Determination of thermodynamic functions by means of infrared spectroscopy. The accuracy in -ΔH determination; Formation of complexes phenol-pyridine and its homologues

Václav Šára; Jaromír Moravec; Milan Horák

doi:10.1135/cccc19790148

Determination of thermodynamic functions by means of infrared spectroscopy. The accuracy in -ΔH determination; Formation of complexes phenol-pyridine and its homologues

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19790148 ◽

1979 ◽

Vol 44 (1) ◽

pp. 148-156 ◽

Cited By ~ 2

Author(s):

Václav Šára ◽

Jaromír Moravec ◽

Milan Horák

Keyword(s):

Infrared Spectroscopy ◽

Thermodynamic Functions ◽

Ionization Constants ◽

Experimental Conditions ◽

Pyridine Bases ◽

Methyl Derivatives ◽

Pyridinic Nitrogen ◽

Influence Of Substituents ◽

Formation Of Complexes

Values of thermodynamic functions -ΔH, -ΔG, and -ΔS of the complex formation between molecules of pyridine (and its methyl derivatives) and phenol in CCl4 solutions were determined using infrared spectroscopy. After optimalizing experimental conditions the error in -ΔH determination does not exceed 0.2%; this accuracy is sufficiently high to investigate the influence of substituents on the pyridinic nitrogen basicity. The values of -ΔH determined in this way correlate linearly with values of ionization constants of pyridine bases.

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Determination of thermodynamic functions by means of infrared spectroscopy. II. Axial and equatorial hydrogen bonds

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19721990 ◽

1972 ◽

Vol 37 (6) ◽

pp. 1990-1992 ◽

Cited By ~ 1

Author(s):

M. Horák ◽

V. Šára ◽

J. Moravec

Keyword(s):

Infrared Spectroscopy ◽

Hydrogen Bonds ◽

Thermodynamic Functions

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Determination of thermodynamic functions by means of infrared spectroscopy. Complex formation in phenol-aliphatic sulfide and phenol-aliphatic sulfoxide systems

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19692390 ◽

1969 ◽

Vol 34 (8) ◽

pp. 2390-2397 ◽

Cited By ~ 2

Author(s):

V. Šára ◽

J. Moravec ◽

V. Horák ◽

M. Horák

Keyword(s):

Infrared Spectroscopy ◽

Complex Formation ◽

Thermodynamic Functions

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Determination of ionization constants of N-imidazole derivatives, aromatase inhibitors, using capillary electrophoresis and influence of substituents on pKa shifts

Journal of Chromatography A ◽

10.1016/j.chroma.2004.02.053 ◽

2004 ◽

Vol 1035 (1) ◽

pp. 131-136 ◽

Cited By ~ 19

Author(s):

C. Foulon ◽

C. Danel ◽

C. Vaccher ◽

S. Yous ◽

J.-P. Bonte ◽

...

Keyword(s):

Capillary Electrophoresis ◽

Aromatase Inhibitors ◽

Ionization Constants ◽

Imidazole Derivatives ◽

Pka Shifts ◽

Influence Of Substituents

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Antithrombin-mediated Inhibition of Factor Vlla-Tissue Factor Complex by the Synthetic Pentasaccharide Representing the Heparin Binding Site to Antithrombin

Thrombosis and Haemostasis ◽

10.1055/s-0038-1650512 ◽

1996 ◽

Vol 76 (01) ◽

pp. 005-008 ◽

Cited By ~ 22

Author(s):

Jean Claude Lormeau ◽

Jean Pascal Herault ◽

Jean Marc Herbert

Keyword(s):

Binding Site ◽

Tissue Factor ◽

Residual Activity ◽

Coagulation Factors ◽

Heparin Binding ◽

Experimental Conditions ◽

First Order ◽

Heparin Binding Site ◽

Coagulant Activity

SummaryWe examined the effect of the synthetic pentasaccharide representing the minimal binding site of heparin to antithrombin on the antithrombin-mediated inactivation of factor Vila bound to tissue factor. This effect was compared to the effect of unfractionated heparin. Using purified recombinant human coagulation factors and either a clotting or an amidolytic assay for the determination of the residual activity of factor Vila, we showed that the pentasaccharide was an efficient antithrombin-dependent inhibitor of the coagulant activity of tissue factor-factor Vila complex. In our experimental conditions, assuming a mean MW of 14,000 for heparin, the molar pseudo-first order rate constants for ATIII-mediated FVIIa inhibition by ATIII-binding heparin and by the synthetic pentasaccharide were found to be similar with respective values of 104,000 ± 10,500 min-1 and 112,000 ± 12,000 min-1 (mean ± s.e.m., n = 3)

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