Nucleic acids components and their analogues. LXXVII. Synthesis of anomeric 1-(2-deoxy-D-ribofuranosyl) and 1-(D-ribofuranosyl) derivatives of 5-hydroxymethyluracil

1966 ◽  
Vol 31 (3) ◽  
pp. 1053-1063 ◽  
Author(s):  
M. Prystaš ◽  
F. Šorm
Keyword(s):  
Nucleic Acids ◽  
Derivatives Of

Nucleic acids. 16. Orally active derivatives of ara-cytidine

1976 ◽  
Vol 19 (8) ◽  
pp. 1013-1017 ◽  
Author(s):  
W. J. Wechter ◽  
D. T. Gish ◽  
M. E. Greig ◽  
G. D. Gray ◽  
T. E. Moxley ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Orally Active ◽  
Derivatives Of

Synthesis of Oligobipyridine Strands Bearing Nucleoside and Amino Acid Side Chains

1996 ◽  
Vol 49 (10) ◽  
pp. 1023 ◽  
Author(s):  
MM Harding ◽  
JM Lehn
Keyword(s):  
Amino Acid ◽  
Nucleic Acids ◽  
Organic Solvents ◽  
Metal Ion ◽  
Metal Ion Complexation ◽  
Biological Targets ◽  
Complexation Studies ◽  
Amide Derivatives ◽  
Amino Acid Side Chains ◽  
Derivatives Of

The synthesis is reported of derivatives of 6,6'-dimethyl-2,2'-bipyridine in which adenosine, thymidine aid tryptophan substituents are introduced at the 4,4'-positions as amide derivatives. Artificial oligonucleoside strands derived from the corresponding trisbipyridyl ligand , in which three bipyridyl ligands are separated by methyleneoxy bridges, have been prepared. The solubility of the nucleoside-substituted ligands in organic solvents is poor, but acylation of the ribose or deoxyribose units present in the ligands provides a mechanism whereby organic solubility can be improved. These ligands may be used for the preparation of metallo-exoreceptors , with the potential for recognition of biological targets such as nucleic acids. Preliminary metal ion complexation studies have been carried out.

ChemInform Abstract: NUCLEIC ACIDS. 16. ORALLY ACTIVE DERIVATIVES OF ARA-CYTIDINE

1976 ◽  
Vol 7 (49) ◽  
pp. no-no
Author(s):  
W. J. WECHTER ◽  
D. T. GISH ◽  
M. E. GREIG ◽  
G. D. GRAY ◽  
T. E. MOXLEY ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Orally Active ◽  
Derivatives Of
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