Amino sugars. XXVII. The synthesis of derivatives of 3-amino-3,4,6-trideoxy-D- or L-xylo-hexopyranose

1972 ◽  
Vol 37 (9) ◽  
pp. 2985-2993 ◽  
Author(s):  
K. Kefurt ◽  
K. Čapek ◽  
J. Čapková ◽  
Z. Kefurtová ◽  
J. Jarý
Keyword(s):  
Amino Sugars ◽  
Derivatives Of

scholarly journals Amino-sugars enhance recognition and phagocytosis of particles by human neutrophils

Blood ◽  
1983 ◽  
Vol 62 (3) ◽  
pp. 697-701 ◽  
Author(s):  
RL Doolittle ◽  
CH Packman ◽  
MA Lichtman
Keyword(s):  
Human Neutrophils ◽  
Amino Sugars ◽  
Carbohydrate Binding ◽  
Carbohydrate Recognition ◽  
Membrane Structures ◽  
Fluorescent Beads ◽  
Amino Derivatives ◽  
Recognition Systems ◽  
Dose Dependent ◽  
Derivatives Of

Abstract Neutrophils were examined for their ability to recognize and ingest beads coated with amino-derivatives of glucose, mannose, and galactose. Radioactive or fluorescent beads coated with any of the three sugars were ingested to an extent three times that observed with albumin- coated beads. Enhancement of ingestion of sugar-coated beads was much more evident when examined by electron micrographic studies. Inclusion of glucose or mannose in the medium with glucose- or mannose-coated beads caused a dose-dependent reduction of ingestion to control levels, but ingestion of galactose-coated beads was poorly inhibited. Similarly, galactose or fucose (6-deoxy-galactose) markedly inhibited ingestion of galactose-coated beads, but caused only a slight decrease in ingestion of glucose- or mannose-coated beads. Thus, neutrophils possess carbohydrate-binding membrane structures that can mediate recognition and ingestion of sugar-coated beads. Such carbohydrate recognition systems may underlie certain interactions of neutrophils and other surfaces.

Anomeric Equilibria in Derivatives of Amino Sugars. Some 2-Amino-2-deoxy-D-hexose Derivatives1-3

1966 ◽  
Vol 31 (12) ◽  
pp. 4022-4025 ◽  
Author(s):  
Derek Horton ◽  
Jon S. Jewell ◽  
Kerstin D. Philips
Keyword(s):  
Amino Sugars ◽  
Derivatives Of

Preparation of bisulphite addition compounds of 5-Amino-5-deoxy-D-xylose

1966 ◽  
Vol 19 (4) ◽  
pp. 667 ◽  
Author(s):  
DL Ingles
Keyword(s):  
Amino Acid ◽  
Free Amino ◽  
Amino Sugar ◽  
Barium Hydroxide ◽  
Free Sugar ◽  
Amino Sugars ◽  
Addition Compound ◽  
Derivatives Of

Sulphurous acid alone and in admixture with other stronger acids has been used to hydrolyse 5-amino, 5-N-cyclohexylamino, and 5-N-piperidino derivatives of 5-deoxy-l,2-O-isopropylidene-D-xylose. The bisulphite addition compounds of the corresponding amino sugars were thus isolated. Similarly, methyl 5-amino-5-deoxy- 2,3-O-isopropylidene-D-riboside was hydrolysed to yield the bisulphite addition compound of 5-amino-5-deoxy-D-ribose. Treatment of the bisulphite addition compound of 5-amino-5-deoxy-D-xylose with barium hydroxide gave the free amino sugar as a syrup in 96% yield. Removal of bisulphite from the addition compound of 5-X-cyclohexylamino-5-deoxy-D-xylose gave the free sugar in 30% yield together with an amino acid (XVI).

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