban
Keyword(s):  
Gas Phase ◽  
Barrier Height ◽  
Fourth Order ◽  
Electron Correlation ◽  
Activation Barriers ◽  
Vital Importance ◽  
Nucleophilic Displacement ◽  
Displacement Reactions ◽  
Individual Contributions

The activation barriers for a series of model gas-phase nucleophilic displacement reactions have been calculated at the MBPT(4)/DZ + P + D level. Electron correlation significantly reduces the barrier height, in most cases by about 50%. The role of individual contributions up to the fourth order MBPT is analyzed in detail showing the vital importance of single and triple excitations.

The gas phase reactivity of the dimethylchloronium ion with alkylbenzenes

1981 ◽  
Vol 59 (15) ◽  
pp. 2412-2416 ◽  
Author(s):  
John A. Stone ◽  
Margaret S. Lin ◽  
Jeffrey Varah
Keyword(s):  
High Pressure ◽  
Gas Phase ◽  
Mass Spectrometer ◽  
Aromatic Hydrocarbons ◽  
Relative Rate ◽  
Ion Source ◽  
Nucleophilic Displacement ◽  
Rate Of Reaction ◽  
Displacement Reactions ◽  
Bonded Complexes

The reactivity of the dimethylchloronium ion with a series of aromatic hydrocarbons has been studied in a high pressure mass spectrometer ion source using the technique of reactant ion monitoring. Benzene is unreactive but all others, from toluene to mesitylene, react by CH3+ transfer to yield σ-bonded complexes. The relative rate of reaction increases with increasing exothermicity in line with current theories of nucleophilic displacement reactions.

Gas-phase nucleophilic displacement reactions

1995 ◽  
Vol 30 (12) ◽  
pp. 1653-1662 ◽  
Author(s):  
William N. Olmstead ◽  
John I. Brauman
Keyword(s):  
Gas Phase ◽  
Nucleophilic Displacement ◽  
Displacement Reactions

scholarly journals An Assessment of Computational Methods for Calculating Accurate Structures and Energies of Bio-Relevant Polysulfur/Selenium-Containing Compounds

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3323 ◽  
Author(s):  
Sahar Nikoo ◽  
Paul Meister ◽  
John Hayward ◽  
James Gauld
Keyword(s):  
Inorganic Chemistry ◽  
Bond Length ◽  
Gas Phase ◽  
Electron Correlation ◽  
Negative Charge ◽  
Basis Set ◽  
Proton Affinities ◽  
Selenium Compounds ◽  
Gas Phase Basicities

The heavier chalcogens sulfur and selenium are important in organic and inorganic chemistry, and the role of such chalcogens in biological systems has recently gained more attention. Sulfur and, to a lesser extent selenium, are involved in diverse reactions from redox signaling to antioxidant activity and are considered essential nutrients. We investigated the ability of the DFT functionals (B3LYP, B3PW91, ωB97XD, M06-2X, and M08-HX) relative to electron correlation methods MP2 and QCISD to produce reliable and accurate structures as well as thermochemical data for sulfur/selenium-containing systems. Bond lengths, proton affinities (PA), gas phase basicities (GPB), chalcogen–chalcogen bond dissociation enthalpies (BDE), and the hydrogen affinities (HA) of thiyl/selenyl radicals were evaluated for a range of small polysulfur/selenium compounds and cysteine per/polysulfide. The S–S bond length was found to be the most sensitive to basis set choice, while the geometry of selenium-containing compounds was less sensitive to basis set. In mixed chalcogens species of sulfur and selenium, the location of the sulfur atom affects the S–Se bond length as it can hold more negative charge. PA, GPB, BDE, and HA of selenium systems were all lower, indicating more acidity and more stability of radicals. Extending the sulfur chain in cysteine results in a decrease of BDE and HA, but these plateau at a certain point (199 kJ mol−1 and 295 kJ mol−1), and PA and GPB are also decreased relative to the thiol, indicating that the polysulfur species exist as thiolates in a biological system. In general, it was found that ωB97XD/6-311G(2d,p) gave the most reasonable structures and thermochemistry relative to benchmark calculations. However, nuances in performance are observed and discussed.

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