Study of the azo-hydrazone tautomeric equilibrium by electronic spectroscopy and quantum chemistry. I. Electronic spectra

1988 ◽  
Vol 53 (2) ◽  
pp. 213-226 ◽  
Author(s):  
Miloš Nepraš ◽  
Miloš Titz ◽  
Miroslav Nečas ◽  
Stanislav Luňák ◽  
Radim Hrdina ◽  
...  
Keyword(s):  
Electronic Spectra ◽  
Low Temperatures ◽  
Electronic Spectroscopy ◽  
Tautomeric Equilibrium ◽  
Proton Donor ◽  
Ring Fusion ◽  
And Topology ◽  
Amino Derivatives ◽  
Spectral Patterns ◽  
Derivatives Of

The azo-hydrazone tautomeric equilibrium was studied for p-hydroxy and p-amino derivatives of some arylazo compounds. Substantial differences were observed between the spectral patterns in hydrocarbon and alcoholic solutions at normal and low temperatures; these are due to shifts in the azo-hydrazone tautomeric equilibrium, which depends on the nature of the proton donor para substituent, size and topology of the system (aromatic ring fusion patterns), solvent and temperature. The spectral patterns suggest that the proton transfer from the para substituent takes place after dimerization of the molecule.

Study of the azo-hydrazone tautomeric equilibrium by electronic spectroscopy and quantum chemistry. II. HMO calculations

1988 ◽  
Vol 53 (2) ◽  
pp. 227-242 ◽  
Author(s):  
Miloš Titz ◽  
Miloš Nepraš ◽  
Miroslav Nečas ◽  
Radim Hrdina ◽  
Stanislav Luňák ◽  
...  
Keyword(s):  
Experimental Data ◽  
Quantum Chemistry ◽  
Quantum Chemical ◽  
Chemical Method ◽  
Electronic Spectroscopy ◽  
Tautomeric Equilibrium ◽  
Quantum Chemical Method ◽  
Fused Ring ◽  
Amino Derivatives ◽  
Derivatives Of

Experimental data obtained in Part I of this work for p-hydroxy and p-amino derivatives of four arylazo compounds with different fused ring systems were correlated with some indices calculated by the simple HMO quantum chemical method in relation to the π-electron structure of the azo and hydrazone tautomers of the compounds studied. Mental fragmentation and the related stability of the systems expressed by Julg’s aromaticity indices of the hydrocarbon fragments appeared to be basically different for the two tautomers.

Electronic spectra and structure of several amino derivatives of anthraquinone in different states of aggregation

1980 ◽  
Vol 32 (4) ◽  
pp. 344-348 ◽  
Author(s):  
G. N. Rodionova ◽  
I. V. Krutovskaya ◽  
A. N. Rodionov ◽  
Yu. G. Tuchin ◽  
V. V. Karpov
Keyword(s):  
Electronic Spectra ◽  
Amino Derivatives ◽  
Derivatives Of

Synthesis, Docking Studies into CDK-2 and Anticancer Activity of New Derivatives Based Pyrimidine Scaffold and Their Derived Glycosides

2019 ◽  
Vol 19 (13) ◽  
pp. 1093-1110 ◽  
Author(s):  
Adel A.H. Abdel Rahman ◽  
Ibrahim F. Nassar ◽  
Amira K.F. Shaban ◽  
Dina S. EL-Kady ◽  
Hanem M. Awad ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Human Liver ◽  
Docking Studies ◽  
Cyclin Dependent Kinase ◽  
Binding Interaction ◽  
Enzyme Active Site ◽  
Human Liver Cancer ◽  
Amino Derivatives ◽  
Activity Behavior ◽  
Derivatives Of

Background & Objective:New diaryl-substituted pyrimidinedione compounds, their thioxo derivatives as well as their bicyclic thiazole compounds were synthesized and characterized.Methods:The glycosylamino derivatives of the synthesized disubstituted derivatives of the pyrimidine scaffold were also prepared via reaction of the N3-amino derivatives with a number of monosaccharides followed by acetylation.Results:The anticancer activity of the synthesized compounds was studied against human liver cancer (HepG2) and RPE-1cell lines. Compounds 2a, 2b, 3a and 12 showed potent activities with IC50 results comparable to that of doxorubicin.Conclusion:Docking investigations into Cyclin-dependent kinase 2 (CDK-2) enzyme, a potential target for cancer medication, were also reported showing the possible binding interaction into the enzyme active site to support their activity behavior.

