Preparation and some reactions of bis(2',3'-O-carbonyl-6-azauridine) 5',5''-carbonate

1988 ◽  
Vol 53 (7) ◽  
pp. 1568-1573 ◽  
Author(s):  
Pavel Drašar ◽  
Jiří Beránek
Keyword(s):  
Title Compound ◽  
Sodium Methoxide ◽  
Cyclic Carbonate

Reaction of 6-azauridine (I) with phosgene and hexamethylphosphoramide afforded the title compound II. Both its 2',3'-cyclic carbonate groups were selectively deblocked with methanolic sodium methoxide under preservation of the internucleoside carbonate bridge. The carbonate II was also converted into the 5',5''-carbonyloxybis(2,2'-anhydro) derivative III by heating with imidazole in N,N-dimethylformamide. Several analogues of II were prepared by reaction of 1,1'-carbonyldiimidazole with the corresponding nucleosides in N,N- dimethylformamide.

scholarly journals Isomerization of 1-exo-4,5,67,8,8-Heptachloro-2,3-endo-epoxy-3a,4,7,7a-methanoindane with Base

1971 ◽  
Vol 49 (21) ◽  
pp. 3569-3571 ◽  
Author(s):  
W. P. Cochrane ◽  
M. A. Forbes
Keyword(s):  
Reductive Dechlorination ◽  
Title Compound ◽  
Sodium Methoxide ◽  
Structure Elucidation ◽  
Secondary Alcohol ◽  
Major Product ◽  
Excess Sodium

Treatment of the title compound, 2, with excess sodium methoxide produced an unsaturated secondary alcohol, 3. Structure elucidation was achieved by MnO2 oxidation followed by CrCl2 reductive dechlorination to give as the major product 2-oxa-4,5,6,7,8,8-hexachloro-3a,4,7,7a-tetrahydro-4,7-methanoindane.

C-Nucleosides and related compounds. VIII. Synthesis of 5-(4′β-hydroxymethyl-2′β,3′α-dihydroxycyclopent-1′β-yl)-6-azauracil

1976 ◽  
Vol 54 (18) ◽  
pp. 2925-2934 ◽  
Author(s):  
G. Just ◽  
R. Ouellet
Keyword(s):  
Double Bond ◽  
Title Compound ◽  
Sodium Methoxide ◽  
Alder Reaction ◽  
Oxidative Cleavage ◽  
Diels Alder ◽  
Keto Ester ◽  
Diels Alder Reaction ◽  
Related Compounds

Starting from the Diels–Alder reaction of trans-β-bromoacrylic acid with cyclopentadiene, a synthesis of the substituted bicycloheptene 8 is described. The stereochemistry of the substituents is clearly defined. Oxidative cleavage of the double bond in the compound 8c afforded an acid keto ester 10 that was treated with thiosemicarbazide. Treatment of the resulting thiosemicarbazone 11 with sodium methoxide gave a 3-thioxo-1,2,4-triazine-5-one compound that was converted into the title compound.

Synthetic transformations of dimethyl perfluoro-4-methyl-2-pentenedioate

1982 ◽  
Vol 47 (12) ◽  
pp. 3418-3423 ◽  
Author(s):  
Jiří Svoboda ◽  
Oldřich Paleta ◽  
Václav Dědek
Keyword(s):  
Sodium Borohydride ◽  
Title Compound ◽  
Sodium Methoxide ◽  
Fluorine Atom ◽  
Synthetic Transformations

Reaction of the title compound I with methanolic sodium methoxide proceeded with decarboxylation and substitution of the vinylic fluorine atom, the resulting product being methyl 2,4,5,5,5-pentafluoro-3-methoxy-2-pentenoate (II). Compound I reacted with chlorine to give dimethyl 2,3-dichloro-2,3,4-trifluoro-4-trifluoromethylpentanedioate (III) which was selectively hydrolyzed to potassium 1-methyl 2,3-dichloro-2,3,4-trifluoro-4-trifluoromethylpentanedioate (IV). This ester salt was transformed in two steps into methyl 2,3-dichloro-4-fluoroformylhexafluoropentanoate (VIII). Pyrolysis of IV afforded methyl 2-chlorohexafluoro-3-pentanoate (V). Reduction of the diester III with sodium borohydride led to 3-chloro-2,3,4-trifluoro-2-hydroxymethyl-4-trifluoromethyloxolane (IX) and 2,3-dichloro-2,3,4-trifluoro-4-trifluoromethyl-1,5-pentane diol (X).

scholarly journals Crystal structure of 1,2,3,4-di-O-methylene-α-D-galactopyranose

2015 ◽  
Vol 71 (12) ◽  
pp. o961-o962
Author(s):  
Ioannis Tiritiris ◽  
Stefan Tussetschläger ◽  
Willi Kantlehner
Keyword(s):  
Crystal Structure ◽  
Hydrogen Bonds ◽  
Title Compound ◽  
Sodium Methoxide ◽  
Three Dimensional ◽  
Boat Conformation ◽  
Pyranose Ring ◽  
Compound C ◽  
Dimensional Network ◽  
Twist Boat

The title compound, C8H12O6, was synthesized by deacetylation of 6-acetyl-1,2,3,4-di-O-methylene-α-D-galactose with sodium methoxide. The central part of the molecule consists of a six-membered C5O pyranose ring with a twist-boat conformation. Both fused dioxolane rings adopt an envelope conformation with C and O atoms as the flap. In the crystal, O—H...O and C—H...O hydrogen bonds are present between adjacent molecules, generating a three-dimensional network.

