Ganglionic blocking agents. II. Bis-quarternary salts derived from 1,5-diamino-3-thiapentane

1955 ◽  
Vol 20 (2) ◽  
pp. 273-277 ◽  
Author(s):  
M. Borovička ◽  
M. Protiva
Keyword(s):  
Blocking Agents ◽  
Ganglionic Blocking

Effect of Sympathetic Blocking Agents on the Toxic Action of O2 at High Pressure

1957 ◽  
Vol 188 (3) ◽  
pp. 593-598 ◽  
Author(s):  
Paul C. Johnson ◽  
John W. Bean
Keyword(s):  
Significant Degree ◽  
The Other ◽  
Lung Damage ◽  
Blocking Agents ◽  
Notable Effect ◽  
Gauge Pressure ◽  
Pulmonary Pathology ◽  
Sympathetic Nervous ◽  
Ganglionic Blocking ◽  
Sympatholytic Agents

The effects of sympathetic blocking agents were studied on rats exposed to O2 at 80 lb. gauge pressure. The ganglionic blocking agents TEAC and hexamethonium reduced the usual convulsive response, lung damage and mortality to a significant degree. On the other hand, the peripheral sympatholytic agents dibenamine, Dibenzyline, and SKF 501 (N-(9-fluorenyl)-N-ethyl-ß-chlorethylamine) lacked a notable effect on the somatic seizure but definitely reduced the pulmonary pathology and mortality. The drug SKF 501 was also found to protect animals exposed to O2 at 80 lb. 80 mm Hg pCO2. But this protection was seen only in the lungs, mortality was about the same as the normals simultaneously exposed. These experiments suggest that hyperactivity of the sympathetic nervous system is the factor primarily responsible for the pulmonary edema and congestion resultant from OHP. It is further indicated that this system also contributes significantly to the hyperoxic seizure and the incidence of mortality.

New Insights on the Mechanisms of Action of Ganglionic Blocking Agents

Physiology ◽  
1990 ◽  
Vol 5 (4) ◽  
pp. 168-172
Author(s):  
VI Skok
Keyword(s):  
Molecular Mechanisms ◽  
Receptor Activation ◽  
Mechanisms Of Action ◽  
Receptor Activity ◽  
Receptor Blockade ◽  
Transmembrane Current ◽  
Blocking Agents ◽  
Ganglionic Blocking

With the use of direct estimations of receptor activity and measurements of agonist-induced transmembrane current, new molecular mechanisms underlying both receptor activation with agonists and receptor blockade with antagonists have been found.

Influence of Ganglionic Blocking Agents on Survival Time in Irradiated Mice

1954 ◽  
Vol 1 (2) ◽  
pp. 176
Author(s):  
Thomas J. Haley ◽  
John Heglin ◽  
Eve McCulloh
Keyword(s):  
Survival Time ◽  
Blocking Agents ◽  
Ganglionic Blocking

Effect of Antispasmodic and Ganglionic Blocking Agents on Mortality Following Electroshock Convulsions in Mice.

1959 ◽  
Vol 101 (4) ◽  
pp. 750-754
Author(s):  
M. L. Torchiana ◽  
K. L. Meckelnburg ◽  
S. E. Mckinney ◽  
C. A. Stone
Keyword(s):  
Blocking Agents ◽  
Ganglionic Blocking
Sign in / Sign up

Export Citation Format

Share Document