Synthesis of p-bis-silylarylene compounds by the Grignard reaction of p-dichlorobenzene with dialkoxy-, dichloro-, alkoxychloro- and chlorodiphenylsilanes

1974 ◽  
Vol 39 (7) ◽  
pp. 1728-1734 ◽  
Author(s):  
V. Bažant ◽  
M. Černý
Keyword(s):  
Grignard Reaction

Halogenation of ORMOSIL: A Promising Rout for Tailoring Optical Absorptions

2003 ◽  
Vol 771 ◽  
Author(s):  
Amir Fardad ◽  
Wei Liang ◽  
Yadong Zhang ◽  
Bryson Case ◽  
Shibin Jiang ◽  
...  
Keyword(s):  
Process Parameters ◽  
Sol Gel ◽  
Fiber Amplifiers ◽  
Grignard Reaction ◽  
Coupling Loss ◽  
Beam Splitters ◽  
Silicon Technology ◽  
Sol Gel Process ◽  
Propagation Losses ◽  
Signal Intensities

AbstractFluorinated and photo-imageable precursors are synthesized through a Barbier-Grignard reaction for 1550-nm window. The precursors are used for the sol-gel process of integrated optic components for silica-on-silicon technology. Material compositions and process parameters are optimized to achieve internal absorptions >0.1 dB/cm and propagation losses of about 0.5 dB/cm at 1550 nm. Compact 1×16 Beam splitters are designed and fabricated which exhibit >0.3 dB power uniformity, >0.1 dB PDL and 1.5 dB coupling loss. By hybrid integration of the passive splitters and in-house fiber amplifiers, amplifying splitters are demonstrated at various signal intensities.

scholarly journals Multistep batch-flow hybrid synthesis of a terbinafine precursor

2021 ◽  
Author(s):  
Tamás Hergert ◽  
Béla Mátravölgyi ◽  
Róbert Örkényi ◽  
János Éles ◽  
Ferenc Faigl
Keyword(s):  
Methyl Ether ◽  
Lithium Salt ◽  
Scale Up ◽  
Hybrid Process ◽  
High Yield ◽  
Grignard Reaction ◽  
Efficient Synthesis ◽  
Synthetic Process ◽  
Synthesis Route ◽  
Selective Addition

AbstractA three-step batch-flow hybrid process has been developed for an expeditious synthesis of the enynol key intermediate of antifungal terbinafine. This procedure involves consecutive organometallic steps without the necessity of any in-line purification: after a metalation by n-butyllithium, a selective addition of the lithium salt was elaborated followed by a Grignard reaction resulting in a high yield of 6,6-dimethylhept-1-en-4-yn-3-ol. Moreover, as an alternative to tetrahydrofuran, cyclopentyl methyl ether was used as solvent implementing a safe, sustainable, yet selective synthetic process. Even on a laboratory-scale, the optimized batch-flow hybrid process had a theoretical throughput of 41 g/h. Furthermore, the newly developed process provides an efficient synthesis route to the key-intermediate, while making acrolein obsolete, minimizing side-products, and enabling safe and convenient scale-up.

Endoperoxidation of 9,10-Bis-(1-hydroxyalkyl)anthracenes and Successive Formation of 9,10-Anthraquinone under Grignard Reaction Conditions

Heterocycles ◽  
2004 ◽  
Vol 62 (1) ◽  
pp. 153 ◽  
Author(s):  
Shigeyasu Kuroda ◽  
Mitsunori Oda ◽  
Hiroki Syumiya ◽  
Shah M. I. Shaheen ◽  
Ryuta Miyatake ◽  
...  
Keyword(s):  
Grignard Reaction ◽  
Reaction Conditions ◽  
Successive Formation

Preparation of β-Substituted γ-Keto Esters by the Grignard Reaction on N-Acylpyrazoles

Heterocycles ◽  
2001 ◽  
Vol 54 (1) ◽  
pp. 309 ◽  
Author(s):  
Choji Kashima ◽  
Yoshie Shirahata ◽  
Yoshihiro Tsukamoto
Keyword(s):  
Grignard Reaction ◽  
Keto Esters
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