Identification of impurities in benzyl butyl phthalate by gas-liquid chromatography and mass spectrometry

1979 ◽  
Vol 44 (7) ◽  
pp. 2202-2210 ◽  
Author(s):  
Jan Novrocík ◽  
Marta Novosadová
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Routine Analysis ◽  
Gaseous Ammonia ◽  
Side Reactions ◽  
Gas Liquid Chromatography ◽  
Optimum Conditions ◽  
Advantages And Disadvantages ◽  
Benzyl Butyl Phthalate ◽  
Butyl Phthalate

The impurities present in benzyl butyl phthalate of Monsanto, Belgium, and in benzyl butyl phthalate prepared by a modified procedure employing gaseous ammonia instead of triethylamine were identified by GLC-MS. Columns appropriate for the GLC analysis of this plasticizer were selected and their advantages and disadvantages discussed, and the optimum conditions for complete, rapid routine analysis of benzyl butyl phthalate were established. The side reactions proceeding during the preparation of benzyl butyl phthalate are discussed based on the identification of the impurities present.

Concentrations of non-glucose polyols in serum and cerebrospinal fluid from apparently healthy adults and children.

1984 ◽  
Vol 30 (2) ◽  
pp. 188-191 ◽  
Author(s):  
S Yoshioka ◽  
S Saitoh ◽  
S Seki ◽  
K Seki
Keyword(s):  
Mass Spectrometry ◽  
Cerebrospinal Fluid ◽  
Liquid Chromatography ◽  
Healthy Subjects ◽  
Metabolic Diseases ◽  
Gas Liquid Chromatography ◽  
Liquid Chromatography Mass Spectrometry ◽  
Adults And Children ◽  
Healthy Persons ◽  
Apparently Healthy

Abstract Six non-glucose polyols--mannose, fructose, 1-deoxyglucose, mannitol, glucitol, and inositol--were identified and evaluated in human serum and cerebrospinal fluid by gas-liquid chromatography and by gas-liquid chromatography/mass spectrometry. Concentrations of fructose, mannose, and inositol in the serum of healthy persons or children without metabolic diseases varied with age, as already reported for 1-deoxyglucose. Fructose, inositol, and glucitol concentrations in cerebrospinal fluid significantly exceeded those in serum. The method described here for determining polyols and for evaluating polyol patterns in serum, as well as the resulting data on children and healthy subjects, should be useful in investigations of the clinical and physiological significance of polyols.

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