On terpenes. CCVII. Contribution to the stereochemistry of substances with daucane skeleton and the determination of absolute configuration of laserpitin

1970 ◽  
Vol 35 (12) ◽  
pp. 3597-3609 ◽  
Author(s):  
M. Holub ◽  
J. Tax ◽  
P. Sedmera ◽  
F. Šorm
Keyword(s):  
Absolute Configuration ◽  
Determination Of Absolute Configuration

Prismatomerin, a New Iridoid fromPrismatomeristetrandra. Structure Elucidation, Determination of Absolute Configuration, and Cytotoxicity

2007 ◽  
Vol 70 (8) ◽  
pp. 1339-1343 ◽  
Author(s):  
Karsten Krohn ◽  
Dietmar Gehle ◽  
Sujit Kumar Dey ◽  
Nilufar Nahar ◽  
Mohammed Mosihuzzaman ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
Structure Elucidation ◽  
Determination Of Absolute Configuration

(-)-Strempeliopine, stereoselective total synthesis and the determination of absolute configuration

1986 ◽  
Vol 51 (8) ◽  
pp. 1731-1742 ◽  
Author(s):  
Josef Hájíček ◽  
Jan Trojánek
Keyword(s):  
Circular Dichroism ◽  
Total Synthesis ◽  
Absolute Configuration ◽  
Determination Of Absolute Configuration ◽  
Natural Base ◽  
The Absolute ◽  
Circular Dichroïsm

A synthesis of (±)-strempeliopine (II) is described, the key step of which is the stereoselective reductive rearrangement of 18-methylene-1,2-dehydroaspidospermidine (XI). The absolute configuration of the natural (-)-base II was determined as (2S, 7R, 20R, 21R) on the basis of its synthesis from (+)-18-methylenevincadifformine (XVII) the configuration of which was derived from a comparison of circular dichroism properties of bases with a β-anilinoacrylate chromophore. The biogenesis of the alkaloids of the schizozygane type is discussed.

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