Synthesis and conformational investigation of β-turn forming tetra- and hexapeptides

1982 ◽  
Vol 47 (7) ◽  
pp. 1884-1892
Author(s):  
A. N. Abdel Rahman ◽  
S. Abdel Rahman
Keyword(s):  
Energy Transfer ◽  
Phase Method ◽  
Conformational Study ◽  
Poly Ethylene Glycol ◽  
High Solubility ◽  
Liquid Phase Method ◽  
Conformational Investigation ◽  
Transfer Method ◽  
Poly Ethylene ◽  
Good Agreement

Tetra- and hexapeptides containing Pro-Gly or Gly-Pro or Aib-Pro in their sequences were synthesized using the liquid-phase method. The high solubility of the poly(ethylene glycol) bound peptides in water and in organic solvents enables the application of the singlet-singlet energy transfer method for conformational investigation of these peptides. The conformational study in solid state by IR and in solution by CD were carried out in parallel to the energy transfer method. The qualitative results generated by IR and CD were found to be in good agreement with the quantitative end-to-end distances given by the energy transfer method.

New, easily removable poly(ethylene glycol) supports for the liquid-phase method of peptide synthesis

1980 ◽  
Vol 45 (26) ◽  
pp. 5364-5370 ◽  
Author(s):  
V. N. Rajasekharan Pillai ◽  
Manfred Mutter ◽  
Ernst Bayer ◽  
Ian Gatfield
Keyword(s):  
Liquid Phase ◽  
Ethylene Glycol ◽  
Peptide Synthesis ◽  
Phase Method ◽  
Poly Ethylene Glycol ◽  
Liquid Phase Method ◽  
Poly Ethylene

Synthesis of elastin-like peptides using the liquid phase method

1987 ◽  
Vol 52 (5) ◽  
pp. 1352-1355 ◽  
Author(s):  
M. E. Younes ◽  
S. Abdel Rahman ◽  
A. Hattaba
Keyword(s):  
Liquid Phase ◽  
Monomethyl Ether ◽  
Phase Method ◽  
Alternative Possibility ◽  
Poly Ethylene Glycol ◽  
Ethylene Glycol Monomethyl Ether ◽  
Glycol Monomethyl Ether ◽  
Conformational Studies ◽  
Liquid Phase Method ◽  
Poly Ethylene

Elastin-like peptides were synthesized by the liquid-phase method using poly(ethylene glycol) monomethyl ether (PEGM) (m.w. 5 000) as solubilizing support which provides an alternative possibility for conformational studies and spectroscopic measurements in solution. The following sequences were synthesized: Boc-Ala-Pro-Gly-Val-APEGM, Boc-Ala-Pro-Gly-Val-Gly-Val-APEGM, Boc-Ala-Pro-Gly-Val-Ala-Pro-Gly-Val-Gly-Val-APEGM, Boc-Ala-Pro-Gly-Val-Gly-Val-Ala-Pro-Gly-Val-Gly-Val-APEGM.

Rapid Assembly of Oligosaccharides by Using a Hydrophobic Tag-Assisted Liquid-Phase Method

Synlett ◽  
2020 ◽  
Vol 31 (12) ◽  
pp. 1163-1166
Author(s):  
Fengting Chu ◽  
Quhao Wei ◽  
Ping Wang ◽  
Dan Lu ◽  
Siyao Wang ◽  
...  
Keyword(s):  
Liquid Phase ◽  
Polar Solvent ◽  
Nonpolar Solvent ◽  
Phase Method ◽  
Synthetic Route ◽  
High Solubility ◽  
Environmental Friendly ◽  
Liquid Phase Method ◽  
Work Up

A 3,5-didocosyloxybenzyl alcohol tag that was introduced at the anomeric position of the carbohydrate acceptor was applied in the assembly of a pentasaccharide. The intrinsic high solubility in nonpolar solvent and precipitation properties in polar solvent are crucial features of this tag. Thus, rapid and simple precipitation-centrifugation can be conducted throughout the synthetic route at each step to ease work-up and purification processes, and reduce the amount of solvent required. This method provides an efficient, environmental-friendly, and economical approach to synthesize complex oligosaccharides.

Sign in / Sign up

Export Citation Format

Share Document