Condensation of 2-furyl alkyl ketones and 2-furyl aryl ketones with substances having an active methylene group

1977 ◽  
Vol 42 (2) ◽  
pp. 726-730 ◽  
Author(s):  
M. Černayová ◽  
J. Kováč ◽  
J. Surá
Keyword(s):  
Aryl Ketones ◽  
Active Methylene ◽  
Methylene Group

Synthesis and Transformations of Ethyl 3-Formyl-1H-indole-2-carboxylate. Preparation of Aplysinopsin and β-Carboline Thiohydantoin Analogues

2006 ◽  
Vol 61 (4) ◽  
pp. 413-419 ◽  
Author(s):  
Renata Jakše ◽  
David Bevk ◽  
Amalija Golobič ◽  
Jurij Svete ◽  
Branko Stanovnik
Keyword(s):  
Thiobarbituric Acid ◽  
Active Methylene ◽  
Methylene Group

Various aplysinopsin and β -carboline thiohydantoin analogues were prepared starting from ethyl 3-formyl-1H-indole-2-carboxylate by condensation with the active methylene group of 2-thiohydantoin, rhodanine, or thiobarbituric acid derivatives

THIAZOLIDINEDIONES: REACTIVITY OF THE ACTIVE METHYLENE GROUP

1997 ◽  
Vol 3 (4) ◽  
Author(s):  
V.L.M. GUARDA ◽  
M. PERRISSIN ◽  
I.R. PITTA ◽  
S.L. GALDINO ◽  
C. LUU DUC
Keyword(s):  
Active Methylene ◽  
Methylene Group

Heterocyclization of thioamides containing an active methylene group (review)

2008 ◽  
Vol 44 (12) ◽  
pp. 1429-1459 ◽  
Author(s):  
V. N. Britsun ◽  
A. N. Esipenko ◽  
M. O. Lozinskii
Keyword(s):  
Active Methylene ◽  
Methylene Group

Chemistry and Tautomerism of Coupling Products of Diazotised Sulfamethoxazole with some Compounds Containing an Active Methylene Group

2002 ◽  
Vol 2002 (2) ◽  
pp. 64-65 ◽  
Author(s):  
Saber M. Hassan ◽  
Hussein A. Emam ◽  
Mohamed A. Habib
Keyword(s):  
Azo Compounds ◽  
Active Methylene ◽  
Methylene Group

Azo compounds (2–5) bearing a sulfamethoxazole moiety were prepared. The action of hydrazinecarbodithioate derivatives on (2–4) afforded pyrazoledithiocarboxylates (8–10).

scholarly journals [1,5]-Hydride Shift-Cyclization versus C(sp2)-H Functionalization in the Knoevenagel-Cyclization Domino Reactions of 1,4- and 1,5-Benzoxazepines

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1265 ◽  
Author(s):  
Dóra Szalóki Vargáné ◽  
László Tóth ◽  
Balázs Buglyó ◽  
Attila Kiss-Szikszai ◽  
Attila Mándi ◽  
...  
Keyword(s):  
Density Functional ◽  
Time Dependent ◽  
Chiral Hplc ◽  
Cyclization Reactions ◽  
Substitution Pattern ◽  
Functional Theory ◽  
Hydride Shift ◽  
Ic50 Value ◽  
Active Methylene ◽  
Methylene Group

Domino cyclization reactions of N-aryl-1,4- and 1,5-benzoxazepine derivatives involving [1,5]-hydride shift or C(sp2)-H functionalization were investigated. Neuroprotective and acetylcholinesterase activities of the products were studied. Domino Knoevenagel-[1,5]-hydride shift-cyclization reaction of N-aryl-1,4-benzoxazepine derivatives with 1,3-dicarbonyl reagents having active methylene group afforded the 1,2,8,9-tetrahydro-7bH-quinolino [1,2-d][1,4]benzoxazepine scaffold with different substitution pattern. The C(sp3)-H activation step of the tertiary amine moiety occurred with complete regioselectivity and the 6-endo cyclization took place in a complete diastereoselective manner. In two cases, the enantiomers of the chiral condensed new 1,4-benzoxazepine systems were separated by chiral HPLC, HPLC-ECD spectra were recorded, and absolute configurations were determined by time-dependent density functional theory- electronic circular dichroism (TDDFT-ECD) calculations. In contrast, the analogue reaction of the regioisomeric N-aryl-1,5-benzoxazepine derivative did not follow the above mechanism but instead the Knoevenagel intermediate reacted in an SEAr reaction [C(sp2)-H functionalization] resulting in a condensed acridane derivative. The AChE inhibitory assays of the new derivatives revealed that the acridane derivative had a 6.98 μM IC50 value.

Coordination chemistry of anticrowns. Complexation of cyclic trimeric perfluoro-o-phenylenemercury (o-C6F4Hg)3 with compounds containing an active methylene group

2013 ◽  
Vol 62 (3) ◽  
pp. 710-715 ◽  
Author(s):  
I. A. Tikhonova ◽  
A. A. Yakovenko ◽  
K. I. Tugashov ◽  
F. M. Dolgushin ◽  
P. V. Petrovskii ◽  
...  
Keyword(s):  
Coordination Chemistry ◽  
Active Methylene ◽  
Methylene Group
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