Preparation of pregnane derivatives from bile acids

1984 ◽  
Vol 49 (7) ◽  
pp. 1617-1621 ◽  
Author(s):  
Růžena Míčková
Keyword(s):  
Bile Acids ◽  
Derivatives Of ◽  
Cholanic Acid

The paper describes decarboxylation of derivatives of 3α,12α-dihydroxy-5β-cholanic acid to 24-norchol-22-ene, and conversion of this key intermediate to pregnane derivatives.

scholarly journals Studies on the antibacterial properties of the bile acids and some compounds derived from cholanic acid

1947 ◽  
Vol 134 (877) ◽  
pp. 523-537 ◽  
Keyword(s):  
Molecular Structure ◽  
Staphylococcus Aureus ◽  
Surface Tension ◽  
Bile Acids ◽  
Antibacterial Properties ◽  
Simple Relationship ◽  
The Relationship ◽  
Positive Complex ◽  
Cholanic Acid ◽  
Limiting Dilution

In this work the bile acids and certain of their derivatives have been studied with regard to their bacteriostatic power and relative activities in removing the Gram-positive complex from yeast. No correlation between these properties was obtained. A simple relationship was apparent, however, between the bacteriostatic activities of the compounds and their ability to depress the surface tension of the metabolism medium. The limiting dilution at which the 'active' bile acids were bacteriostatic for Staphylococcus aureus corresponded to a depression of the surface tension of the medium by approximately 4∙5 dynes. The relationship between bacteriostatic power and surface activity was only valid for this particular series of compounds of closely related molecular structure.

scholarly journals Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors

Molecules ◽  
2018 ◽  
Vol 23 (3) ◽  
pp. 679 ◽  
Author(s):  
Oksana Salomatina ◽  
Irina Popadyuk ◽  
Alexandra Zakharenko ◽  
Olga Zakharova ◽  
Dmitriy Fadeev ◽  
...  
Keyword(s):  
Bile Acids ◽  
Derivatives Of

scholarly journals Microwave-assisted green synthesis of bile acid derivatives and evaluation of glucocorticoid receptor binding

2020 ◽  
Author(s):  
Bojana R. Vasiljević ◽  
Edward T. Petri ◽  
Sofija S. Bekić ◽  
Andjelka S. Ćelić ◽  
Ljubica M. Grbović ◽  
...  
Keyword(s):  
Bile Acid ◽  
Microwave Irradiation ◽  
Glucocorticoid Receptor ◽  
Ligand Binding ◽  
Green Synthesis ◽  
Bile Acids ◽  
Receptor Binding ◽  
Microwave Assisted ◽  
Bile Acid Derivatives ◽  
Cholanic Acid

Green synthesis of bile acids derivatives and 5β-cholanic acid was achieved under microwave irradiation, and the binding affinity for the ligand binding domain of the glucocorticoid receptor was measured.

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