Highly stereoselective H–D exchange of diastereotopic protons in 4′,1″-dimethyl-1,2,3,4-dibenzylcyclohepta-1,3-diene-6-one

1976 ◽  
Vol 54 (23) ◽  
pp. 3809-3811 ◽  
Author(s):  
Robert R. Fraser ◽  
Philippe J. Champagne
Keyword(s):  
Carbonyl Group ◽  
Title Compound ◽  
Sodium Methoxide ◽  
Rate Ratio

The rates of base-catalyzed H–D exchange of the diastereotopic methylene protons adjacent to the carbonyl group in the title compound have been measured in methanol-O-d. Sodium methoxide as catalyst produced a rate ratio of 73:1. Reasons for the large increase in stereoselectivity over that encountered in the exchange of 4-tert-butylcyclohexanone are proposed.

Immunocytochemical localization of desmin and vimentin in chick embryonic myocardial cells

1990 ◽  
Vol 48 (3) ◽  
pp. 448-449
Author(s):  
Yukiko Sugi
Keyword(s):  
Sodium Methoxide ◽  
Intermediate Filament Protein ◽  
Chick Embryos ◽  
Immunocytochemical Localization ◽  
Myocardial Cells ◽  
Immunofluorescence Study ◽  
Immunofluorescent Localization ◽  
Rabbit Igg ◽  
Semithin Sections ◽  
Filament Protein

In cultured skeletal muscle cells of chick, one intermediate filament protein, vimentin, is primarily formed and then synthesis of desmin follows. Coexistence of vimentin and desmin has been immunocytochemically confirmed in chick embryonic skeletal musclecells. Immunofluorescent localization of vimentin and desmin has been described in developing myocardial cells of hamster. However, initial localization of desmin and vimentin in early embryonic heart has not been reported in detail. By quick-freeze deep-etch method a loose network of intermediate filaments was revealed to exist surrounding myofibrils. In this report, immunocytochemical localization of desmin and vimentin is visualized in early stages of chick embryonic my ocardium.Chick embryos, Hamburger-Hamilton (H-H) stage 8 to hatch, and 1 day old postnatal chicks were used in this study. For immunofluorescence study, each embryo was fixed with 4% paraformaldehyde and embedded in Epon 812. De-epoxinized with sodium methoxide, semithin sections were stained with primary antibodies (rabbit anti-desmin antibody and anti-vimentin antibody)and secondary antibody (RITC conjugated goat-anti rabbit IgG).

Crystal structure of 12H+-2,4-benzo-1,5-dioxa-8,12,16-triaza-cyclooctadec-2-ene-7,17-dione picrate

2002 ◽  
Vol 217 (1) ◽  
Author(s):  
G. Hundal ◽  
S. Kumar ◽  
M. S. Hundal ◽  
H. Singh
Keyword(s):  
Crystal Structure ◽  
Title Compound ◽  
Compound C

AbstractThe title compound [C

A neutron diffraction study of hydrogen bonding in the deuterium (hydrogen) L-arginine phosphate monohydrate

1997 ◽  
Vol 212 (3) ◽  
Author(s):  
Z. Cheng ◽  
Y. Cheng ◽  
L. Guo ◽  
D. Xu
Keyword(s):  
Crystal Structure ◽  
Hydrogen Bonding ◽  
Neutron Diffraction ◽  
Diffraction Study ◽  
Title Compound ◽  
Neutron Diffraction Study ◽  
Chemical Formula

AbstractThe crystal structure of the title compound D(H)LAP with chemical formula (D

Experimental and Theoretical (ab initio and DFT) Analysis of UV-Vis Spectra, Thermodynamic Functions and Non-linear Optical Properties of 2-Chloro-3,4-Dimethoxybenzaldehyde

2015 ◽  
Vol 8 (2) ◽  
pp. 2122-2134
Author(s):  
Sarvendra Kumar ◽  
Rajesh Kumar ◽  
Jayant Teotia ◽  
M. K. Yadav
Keyword(s):  
Thermodynamic Functions ◽  
Title Compound ◽  
Density Functional ◽  
Structural Characteristics ◽  
Basis Sets ◽  
Ultraviolet Absorption Spectrum ◽  
Non Linear ◽  
Different Temperatures ◽  
Linear Optical Properties ◽  
Linear Optical

In the present work, UV- Visible spectra of 2-Chloro-3,4-Dimethoxybenzaldehyde (2,3,4-CDMB) compound  have been carried out experimentally and theoretically. The ultraviolet absorption spectrum of title compound in three solvents (Acetone, Diethyl Ether, CCl4) of different polarity were examined in the range of 200–500 nm. The structure of the molecule was optimized and the structural characteristics were determined by HF and DFT (B3LYP) methods with 6-31+G(d,p) and 6-311++G(d,p) as basis sets. The excitation energy, wavelength corresponds to absorption maxima () and oscillator strength (f) are calculated by Time-Dependent Density Functional Theory (TD-DFT) using B3LYP/6-31+G(d,p) and B3LYP/6-311++G(d,p) as basis sets. The electric dipole moment (μ), polarizability (α) and the first hyperpolarizability (β ) have been computed to evaluate the non-linear optical (NLO) response of the investigated compound by HF and DFT (B3LYP) with already mentioned basis sets. Thermodynamic functions of the title compound at different temperatures were also calculated.

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