Role of DNA methylation and histone modifications in structural maintenance of heterochromatin domains (chromocenters)

2008 ◽  
Vol 2 (6) ◽  
pp. 590-600 ◽  
Author(s):  
S. A. Golyshev ◽  
P. N. Vichreva ◽  
E. V. Sheval ◽  
G. I. Kiryanov ◽  
V. Yu. Polyakov
Keyword(s):  
Dna Methylation ◽  
Histone Modifications

scholarly journals The role of histone modifications and DNA methylation in renal cell carcinoma development

2012 ◽  
Vol 10 (3) ◽  
pp. 59-76
Author(s):  
Lilia R Kutlyeva ◽  
Irina R Gilayzova ◽  
Rita I Khusainova ◽  
Elsa K Khusnutdinova
Keyword(s):  
Dna Methylation ◽  
Renal Cell Carcinoma ◽  
Gene Regulation ◽  
Cell Carcinoma ◽  
Genomic Imprinting ◽  
Histone Modifications ◽  
Renal Cell ◽  
Human Cancer ◽  
Epigenetic Mechanisms

Epigenetic mechanisms of gene regulation play a key role in carcinogenesis. This review will focus on the recent advances of epigenetic investigations in the development of human cancer. The role of histone modifications, genomic imprinting and DNA methylation in renal cell carcinoma development and progression will be considered.

scholarly journals The Role of DNA Methylation and Histone Modification in Periodontal Disease: A Systematic Review

2020 ◽  
Vol 21 (17) ◽  
pp. 6217
Author(s):  
Ismael Khouly ◽  
Rosalie Salus Braun ◽  
Michelle Ordway ◽  
Bradley Eric Aouizerat ◽  
Iya Ghassib ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dna Methylation ◽  
Periodontal Disease ◽  
Histone Modification ◽  
Histone Modifications ◽  
Disease Risk ◽  
Periodontal Diseases ◽  
Epigenetic Changes ◽  
Human Adults

Despite a number of reports in the literature on the role of epigenetic mechanisms in periodontal disease, a thorough assessment of the published studies is warranted to better comprehend the evidence on the relationship between epigenetic changes and periodontal disease and its treatment. Therefore, the aim of this systematic review is to identify and synthesize the evidence for an association between DNA methylation/histone modification and periodontal disease and its treatment in human adults. A systematic search was independently conducted to identify articles meeting the inclusion criteria. DNA methylation and histone modifications associated with periodontal diseases, gene expression, epigenetic changes after periodontal therapy, and the association between epigenetics and clinical parameters were evaluated. Sixteen studies were identified. All included studies examined DNA modifications in relation to periodontitis, and none of the studies examined histone modifications. Substantial variation regarding the reporting of sample sizes and patient characteristics, statistical analyses, and methodology, was found. There was some evidence, albeit inconsistent, for an association between DNA methylation and periodontal disease. IL6, IL6R, IFNG, PTGS2, SOCS1, and TNF were identified as candidate genes that have been assessed for DNA methylation in periodontitis. While several included studies found associations between methylation levels and periodontal disease risk, there is insufficient evidence to support or refute an association between DNA methylation and periodontal disease/therapy in human adults. Further research must be conducted to identify reproducible epigenetic markers and determine the extent to which DNA methylation can be applied as a clinical biomarker.

scholarly journals The role of DNA methylation and histone modifications in blood pressure: a systematic review

2019 ◽  
Vol 33 (10) ◽  
pp. 703-715 ◽  
Author(s):  
Valentina Gonzalez-Jaramillo ◽  
Eliana Portilla-Fernandez ◽  
Marija Glisic ◽  
Trudy Voortman ◽  
Wichor Bramer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Dna Methylation ◽  
Histone Modifications

scholarly journals Essential roles of Hdac1 and 2 in lineage development and genome-wide DNA methylation during mouse preimplantation development

2019 ◽  
Author(s):  
Panpan Zhao ◽  
Huanan Wang ◽  
Han Wang ◽  
Yanna Dang ◽  
Lei Luo ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Histone Modifications ◽  
Hippo Pathway ◽  
Epigenetic Modifications ◽  
Preimplantation Development ◽  
Global Dna Methylation ◽  
Lineage Specification ◽  
Pluripotent Cells ◽  
Global Methylation

