Some 1-β-D-ribofuranosyl-5-phenylcytosines and -5-(2-chlorophenyl)-2-thiocytosine

1982 ◽  
Vol 47 (8) ◽  
pp. 2145-2149 ◽  
Author(s):  
Zdeněk Buděšínský ◽  
František Šmejkal ◽  
Miloš Buděšínský
Keyword(s):  
Herpes Simplex ◽  
Catalytic Reduction ◽  
Inhibitory Effect ◽  
Amino Derivative ◽  
Nitro Derivative ◽  
Trimethylsilyl Derivatives ◽  
Simplex Virus

5-Phenylcytidine (XI), 5-(4-nitrophenyl)cytidine (XII) and 5-(2-chlorophenyl)-2-thiocytidine (XIII) were prepared from corresponding trimethylsilyl derivatives V-VII. Nitro derivative XII was converted to amino derivative XIV by catalytic reduction. Cytidines XI-XIV and the starting cytosines I-IV do not display any in vitro inhibitory effect against the influenza virus AWS, virus NDV, vaccinia, herpes simplex and WEE, or in vivo effect on mice infected with the herpes simplex virus type 2 (HSV-2) either.

scholarly journals ent-Epiafzelechin-(4α→8)-epiafzelechin extracted from Cassia javanica inhibits herpes simplex virus type 2 replication

2006 ◽  
Vol 55 (2) ◽  
pp. 201-206 ◽  
Author(s):  
Hua-Yew Cheng ◽  
Chien-Min Yang ◽  
Ta-Chen Lin ◽  
Den-En Shieh ◽  
Chun-Ching Lin
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Inhibitory Effect ◽  
Human Populations ◽  
Dependent Manner ◽  
Virus Attachment ◽  
Life Threatening ◽  
Simplex Virus

Herpes simplex virus (HSV) is a ubiquitous organism that causes infections in human populations throughout the world. It causes a variety of diseases ranging in severity from mild to life-threatening. In this study, ent-epiafzelechin-(4α→8)-epiafzelechin (EEE) extracted from the fresh leaves of Cassia javanica L. agnes de Wit (Leguminosae) was investigated for its in vitro anti-HSV-2 activity using XTT and plaque reduction assays. Results showed that EEE inhibited HSV-2 replication in a dose-dependent manner. The IC50 value was 83·8±10·9 and 166·8±12·9 μM for XTT and plaque reduction assays, respectively. EEE did not affect the viability and the proliferation of cells at antiviral concentrations. Mechanistic studies demonstrated that EEE prevented HSV-2 from penetrating the cell and also interfered with HSV-2 replication at the late stage of its life cycle. It also disturbed virus attachment but the inhibitory effect was minor. In summary, the conclusion of this study was that EEE exhibits various modes of action in suppressing HSV-2 multiplication.

scholarly journals Antiviral Effects of ABMA against Herpes Simplex Virus Type 2 In Vitro and In Vivo

Viruses ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 119 ◽  
Author(s):  
Wenwen Dai ◽  
Yu Wu ◽  
Jinpeng Bi ◽  
Shuai Wang ◽  
Fang Li ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Antiviral Effects ◽  
Simplex Virus

scholarly journals Activity of compounds containing echinochrome A against herpes simplex virus type 2 in vitro and in vivo

2019 ◽  
pp. 56-64 ◽  
Author(s):  
N. V. Krylova ◽  
I. A. Leneva ◽  
S. A. Fedoreev ◽  
L. K. Ebralidze ◽  
N. P. Mishchenko ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Antioxidant Properties ◽  
Echinochrome A ◽  
Simplex Virus

The aim of the work was to study the activity of echinochrome A, a naphthoquinoid pigment from sea urchins, and its antioxidant composition against herpes simplex virus type 2 (HSV-2) in vitro and in vivo.Materials and methods. Strain HSV-2 (G ATCC VR-734) was grown in Vero cells. The cytotoxic and anti-HSV-2 activity of the compounds was assessed in vitro by the cell viability and by cytopathic effect inhibition of virus using MTT test. The efficacy of compounds in mice model of vaginitis caused by HSV-2 was determined by the average lifetime, body weight and viral load changes.Results and discussion. The antioxidant composition (echinochrome A, ascorbic acid and α-tocopherol (5:5:1)), showed a higher antiviral efficacy than echinochrome A alone. Oral administration of the antioxidant composition protected 90% of the infected mice against death and reduced vaginal viral loads. The antiviral activity of echinochrome A and the antioxidant composition is probably due to the virus-inhibiting activity of the compounds and their antioxidant properties.Conclusion. The results obtained allow considering the tested compounds as promising agents with antiviral properties.

scholarly journals Suppression of human papillomavirus gene expression in vitro and in vivo by herpes simplex virus type 2 infection

Virology ◽  
2003 ◽  
Vol 314 (1) ◽  
pp. 147-160 ◽  
Author(s):  
L Fang ◽  
M.G Ward ◽  
P.A Welsh ◽  
L.R Budgeon ◽  
E.B Neely ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Papillomavirus ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus

Efficacy of ASP2151, a helicase–primase inhibitor, against thymidine kinase-deficient herpes simplex virus type 2 infection in vitro and in vivo

2012 ◽  
Vol 93 (2) ◽  
pp. 301-304 ◽  
Author(s):  
Takehiro Himaki ◽  
Yumi Masui ◽  
Koji Chono ◽  
Tohru Daikoku ◽  
Masaya Takemoto ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus
Sign in / Sign up

Export Citation Format

Share Document