Substances with antineoplastic activity. L. N-[δ-(2-amino-6-purinylthio)valeryl]amino acids, their ethyl esters and analogous derivatives of di- and triglycine

1972 ◽  
Vol 37 (8) ◽  
pp. 2606-2610 ◽  
Author(s):  
A. Černý ◽  
R. Kotva ◽  
M. Semonský
Keyword(s):  
Amino Acids ◽  
Ethyl Esters ◽  
Antineoplastic Activity ◽  
Derivatives Of

ChemInform Abstract: β-AMINOKETONES - DERIVATIVES OF α-AMINO ACIDS. II. N-(β-(P-SUBSTITUTED BENZOYL)-ETHYL)-D-α-ALANINE, GLYCINE, AND THEIR ETHYL ESTERS

1980 ◽  
Vol 11 (24) ◽  
Author(s):  
A. G. AGABABYAN ◽  
G. A. GEVORGYAN ◽  
L. P. PODOLSKAYA ◽  
T. O. ASATRYAN ◽  
N. A. APOYAN ◽  
...  
Keyword(s):  
Amino Acids ◽  
Ethyl Esters ◽  
Derivatives Of

1-Substitution derivatives of 4-aryl-2,3-dibromo-1-naphthol

1981 ◽  
Vol 46 (9) ◽  
pp. 2116-2122 ◽  
Author(s):  
Jiří Křepelka ◽  
Jiří Roubík ◽  
Jiří Holubek
Keyword(s):  
Aqueous Medium ◽  
Ethyl Esters ◽  
Derivatives Of

Alkylation of 7-ethyl-4-(4-ethylphenyl)-2,3-dibromo-1-naphthol (I) with ethyl esters of ω-bromoalkanoic acids XX-XXIII in a non-aqueous medium gave the 1-substitution derivatives II, IV, VI and VIII which were hydrolyzed to the acids III, V, VII and IX. The acid III was used for syntheses of the esters X-XIII and amides XIV-XVIII. Compounds II-XVIII exhibited moderate antineoplastic effects in animals with transplanted tumours; best results were observed with the compound II.

Some 2-substitution derivatives of 5-(4-oxo-6-hydroxy-3,4-dihydro-5-pyrimidinyl)pentanoic acid

1983 ◽  
Vol 48 (1) ◽  
pp. 304-311 ◽  
Author(s):  
Jiří Křepelka ◽  
Jan Beneš ◽  
Vladimír Pouzar ◽  
Jaroslav Vachek ◽  
Jiří Holubek
Keyword(s):  
Nitrile Group ◽  
Antineoplastic Activity ◽  
Carboxyl Group ◽  
Positional Isomers ◽  
Pentanoic Acid ◽  
Pharmacological Tests ◽  
Derivatives Of

Condensation of triethyl ester of 1,1,5-pentanetricarboxylic acid (XI) with substituted guanidines XXII - XXIX gave acids II - IX, which were converted into esters XI - XIX. The acid II and the ester XI were obtained as mixtures of positional isomers. Analogously, condensation of the triester XXI with dicyanodiamide gave rise to acid X, whose nitrile group, under conditions of esterification of a carboxyl group, produced iminoether XX. In pharmacological tests for antineoplastic activity the compounds prepared exhibited weaker efficacy than 5-(2-amino-6-hydroxy-4-oxo-3,4-dihydro-5-pyrimidinyl)pentanoic acid (I), employed as standard.

Derivatives of aminoquinones with N-protected amino acids

1998 ◽  
Vol 5 (4) ◽  
pp. 259-262 ◽  
Author(s):  
Chrysostomos Pachatouridis ◽  
Elias A. Couladouros ◽  
Vassilios P. Papageorgiou ◽  
Maria Liakopoulou-Kyriakides
Keyword(s):  
Amino Acids ◽  
Derivatives Of
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