Properties of sodium bis(2-methoxyethoxy)aluminium hydride. IX. Reduction and hydrogenolysis of amino-substituted aromatic aldehydes, ketones, carboxylic acids, esters, and carbinols

1970 ◽  
Vol 35 (4) ◽  
pp. 1216-1223 ◽  
Author(s):  
M. Černý ◽  
J. Málek
Keyword(s):  
Carboxylic Acids ◽  
Aromatic Aldehydes

Synthesis of 3-(Cyclohexylamino)-2-arylimidazo[1,2-a]pyridine-8- carboxylic Acids Via an Efficient Three-component Condensation Reaction between Cyclohexylisocyanide and 2-Aminopyridine-3-carboxylic Acid in the Presence of Aromatic Aldehyde

2018 ◽  
Vol 21 (4) ◽  
pp. 298-301 ◽  
Author(s):  
Ghasem Marandi
Keyword(s):  
Biological Sciences ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
High Performance ◽  
Condensation Reaction ◽  
Aromatic Aldehydes ◽  
New Materials ◽  
One Pot ◽  
High Yields ◽  
Benzaldehyde Derivatives

Aim and Objective: The reaction of cyclohexylisocyanide and 2-aminopyridine-3- carboxylic acid in the presence of benzaldehyde derivatives in ethanol led to 3-(cyclohexylamino)-2- arylimidazo[1,2-a]pyridine-8-carboxylic acids in high yields. In a three component condensation reaction, isocyanide reacts with 2-aminopyridine-3-carboxylic acid and aromatic aldehydes without any prior activation. Material and Methods: The synthesized products have stable structures which have been characterized by IR, 1H, 13C and Mass spectroscopy as well as CHN-O analysis. Results: In continuation of our attempts to develop simple one-pot routes for the synthesis of 3- (cyclohexylamino)-2-arylimidazo[1,2-a]pyridine-8-carboxylic acids, aromatic aldehydes with divers substituted show a high performance. Conclusion: In conclusion, this study introduces the art of combinatorial chemistry using a simple one-pot procedure for the synthesis of new materials which are interesting compounds in medicinal and biological sciences.

Oxidation of heterocyclic and aromatic aldehydes to the corresponding carboxylic acids by Acetobacter and Serratia strains

2004 ◽  
Vol 26 (21) ◽  
pp. 1643-1648 ◽  
Author(s):  
Koichi Mitsukura ◽  
Yukihide Sato ◽  
Toyokazu Yoshida ◽  
Toru Nagasawa
Keyword(s):  
Carboxylic Acids ◽  
Aromatic Aldehydes

One Pot Synthesis of 6-(4-carboxy-3-methyl-2-phenylquinolin-6-ylsulfonyl)-3-methyl-2-phenylquinoline-4-carboxylic Acids from Dapsone and α-ketobutyric Acid by a Doebner Reaction

2016 ◽  
Vol 40 (12) ◽  
pp. 715-717 ◽  
Author(s):  
Negar Moshref Javadi ◽  
Javad Azizian
Keyword(s):  
Biological Activity ◽  
Carboxylic Acids ◽  
Anticancer Agents ◽  
Spectroscopic Data ◽  
Aromatic Aldehydes ◽  
Reaction Conditions ◽  
One Pot ◽  
Promising Alternative ◽  
Elemental Analyses ◽  
Operational Simplicity

A series of new 6-(4-carboxy-3-methyl-2-phenylquinolin-6-ylsulfonyl)-3-methyl-2-phenylquinoline-4-carboxylic acids were synthesised by a one-pot reaction of dapsone, α-ketobutyric acid, and aromatic aldehydes in the presence of CuBr2 as a catalyst. Operational simplicity, mild reaction conditions, and eco-friendly procedure make this novel protocol a promising alternative for the preparation of quinoline-4-caboxylic acid derivatives. The structures of the products were established by elemental analyses and spectroscopic data. The biological activity of the new sulfone dimers was evaluated as having the potential for use as anticancer agents.

scholarly journals Anomalous surface-enhanced Raman scattering of aromatic aldehydes and carboxylic acids

2016 ◽  
Vol 48 (3) ◽  
pp. 413-417 ◽  
Author(s):  
N. F. L. Machado ◽  
M. P. M. Marques ◽  
L. A. E. Batista de Carvalho ◽  
J. L. Castro ◽  
J. C. Otero
Keyword(s):  
Raman Scattering ◽  
Carboxylic Acids ◽  
Aromatic Aldehydes ◽  
Surface Enhanced Raman Scattering ◽  
Anomalous Surface ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

scholarly journals Silver(I) as a widely applicable, homogeneous catalyst for aerobic oxidation of aldehydes toward carboxylic acids in water—“silver mirror”: From stoichiometric to catalytic

2015 ◽  
Vol 1 (2) ◽  
pp. e1500020 ◽  
Author(s):  
Mingxin Liu ◽  
Haining Wang ◽  
Huiying Zeng ◽  
Chao-Jun Li
Keyword(s):  
Natural Products ◽  
Carboxylic Acids ◽  
Atmospheric Oxygen ◽  
Aerobic Oxidation ◽  
Aromatic Aldehydes ◽  
Catalyst Loading ◽  
Homogeneous Catalyst ◽  
Reaction Conditions ◽  
Silver Mirror ◽  
High Yields

The first example of a homogeneous silver(I)-catalyzed aerobic oxidation of aldehydes in water is reported. More than 50 examples of different aliphatic and aromatic aldehydes, including natural products, were tested, and all of them successfully underwent aerobic oxidation to give the corresponding carboxylic acids in extremely high yields. The reaction conditions are very mild and greener, requiring only a very low silver(I) catalyst loading, using atmospheric oxygen as the oxidant and water as the solvent, and allowing gram-scale oxidation with only 2 mg of our catalyst. Chromatography is completely unnecessary for purification in most cases.

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