Incorporation of amino acids into the soluble ribonucleic acids of the cytoplasm, nucleus and mitochondria of rat liver

1964 ◽  
Vol 29 (10) ◽  
pp. 2543-2548 ◽  
Author(s):  
N. R. Elaev ◽  
Č. Altaner
Keyword(s):  
Amino Acids ◽  
Rat Liver ◽  
Ribonucleic Acids

scholarly journals Alterations of lysosomal size and density during rat liver perfusion. Suppression by insulin and amino acids.

1977 ◽  
Vol 252 (19) ◽  
pp. 6948-6954 ◽  
Author(s):  
A N Neely ◽  
J R Cox ◽  
J A Fortney ◽  
C M Schworer ◽  
G E Mortimore
Keyword(s):  
Amino Acids ◽  
Rat Liver ◽  
Liver Perfusion ◽  
Rat Liver Perfusion

EFFECTS OF HYPOGLYCIN A ON THE METABOLISM OF AMINO ACIDS BY LIVER SLICES

1964 ◽  
Vol 42 (1) ◽  
pp. 139-142 ◽  
Author(s):  
S. J. Patrick ◽  
L. C. Stewart
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Glutamic Acid ◽  
Rat Liver ◽  
Inhibitory Effects ◽  
Liver Slices

The effects of hypoglycin A on the metabolism of L-leucine-C14, L-alanine-C14, and L-glutamic-acid-C14 by rat liver slices have been investigated. Hypoglycin exerted markedly inhibitory effects on the conversion of leucine-C14 to fatty acid, cholesterol, and CO2. Conversion of alanine-C14 and glutamic acid-C14 to fatty acids was also inhibited by hypoglycin. No effects of hypoglycin on the conversion of C14-amino acids into protein or glycogen were demonstrated.

scholarly journals Accumulation of amino acids by the perfused rat liver in the presence of ethanol

1973 ◽  
Vol 134 (3) ◽  
pp. 697-705 ◽  
Author(s):  
Hans A. Krebs ◽  
Reginald Hems ◽  
Patricia Lund
Keyword(s):  
Amino Acids ◽  
Rat Liver ◽  
Major Effect ◽  
Major Product ◽  
Control Mechanisms ◽  
Perfused Rat Liver ◽  
Carbamoyl Phosphate ◽  
Lactate Formation ◽  
Gluconeogenesis From Alanine ◽  
Almost All

1. The rate of gluconeogenesis from alanine in the perfused rat liver is affected by the presence of other metabolizable substances, especially fatty acids, ornithine and ethanol. Gluconeogenesis is accelerated by oleate and by ornithine. When both oleate and ornithine were present the acceleration was greater than expected on the basis of mere additive effects. 2. Much NH3 and some urea were formed from alanine when no ornithine was added. With ornithine almost all the nitrogen released from alanine appeared as urea. 3. Lactate was a major product of alanine metabolism. Addition of oleate, and especially of oleate plus ornithine, decreased lactate formation. 4. Ethanol had no major effect on gluconeogenesis from alanine when this was the sole added precursor. Gluconeogenesis was strongly inhibited (87%) when oleate was also added, but ethanol greatly accelerated gluconeogenesis when ornithine was added together with alanine. 5. In the absence of ethanol the alanine carbon and alanine nitrogen removed were essentially recovered in the form of glucose, lactate, pyruvate, NH3 and urea. 6. In the presence of ethanol the balance of both alanine carbon and alanine nitrogen showed substantial deficits. These deficits were largely accounted for by the formation of aspartate and glutamine, the formation of which was increased two- to three-fold. 7. When alanine was replaced by lactate plus NH4Cl, ethanol also caused a major accumulation of amino acids, especially of aspartate and alanine. 8. Earlier apparently discrepant results on the effects of ethanol on gluconeogenesis from alanine are explained by the fact that under well defined conditions ethanol can inhibit, or accelerate, or be without major effect on the rate of gluconeogenesis. 9. It is pointed out that in the synthesis of urea through the ornithine cycle half of the nitrogen must be supplied in the form of asparate and half in the form of carbamoyl phosphate. The accumulation of aspartate and other amino acids suggests that ethanol interferes with the control mechanisms which regulate the stoicheiometric formation of aspartate and carbamoyl phosphate.

scholarly journals Metabolic Studies of Amino Acids by Rat Liver Cells in Primary Culture

1978 ◽  
Vol 31 (6) ◽  
pp. 571-577
Author(s):  
Kyoichi KISHI ◽  
Yoshiaki FUJITA ◽  
Keiji TANAKA ◽  
Akira ICHIHARA
Keyword(s):  
Amino Acids ◽  
Primary Culture ◽  
Rat Liver ◽  
Liver Cells ◽  
Metabolic Studies ◽  
Rat Liver Cells

Studies on pathogenesis of experimental fatty liver (I) variation in the pattern of free amino acids of albino rat liver

1966 ◽  
Vol 1 (1) ◽  
pp. 38-39
Author(s):  
Y. Takaoka ◽  
K. Yokouchi ◽  
G. Mitsuoka ◽  
H. Tajima ◽  
E. Uchiyama ◽  
...  
Keyword(s):  
Amino Acids ◽  
Fatty Liver ◽  
Rat Liver ◽  
Free Amino Acids ◽  
Free Amino ◽  
Albino Rat

Effect of Dietary Amino Acids on Amino Acidcatabolizing Enzymes in Rat Liver

1970 ◽  
Vol 100 (7) ◽  
pp. 827-836 ◽  
Author(s):  
Kiwao Nakano ◽  
Tetsuya Kishi ◽  
Nobuyuki Kurita ◽  
Kiyoshi Ashida
Keyword(s):  
Amino Acids ◽  
Rat Liver ◽  
Dietary Amino Acids
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