Use of phenylacetyl group for protection of the lysine Nε-amino group in synthesis of peptides

1981 ◽  
Vol 46 (8) ◽  
pp. 1983-1989 ◽  
Author(s):  
František Brtník ◽  
Tomislav Barth ◽  
Karel Jošt
Keyword(s):  
Peptide Synthesis ◽  
Peptide Chain ◽  
Amino Group ◽  
Protecting Group ◽  
Lysine Vasopressin

Nε-Phenylacetyllysine was used in the synthesis of deamino-lysine-vasopressin. The phenylacetyl protecting group is stable under conditions of peptide synthesis and can be removed by action of penicillin amidohydrolase (E.C.3.5.1.11) without damaging the built peptide chain.

Fmoc Solid Phase Peptide Synthesis

1999 ◽  
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Peptide Chain ◽  
Standard Approach ◽  
Side Chain ◽  
Complex Structures ◽  
Protein Conjugation ◽  
Chemoselective Ligation ◽  
Routine Production

In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The basic problems outstanding at the time of publication of this earlier work have now been, for the most part, solved. As a result, innovators in the field have focussed their efforts to develop methodologies and chemistry for the synthesis of more complex structures. The focus of this new volume is much broader, and covers not only the essential procedures for the production of linear peptides but also more advanced techniques for preparing cyclic, side-chain modified, phospho- and glycopeptides. Many other methods also deserving attention have been included: convergent peptide synthesis; peptide-protein conjugation; chemoselective ligation; and chemoselective purification. The difficult preparation of cysteine and methionine-containing peptides is also covered, as well as methods for overcoming aggregation during peptide chain assembly and a survey of available automated instrumentation.

o-Nitrobenzoyl group as a new amino protecting group for peptide synthesis and the synthesis of some anthranilyl peptides

Tetrahedron ◽  
1973 ◽  
Vol 29 (4) ◽  
pp. 625-628 ◽  
Author(s):  
A.K. Koul ◽  
J.M. Bachhawat ◽  
B. Prashad ◽  
N.S. Ramegowda ◽  
A.K. Mathur ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Protecting Group

The 2-chloro-3-indenylmethyloxycarbonyl and benz[f]inden-3-ylmethyloxycarbonyl base-sensitive amino-protecting group. Application to an inverse Merrifield approach to peptide synthesis

1990 ◽  
Vol 55 (1) ◽  
pp. 251-259 ◽  
Author(s):  
Louis A. Carpino ◽  
Beri J. Cohen ◽  
Yao Zhong Lin ◽  
Kenton E. Stephens ◽  
Salvatore A. Triolo
Keyword(s):  
Peptide Synthesis ◽  
Protecting Group

ChemInform Abstract: New Strategies for an Efficient Removal of the 9-Fluorenylmethoxycarbonyl (Fmoc) Protecting Group in the Peptide Synthesis.

ChemInform ◽  
2010 ◽  
Vol 31 (16) ◽  
pp. no-no
Author(s):  
Antonella Leggio ◽  
Angelo Liguori ◽  
Anna Napoli ◽  
Carlo Siciliano ◽  
Giovanni Sindona
Keyword(s):  
Peptide Synthesis ◽  
Protecting Group ◽  
Efficient Removal ◽  
Fmoc Protecting Group ◽  
New Strategies
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