Structural analogues of 5,6-tetramethyleneuracil ribosides - Inhibitors of enzymes participating in nucleic acid synthesis

1985 ◽  
Vol 50 (1) ◽  
pp. 280-285 ◽  
Author(s):  
Marcin Dramiński ◽  
Elżbieta Frass ◽  
Janusz Greger ◽  
Krystyna Fabianowska-Majewska
Keyword(s):  
Nucleic Acid ◽  
Dna Synthesis ◽  
Acid Synthesis ◽  
Nucleic Acid Synthesis ◽  
Structural Analogues ◽  
Derivatives Of

1-N and 3-N ribosyl, allyl and (RS)-2',3'-dihydroxypropyl derivatives of 5,6-tetramethyleneuracil were prepared. Some of described compounds are inhibitors of enzymes involving in regulation of DNA synthesis.

NUCLEIC ACID SYNTHESIS BY A LYSOGENIC STRAIN OF ESCHERICHIA COLI INFECTED WITH ANrII MUTANT OF COLIPHAGE T2

1959 ◽  
Vol 5 (1) ◽  
pp. 17-24 ◽  
Author(s):  
J. F. Whitfield ◽  
K. M. Baird
Keyword(s):  
Escherichia Coli ◽  
Nucleic Acid ◽  
Dna Synthesis ◽  
Ultraviolet Irradiation ◽  
Acid Synthesis ◽  
Host Cells ◽  
Nucleic Acid Synthesis ◽  
Desoxyribonucleic Acid ◽  
E Coli ◽  
Lysogenic Culture

Mutants of phage T2, of the group called rII mutants, are known to lack the parent phage's ability to form plaques on strains of Escherichia coli lysogenic for phage λ That they are capable of initiating desoxyribonucleic acid synthesis in the infected lysogenic host cells but are incapable of maintaining it has been shown by the present study using T2r7and -E. coli C112 (λs). In contrast with the superficially similar behavior shown by some other phages (e.g. λv1h), ultraviolet irradiation and consequent induction of the lysogenic culture do not release the prophage-linked inhibition of T2r7DNA synthesis. Net ribose-nucleic acid synthesis is stopped in all cultures on infection with T2r7.

scholarly journals Role of Folic Acid and Energy Intake in Nucleic Acid Synthesis

1959 ◽  
Vol 234 (3) ◽  
pp. 625-627
Author(s):  
Ranjan Mehta ◽  
David A. Vaughan ◽  
Shreepad R. Wagle ◽  
Kendall D. Barbee ◽  
S.P. Mistry ◽  
...  
Keyword(s):  
Folic Acid ◽  
Nucleic Acid ◽  
Energy Intake ◽  
Acid Synthesis ◽  
Nucleic Acid Synthesis
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