Growth inhibition of Escherichia coli B by nucleoside analogs

1983 ◽  
Vol 48 (7) ◽  
pp. 2088-2095 ◽  
Author(s):  
Markyta Bártová ◽  
Miloš Ryba ◽  
Zdena Jedličková ◽  
Ladislav Novotný ◽  
Hubert Hřebabecký ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antibacterial Activity ◽  
Growth Inhibition ◽  
Nucleoside Analogs ◽  
Pyrimidine Nucleosides ◽  
High Antibacterial Activity ◽  
Inhibition Of Growth ◽  
Escherichia Coli B ◽  
Low Activity ◽  
Very High

The inhibition of growth of Escherichia coli B by series of 6-azaanalogs of pyrimidine nucleosides, their precursors, and analogs of cancerostatic agents 5-fluorouracil and arabinosylcytosine is reported. A very high antibacterial activity is observed with most of the 5-fluorouracil nucleosides where a cleavage (30%) to 5-fluorouracil is observed at the most active compounds (5-fluorouridine, 5-fluoro-2'-deoxyuridine). Arabinosylcytosine and its derivatives express very low activity.

scholarly journals Phytochemical, HPLC Analysis and Antibacterial Activity of Crude Methanolic and Aqueous Extracts for Some Medicinal Plant Flowers.

2016 ◽  
Vol 2 (2) ◽  
Author(s):  
Erian, N. S.; H. B. Hamed, A. Y. El-Khateeb & M. Farid
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Salicylic Acid ◽  
Growth Inhibition ◽  
Hplc Analysis ◽  
Polyphenolic Compounds ◽  
Aqueous Extracts ◽  
Methanolic Extracts ◽  
Activity Complex

Methanolic and aqueous extracts of C. cardunculus, A. millefolium, C. officinalis, and M. chamomilla flowers were Phytochemical, Identification of polyphenols and flavonoids by HPLC, and also investigated for their antibacterial activity, Escherichia coli, Staphylococcus aureus and Bacillus subtillis. The phytochemical was observed that crude methanolic and aqueous extracts of investigated flowers the highest content from activity complex. HPLC analysis identified eighteen polyphenolic compounds as authentic samples namely: Gallic acid, pyrogallol, 4-amino benzoic, protocatechuic, cataehein, chlorogenic, catechol, e.picatechen, caffien, p.oh.benzoic, caffeic, vanillic, ferulic, ellagic, benzoic acid, salicylic acid, coumarin and cinnamic acid. While, flavonoid compounds its eleven compounds as authentic samples namely: narengin, rutin, hisperdin, romarinic, quereitrin, quereetrin, narenginin, kampferol, luteolin, hispertin, and 7-Hydoxyflavon. The methanolic extracts of C. officinalis and M. chamomilla flowers produced the highest growth inhibition (43.88 and 42.11%) for against B. subtillis at 6 mg/ml, While, the aqueous extracts of C. officinalis and M. chamomilla flowers produced the highest growth inhibition (29.99 and 29.22 %) for against Bacillus subtillis at 6 mg/ml. Moreover, the C. officinalis and C. cardunculus flowers extract produced the highest growth inhibition for methanolic and aqueous extracts of against Escherichia coli at 6 mg/ml.  

scholarly journals Properties of Binuclear Rhodium(II) Complexes and Their Antibacterial Activity

1996 ◽  
Vol 3 (4) ◽  
pp. 185-195 ◽  
Author(s):  
Florian P. Pruchnik ◽  
Małgorzata Bień ◽  
Tadeusz Lachowicz
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Nmr Spectroscopy ◽  
Antibacterial Agents ◽  
Structure And Properties ◽  
E Coli ◽  
Nitrogen Ligands ◽  
Low Activity

Binuclear rhodium(II) complexes [Rh2Cl2(μ-OOCR)2(N-N)2], [Rh2(μ-OOCR)2(N-N)2(H2O)2](RCOO)2 and [Rh2Cl2(μ-OOCCH3)(terpy)2](H3O)Cl2.9H2O (R = H, Me, Bun,ph, PhCHOH; N-N = 2,2′-bipyridine (bpy), 1,10-phenanthroline (phen), 2,9-dimethyl-1,10-phenanthroline (dmp) and 6,7-dimethyl-2,3- di(2-pyridyl)quinoxaline (dmpq); terpy 2,2′:6′,2′′-terpyridine) have been synthesized and their structure and properties have been studied by electronic, IR and H1 NMR spectroscopy. Antibacterial activity of these complexes against Staphylococcus aureus and Escherichia coli has been investigated. The most active antibacterial agents against S. aureus were [Rh2(OOCPh)2(phen)2(H2O)2]2+, [Rh2(OOCPh)2(dmpq)2(H2O)2]2+, [Rh2(OOCBu)2(phen)2(H2O)2]2+ and [Rh2-(OOCBu)2(bpy)2(H2O)2]2+ which were considerably more active than the appropriate nitrogen ligands. The complexes show rather low activity against E. coli.

