Analysis of hydroformylation products of higher n-alkenes by capillary gas chromatography

1985 ◽  
Vol 50 (8) ◽  
pp. 1808-1818 ◽  
Author(s):  
Ján Krupčík ◽  
Dušan Repka
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Reaction Mechanism ◽  
Stationary Phase ◽  
Capillary Gas Chromatography ◽  
Stationary Phases ◽  
Capillary Columns ◽  
Gas Chromatography Mass Spectrometry ◽  
Chromatography Mass Spectrometry

A mixture of alcohols obtained by hydroformylation of C10-C13 n-alkenes was analyzed by capillary gas chromatography using Carbowax 20M stationary phase, and acetates prepared from the alcohols were analyzed on capillary columns using Carbowax 20M and Apiezon L stationary phases. The capillary gas chromatography and gas chromatography-mass spectrometry treatment gave evidence that all of the 24 alcohols that could form by the hydroformylation reaction mechanism were present.

Screening and quantification of hypnotic sedatives in serum by capillary gas chromatography with a nitrogen-phosphorus detector, and confirmation by capillary gas chromatography-mass spectrometry.

1986 ◽  
Vol 32 (2) ◽  
pp. 325-328 ◽  
Author(s):  
V A Soo ◽  
R J Bergert ◽  
D G Deutsch
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Capillary Gas Chromatography ◽  
Gas Chromatography Mass Spectrometry ◽  
Detector Response ◽  
Capillary Gc ◽  
Chromatography Mass Spectrometry ◽  
Nitrogen Phosphorus Detector ◽  
Sedative Drugs ◽  
Nitrogen Phosphorus

Abstract We describe a quantitative screen for hypnotic-sedative drugs in which we use capillary gas chromatography with a nitrogen-phosphorus detector (GC/NPD) as the primary method and capillary gas chromatography-mass spectrometry (GC-MS) for confirmation. GC retention times of the acid-extracted underivatized drugs were stable (CVs less than 1%), and the detector response varied linearly over a 20-fold concentration range with a mean correlation coefficient for 11 drugs of 0.989. The limits of detection were satisfactory (0.5 mg/L in a 0.5-mL serum sample and 1-microL injection volume), as were precision (average CV 5.2% within day, 6.4% between day). The complementary use of capillary GC-MS not only unambiguously confirms presumptive peaks identified by GC, but also prevents reports of false positives and identifies compounds not included in the quantitative GC screen that may be listed in the GC-MS library.

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