The period of induction in the interaction of potassium bromate with stannous chloride

1938 ◽  
Vol 10 ◽  
pp. 93-96
Author(s):  
Binayendra Nath Sen
Keyword(s):  
Stannous Chloride ◽  
Potassium Bromate

A Facile One-Pot Synthesis of 3-Methylbenzisoxazoles via a Key Intermediate of ortho-Ethoxyvinyl Nitroaryls by Domino Rearrangement and Their Anti- Inflammatory Activity

2020 ◽  
Vol 16 (8) ◽  
pp. 1161-1165
Author(s):  
Bashetti Nagaraju ◽  
Jagarlapudi V. Shanmukhakumar ◽  
Nareshvarma Seelam ◽  
Tondepu Subbaiah ◽  
Bethanamudi Prasanna
Keyword(s):  
Stannous Chloride ◽  
Biologically Active ◽  
Inflammatory Activity ◽  
Albino Rats ◽  
One Pot ◽  
Simple Method ◽  
Standard Drug ◽  
Entire Study ◽  
One Pot Synthesis ◽  
Anti Inflammatory

Background: Recently, there has been a lot of scientific interest in exploring the syntheses of oxygen and nitrogen-containing heterocyclic compounds due to their pharmacological activities. In addition, benzisoxazoles play a very important role in organic synthesis as key intermediates. Objective: In this paper, we focused on developing a novel synthetic route for biologically active arylisoxazoles under normal conditions, and simplified it to get high purities and yields, and also reported their anti-inflammatory activities. Method: An efficient and simple method has been explored for the synthesis of novel 3-methyl arylisoxazoles from o-nitroaryl halides via o-ethoxyvinylnitroaryls, using dihydrated stannous chloride (SnCl2.2H2O) in MeOH / EtOAc (1:1) via Domino rearrangement in one pot synthesis. Result: We synthesized novel 3-methylarylisoxazoles from o-nitroarylhalides via o-ethoxyvinylnitroaryls, using dihydrated stannous chloride (SnCl2.2H2O) in MeOH / EtOAc (1:1) via domino rearrangement. In this reduction, nitro group and ethoxy vinyl group change to the functional acyl ketones, followed by hetero cyclization. Here, the reaction proceeds without the isolation of intermediates like 2-acylnitroarenes and 2- acylanilines. All the synthesized compounds were completely characterized by the NMR and mass spectra. The compounds were also explored for their anti-inflammatory activity by carrageenan-induced inflammation in the albino rats (150-200 g) of either sex used in this entire study with the use of Diclofenac sodium as the standard drug. The initial evaluations identified leading targets with good to moderate anti-inflammatory activity. Conclusion: A simple, one-pot and convenient method has been explored for the synthesis of novel 3- methylarylisoxazoles with high purity and reaction yields. All the compounds 3a, 3c, 3d, 3f, 3g and 3h exhibited 51-64% anti-inflammatory activities.

scholarly journals THE EFFECT OF POTASSIUM BROMATE UPON ENZYME ACTION

1918 ◽  
Vol 33 (3) ◽  
pp. 453-462
Author(s):  
I.S. Falk ◽  
C.E.A. Winslow
Keyword(s):  
Potassium Bromate ◽  
Enzyme Action

LVII.—The adsorption of stannous chloride by stannic acid

1923 ◽  
Vol 123 (0) ◽  
pp. 452-456
Author(s):  
George Ernest Collins ◽  
John Kerfoot Wood
Keyword(s):  
Stannous Chloride ◽  
Stannic Acid

Protective Effect of Solutions Containing Polymers Associated with Fluoride and Stannous Chloride on Hydroxyapatite Dissolution

2021 ◽  
pp. 1-8
Author(s):  
Marina Gullo Augusto ◽  
Tamires Maria de Andrade Santos ◽  
Taís Scaramucci ◽  
Idalina Vieira Aoki ◽  
Carlos Rocha Gomes Torres ◽  
...  
Keyword(s):  
Protective Effect ◽  
Sodium Fluoride ◽  
Stannous Chloride ◽  
Deionized Water ◽  
Lower Amount ◽  
Citric Acid Solution ◽  
Solution Ph ◽  
Methacrylate Copolymer ◽  
Total Reaction Time ◽  
Hydroxyapatite Crystals

This study investigated the protective effect of experimental solutions containing 4 polymers (polyoxirane, hydroxypropylmethylcellulose [HPMC], pectin, and an amino methacrylate copolymer [AMC]) in 2 concentrations (low and high) associated or not with sodium fluoride (F; 225 ppm F<sup>–</sup>) or sodium fluoride plus stannous chloride (FS; 800 ppm Sn<sup>2+</sup>) on the dissolution of hydroxyapatite crystals (HA). Deionized water was the control. The pretreated HA was added to a 0.3% citric acid solution (pH 3.8). An automatic titrant machine added aliquots of 0.1 N HCl at a rate of 28 μL/min, in a total reaction time of 5 min. Groups were compared with 2-way ANOVA and Tukey’s test, and concentrations with Student <i>t</i> test (5%). The zeta potential of the HA treated with the solutions was measured. Significant differences were found for both factors and interaction (<i>p</i> &#x3c; 0.0001). The treatments with F and FS solutions resulted in a lower amount of dissolved HA than the control. Among the polymers’ solutions, only AMC was able to reduce the amount of dissolved HA, changing the surface charge of HA to positive. AMC improved the protective effect of F, but it did not affect FS. Polyoxirane and HPMC reduced the protective potential of the FS solution. No differences were found between the concentrations of the polymers. It was concluded that F and FS reduced the amount of dissolved HA. The protective effect of the experimental solutions against HA dissolution was polymer dependent. The F effect was enhanced by its combination with AMC, but the protection of FS was impaired by polyoxirane and HPMC.

Mutations in the VHL gene from potassium bromate-induced rat clear cell renal tumors

2002 ◽  
Vol 187 (1-2) ◽  
pp. 207-214 ◽  
Author(s):  
Yih-Horng Shiao ◽  
Sonie I Kamata ◽  
Leeanne M Li ◽  
Michelle J Hooth ◽  
Anthony B DeAngelo ◽  
...  
Keyword(s):  
Clear Cell ◽  
Potassium Bromate ◽  
Renal Tumors ◽  
Vhl Gene
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