scholarly journals 5-Bromo-1-(4-chlorobenzyl)-1H-indole-2-carboxamides as new potent antibacterial agents

2018 ◽  
Vol 24 (6) ◽  
pp. 327-332 ◽  
Author(s):  
Yogesh D. Mane ◽  
Smita S. Patil ◽  
Dhanraj O. Biradar ◽  
Bhimrao C. Khade
Keyword(s):  
Escherichia Coli ◽  
Antibacterial Activity ◽  
Antibacterial Agents ◽  
Inhibitory Concentration ◽  
Antibacterial Activities ◽  
Gram Negative Bacteria ◽  
Internal Standards ◽  
Gram Negative ◽  
E Coli ◽  
High Antibacterial Activity

Abstract Ten 5-bromoindole-2-carboxamides were synthesized, characterized and evaluated for antibacterial activity against pathogenic Gram-negative bacteria Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Salmonella Typhi using gentamicin and ciprofloxacin as internal standards. Compounds 7a–c, 7g and 7h exhibit high antibacterial activity with a minimum inhibitory concentration (MIC) of 0.35–1.25 μg/mL. Compounds 7a–c exhibit antibacterial activities that are higher than those of the standards against E. coli and P. aeruginosa.

scholarly journals Binuclear Rhodium(II) Complexes With Selective Antibacterial Activity

1997 ◽  
Vol 4 (2) ◽  
pp. 81-88 ◽  
Author(s):  
Małgorzata Bień ◽  
Tadeusz M. Lachowicz ◽  
Agnieszka Rybka ◽  
Florian P. Pruchnik ◽  
Lilianna Trynda
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Nmr Spectroscopy ◽  
Antibacterial Agents ◽  
Structure And Properties ◽  
E Coli ◽  
Nitrogen Ligands ◽  
And Staphylococcus Aureus ◽  
Low Activity

Binuclear rhodium(II) complexes [Rh2Cl2(μ-OOCR)2(N-N)2] {R = H, Me; N-N = 2,2'-bipyridine (bpy), 1,10-phenanthroline (phen)} and [Rh2(μ-OOCR)2(N-N)2(H2O)2](RCOO)2 (R = Me, Et;) have been synthesized and their structure and properties have been studied by electronic, IR and H1 NMR spectroscopy. Antibacterial activity of these complexes against Escherichia coli and Staphylococcus aureus has been investigated. The most active antibacterial agents against E. coli were [Rh2Cl2(μ-OOCR)2(N-N)2] and [Rh2(μ-OOCR)2(N-N)2(H2O)2](RCOO)2 {R = H and Me} which were considerably more active than the appropriate nitrogen ligands. The complexes show low activity against S. aureus. The activity of the complexes [Rh2(OOCR)2(N-N)2(H2O)2](OOCR)2 against E. coli decreases in the series: R=H≅CH3>C2H5>C3H7≅C4H9. The reverse order was found in the case of S. aureus.

scholarly journals Investigation of Nanoparticle Metallic Core Antibacterial Activity: Gold and Silver Nanoparticles against Escherichia coli and Staphylococcus aureus

2021 ◽  
Vol 22 (4) ◽  
pp. 1905
Author(s):  
Jimmy Gouyau ◽  
Raphaël E. Duval ◽  
Ariane Boudier ◽  
Emmanuel Lamouroux
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Metallic Nanoparticles ◽  
Catalytic Reduction ◽  
Gold And Silver Nanoparticles ◽  
High Antibacterial Activity ◽  
Vis Spectroscopy ◽  
Broth Microdilution Method

Multidrug-resistant (MDR) bacteria constitute a global health issue. Over the past ten years, interest in nanoparticles, particularly metallic ones, has grown as potential antibacterial candidates. However, as there is no consensus about the procedure to characterize the metallic nanoparticles (MNPs; i.e., metallic aggregates) and evaluate their antibacterial activity, it is impossible to conclude about their real effectiveness as a new antibacterial agent. To give part of the answer to this question, 12 nm gold and silver nanoparticles have been prepared by a chemical approach. After their characterization by transmission electronic microscopy (TEM), Dynamic Light Scattering (DLS), and UltraViolet-visible (UV-vis) spectroscopy, their surface accessibility was tested through the catalytic reduction of the 4-nitrophenol, and their stability in bacterial culture medium was studied. Finally, the antibacterial activities of 12 nm gold and silver nanoparticles facing Staphylococcus aureus and Escherichia coli have been evaluated using the broth microdilution method. The results show that gold nanoparticles have a weak antibacterial activity (i.e., slight inhibition of bacterial growth) against the two bacteria tested. In contrast, silver nanoparticles have no activity on S. aureus but demonstrate a high antibacterial activity against Escherichia coli, with a minimum inhibitory concentration of 128 µmol/L. This high antibacterial activity is also maintained against two MDR-E. coli strains.

