Rat serum hydrolases cleaving N-acetyl-L-tyrosine ethyl ester

1974 ◽  
Vol 39 (7) ◽  
pp. 1925-1932
Author(s):  
E. Simonianová ◽  
M. Petáková
Keyword(s):  
Ethyl Ester ◽  
Rat Serum

Inhibition of passive anaphylaxis induced in the rat hind paw and peritoneal cavity by N-(2-oxo-3,5,7-cycloheptatrien-l-yl)-aminooxoacetic acid ethyl ester (AY-25,674)

1978 ◽  
Vol 56 (6) ◽  
pp. 1005-1010 ◽  
Author(s):  
R. R. Martel ◽  
J. Klicius ◽  
J. Pinski
Keyword(s):  
Mast Cells ◽  
Ethyl Ester ◽  
Peritoneal Cavity ◽  
Immunoglobulin E ◽  
Acid Ethyl Ester ◽  
Disodium Cromoglycate ◽  
Activity Profile ◽  
Rat Serum ◽  
Short Time ◽  
Orally Active

Passive anaphylaxis induced in the rat hind paw and peritoneal cavity with rat serum containing immunoglobulin E antibody was inhibited by N-(2-oxo-3,5,7-cycloheptatrien-1-yl)-aminooxoacetic acid ethyl ester (AY-25,674). In contrast with disodium cromoglycate (DSCG), AY-25,674 was orally active. Otherwise, the activity profile of AY-25,674 was similar to that of DSCG. Peak activity occurred a short time after administration, large doses produced tachyphylaxis, and anaphylactic histamine release from mast cells was inhibited. AY-25,674 did not inhibit increased vascular permeability produced by nonreaginic antibody, compound 48/80, serotonin, or histamine. It is concluded that AY-25,674 produces its antiallergic effects by inhibiting mediator release from mast cells by a mechanism similar to that of DSCG.

Rat serum and liver homogenate enzymes splitting N-acetyl-L-tyrosine ethyl ester

1968 ◽  
Vol 33 (10) ◽  
pp. 3366-3371
Author(s):  
M. Petáková ◽  
E. Simonianová ◽  
O. Jozová ◽  
M. Rybák ◽  
J. Hladovec
Keyword(s):  
Ethyl Ester ◽  
Liver Homogenate ◽  
Rat Serum

FUNCTIONAL HETEROGENEITY OF THE THYROID AND POSSIBLE PRESENCE OF IODOTYROSINE-LIKE COMPOUNDS IN NORMAL SERUM

1965 ◽  
Vol 48 (2) ◽  
pp. 199-208 ◽  
Author(s):  
J. D. Wiener
Keyword(s):  
Human Subjects ◽  
Thyroid Tissue ◽  
Normal Serum ◽  
Schematic Model ◽  
Functional Heterogeneity ◽  
Rat Serum ◽  
Iodine Metabolism ◽  
Normal Rat ◽  
Isotope Equilibrium ◽  
Equilibrium Experiment

ABSTRACT After the administration of 131I to normal animals or human subjects, labelled thyroxine and triiodothyronine, but at most traces of labelled iodotyrosines can be detected in the serum. However, several investigators using various methods claim to have found considerable amounts of one or both of these iodotyrosines when assaying the stable (non-radioactive) iodinated compounds in the serum. Considering the available evidence as convincing for the present, an attempt has been made to explain this discrepancy. A schematic model of the thyroidal iodine metabolism is proposed, based on (a) the hypothesis that the iodotyrosines are present in the circulation in a »masked« form (i. e. protected against deiodination), and (b) the known functional heterogeneity of the thyroid tissue. This heterogeneity should be of a qualitative as well as quantitative nature. As the physical decay rate of 131I is short in comparison with the turnover rate of the masked iodotyrosine pool, an isotope equilibrium experiment with rats was carried out, using the long-lived isotope 125I. The results of this experiment, viewed together with those of a similar investigation published by others, seem to lend support to the proposed mechanism. The presence of non-negligible amounts of a diiodotyrosine-like compound in normal rat serum seems fairly well established.

TSH DETERMINATION IN RAT SERUM BY A HOMOLOGOUS RADIOIMMUNOASSAY

1974 ◽  
Vol 77 (1_Suppl) ◽  
pp. S127
Author(s):  
J. Golstein ◽  
L. Vanhaelst ◽  
M. Bonnyns ◽  
G. Rothenbuchner
Keyword(s):  
Rat Serum

Regulation of insulin-like growth factor-binding protein-1 in rat serum

Diabetes ◽  
1994 ◽  
Vol 43 (2) ◽  
pp. 232-239 ◽  
Author(s):  
M. S. Lewitt ◽  
H. Saunders ◽  
J. L. Phyual ◽  
R. C. Baxter
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Rat Serum ◽  
Factor Binding
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