Thermal cyclocondensations of 3-N(4- and 5-benzimidazolyl and benztriazolyl)amino derivatives of 2-propenoic acid

1987 ◽  
Vol 52 (12) ◽  
pp. 2918-2925 ◽  
Author(s):  
Viktor Milata ◽  
Dušan Ilavský
Keyword(s):  
Uv Spectra ◽  
Propenoic Acid ◽  
Amino Derivatives ◽  
Derivatives Of ◽  
C Nmr ◽  
Ir And Uv Spectra

The cyclization of 3-N(4- and 5-benzimidazolyl and benztriazolyl)amino-2-cyano- and 2-ethoxycarbonyl-2-propenoate esters Ia, b-IVa, b under the conditions of the Gould-Jacobs reaction leads to angularly ring-fused substituted imidazo or triazolo[4,5-f] (V, VI) and [4,5-h] (VII, VIII) quinolines, respectively. The esters Vb-VIIIb have been transformed into the corresponding chloroderivatives Vc-VIIIc. 3-N(5-Benzimidazolyl and 5-benztriazolyl)amino-2-cyano-2-propenenitriles are cyclized in the presence of aluminium(III) chloride to give the aminoquinolines Vd, VId. The structure of the products has been characterized by their 1H, 13C NMR, IR, and UV spectra.

ChemInform Abstract: SYNTHESIS AND ANTITUMOR ACTIVITY OF 6-OXO-7-AMINO DERIVATIVES OF 5H-PYRIDO(2,3B)- AND 5H-PYRIMIDO(4,5B)(1,4)THIAZINES

1985 ◽  
Vol 16 (15) ◽  
Author(s):  
N. I. TRAVEN' ◽  
YU. A. ERSHOVA ◽  
A. S. SOKOLOVA ◽  
V. A. CHERNOV ◽  
T. S. SAFONOVA
Keyword(s):  
Antitumor Activity ◽  
Amino Derivatives ◽  
Derivatives Of

Synthesis of 4-Amino Derivatives of 5-Oxoproline

2007 ◽  
Vol 2007 (25) ◽  
pp. 4257-4266 ◽  
Author(s):  
Victor P. Krasnov ◽  
Alexey Yu. Vigorov ◽  
Irina A. Nizova ◽  
Tatyana V. Matveeva ◽  
Alexander N. Grishakov ◽  
...  
Keyword(s):  
Amino Derivatives ◽  
Derivatives Of

Preparation of new amino derivatives of the lactone tanachin and their antimicrobial activity

1996 ◽  
Vol 32 (1) ◽  
pp. 19-22
Author(s):  
M. B. Izbosarov ◽  
B. Kh. Abduazimov ◽  
M. É. Tuichieva ◽  
M. N. Yusupov ◽  
V. M. Malikov ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Amino Derivatives ◽  
Derivatives Of

scholarly journals Structure-activity studies of 20-deoxo-20-amino derivatives of tylosin-related macrolides.

1989 ◽  
Vol 42 (11) ◽  
pp. 1673-1683 ◽  
Author(s):  
H. A. KIRST ◽  
K. E. WILLARD ◽  
M. DEBONO ◽  
J. E. TOTH ◽  
B. A. TRUEDELL ◽  
...  
Keyword(s):  
Structure Activity ◽  
Amino Derivatives ◽  
Derivatives Of
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