scholarly journals Synthesis of novel pyridine-connected piperidine and 2H-thiopyran derivatives and their larvicidal, nematicidal, and antimicrobial activities

2019 ◽  
Vol 62 (4) ◽  
Author(s):  
Idhayadhulla Akbar ◽  
Anis Ahamed ◽  
Ibrahim A. Arif ◽  
Radhakrishnan Surendra Kumar ◽  
Keerthana Selva raj ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antibacterial Activity ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Klebsiella Pneumoniae ◽  
Antimicrobial Activities ◽  
High Antibacterial Activity ◽  
Microsporum Audouinii ◽  
Ld50 Value ◽  
High Antifungal Activity

A series of novelpyridine-connected piperidine derivatives (2a-g) and pyridine-connected 2H-thiopyran derivatives (4a-g) were synthesized and screened for larvicidal, nematicidal, and antimicrobial activities. Compound 4e exhibited larvicidal activity against second instar larvae with an LD50 value of 0.8μg/mL. In addition, 4e exhibited high nematicidal activity, with an LD50 value of 3.2μg/mL.Compounds 2e (MIC: 4 μg/mL) and 2d (MIC: 4 μg/mL) exhibited high antibacterial activity against Klebsiella pneumoniae and Escherichia coli, respectively. Compounds 4b (MIC: 0.25 μg/mL) and 4f (MIC: 2 μg/mL) showed high antifungal activity against Candida albicans and Microsporum audouinii, respectively. Therefore, it can be suggested that compounds 2e, 2d, 4e, 4b, and 4f may be useful as lead molecules for the development of new classes ofdrugs with larvicidal,nematicidal,and antimicrobial activities.

scholarly journals Towards a new treatment against polymicrobial infections: high antibacterial activity of lemon IntegroPectin against Pseudomonas aeruginosa and Escherichia coli

2020 ◽  
Author(s):  
Alessandro Presentato ◽  
Antonino Scurria ◽  
Lorenzo Albanese ◽  
Pasquale Picone ◽  
Mario Pagliaro ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Industrial Development ◽  
Antimicrobial Treatment ◽  
Hydrodynamic Cavitation ◽  
E Coli ◽  
High Antibacterial Activity ◽  
New Treatment ◽  
Polymicrobial Infections

AbstractLemon IntegroPectin obtained via hydrodynamic cavitation of waste lemon peel in water only shows high antibacterial activity against two Gram-negative bacteria, Pseudomonas aeruginosa and Escherichia coli. The antibacterial effect against the ubiquitous pathogen P. aeruginosa was evaluated in terms of the minimal bactericidal (MBC) and minimal inhibitory concentration (MIC). Preliminary insight on the antibacterial mechanism of IntegroPectin originates from investigating its inhibitory activity against E. coli. Given the non-cytotoxic nature of citrus IntegroPectin and the ease of its reproducible production in large amounts, the route is open to the industrial development of a new antimicrobial treatment against polymicrobial infections unlikely to develop drug resistance.

scholarly journals Biochemical Studies on Bio Extracts as Antioxidant and Antibacterial Activity

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Farid, M, Hanaa, F. M. Ali, Gehan, F. A. Massoud, Sherein S.
Keyword(s):  
Escherichia Coli ◽  
Antibacterial Activity ◽  
Growth Inhibition ◽  
Methanolic Extract ◽  
Reducing Power ◽  
Tilia Cordata ◽  
Phytochemical Screening ◽  
Total Polyphenols ◽  
Antioxidants Activity ◽  
Biochemical Studies

Biochemical Evaluated of some bio extracts as follows: Chemical composition and Phytochemical screening were determined in Tilia Cordata and Vitex Agnus leaves. The total polyphenols and flavonoids contents of Tilia Cordata leaves have the highest of total polyphenols and flavonoids contents, which were 126.00mgGAE/g and 15.88mgQE/g, followed by Vitex Agnus leaves, which were 119.77mgGAE/g and 13.41mgQE/g, respectively. Methanolic and aqueous extracts of plants leaves were antioxidant activity by used (FRAP, LPO, DPPH and ABTS) The methanolic extract of Tilia Cordata and Vitex Agnus  leaves, have the highest of reducing power which were 1.649 and 1.018 at the concentrations of 80mg/ml, respectively. Also, by used (LPO, DPPH and ABTS), were the highest antioxidants activity for methanolic extract respectively. Moreover, the methanolic extract of Tilia Cordata leaves produced the highest growth inhibition (18 and 17mm) for against Escherichia coli and Bacillus subtillis at 4mg/ml, respectively. While, The methanolic extract of Vitex Agnus produced the medium percentage of growth inhibition (10.5, 9.75 and 10mm) for against Escherichia coli, St.coccus aureus and Bacillus subtillis at 4mg/ml, respectively. And compared with antibiotic. This study concluded that Tilia Cordata and Vitex Agnus  leaves extract has an antioxidant and antibacterial activity.

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