AbstractEpigenetic modifications, including DNA methylation and histone modifications, are reprogrammed considerably following fertilization during mammalian early embryonic development. Incomplete epigenetic reprogramming is a major factor leading to poor developmental outcome in embryos generated by assisted reproductive technologies, such as somatic cell nuclear transfer. However, the role of histone modifications in preimplantation development is poorly understood. Here, we show that co-knockdown (cKD) of Hdac1 and 2 (but not individually) resulted in developmental failure during the morula to blastocyst transition. This outcome was also confirmed with the use of small-molecule Hdac1/2-specific inhibitor FK228. We observed reduced cell proliferation and increased incidence of apoptosis in cKD embryos, which were likely caused by increased acetylation of Trp53. Importantly, both RNA-seq and immunostaining analysis revealed a failure of lineage specification to generate trophectoderm and pluripotent cells. Among many gene expression changes, a substantial decrease of Cdx2 may be partly accounted for by the aberrant Hippo pathway occurring in cKD embryos. In addition, we observed an increase in global DNA methylation, consistent with increased DNA methyltransferases and Uhrf1. Interestingly, deficiency of Rbbp4 and 7 (both are core components of several Hdac1/2-containing epigenetic complexes) results in similar phenotypes as those of cKD embryos. Overall, Hdac1 and 2 play redundant functions required for lineage specification, cell viability and accurate global DNA methylation, each contributing to critical developmental programs safeguarding a successful preimplantation development.SignificanceSubstantial changes to epigenetic modifications occur during preimplantation development and can be detrimental when reprogrammed incompletely. However, little is known about the role of histone modifications in early development. Co-knockdown of Hdac1 and 2, but not individually, resulted in developmental arrest during morula to blastocyst transition, which was accompanied by reduced cell number per embryo and increased incidence of apoptosis. Additionally, we observed a failure of first lineage specification to generate trophectoderm and pluripotent cells, which were associated with reduced expression of key lineage-specific genes and aberrant Hippo pathway. Moreover, an increase in global DNA methylation was found with upregulated Dnmts and Uhrf1. Thus, Hdac1 and 2 play overlapping roles in lineage development, apoptosis, and global methylation during preimplantation development.

The role of DNA methylation, nucleosome occupancy and histone modifications in paramutation

2010 ◽  
Vol 63 (3) ◽  
pp. 366-378 ◽  
Author(s):  
Max Haring ◽  
Rechien Bader ◽  
Marieke Louwers ◽  
Anne Schwabe ◽  
Roel van Driel ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Histone Modifications ◽  
Nucleosome Occupancy

scholarly journals Mealybug Chromosome Cycle as a Paradigm of Epigenetics

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Giorgio Prantera ◽  
Silvia Bongiorni
Keyword(s):  
Dna Methylation ◽  
Histone Modifications ◽  
Insect Species ◽  
Intrinsic Interest ◽  
Chromosome Cycle ◽  
Biological Phenomena ◽  
Epigenetic Phenomenon ◽  
Chromosome Imprinting ◽  
Facultative Heterochromatinization

Recently, epigenetics has had an ever-growing impact on research not only for its intrinsic interest but also because it has been implied in biological phenomena, such as tumor emergence and progression. The first epigenetic phenomenon to be described in the early 1960s was chromosome imprinting in some insect species (sciaridae and coccoideae). Here, we discuss recent experimental results to dissect the phenomenon of imprinted facultative heterochromatinization in Lecanoid coccids (mealybugs). In these insect species, the entire paternally derived haploid chromosome set becomes heterochromatic during embryogenesis in males. We describe the role of known epigenetic marks, such as DNA methylation and histone modifications, in this phenomenon. We then discuss the models proposed to explain the noncanonical chromosome cycle of these species.

scholarly journals A review of epigenetic changes in asthma: methylation and acetylation

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Mojgan Sheikhpour ◽  
Mobina Maleki ◽  
Maryam Ebrahimi Vargoorani ◽  
Vahid Amiri
Keyword(s):  
Dna Methylation ◽  
Histone Modifications ◽  
Histone Methylation ◽  
Epigenetic Changes ◽  
External Effects ◽  
The Past ◽  
Immune Pathways ◽  
Shed Light ◽  
Histone Methylation And Acetylation

AbstractSeveral studies show that childhood and adulthood asthma and its symptoms can be modulated through epigenetic modifications. Epigenetic changes are inheritable modifications that can modify the gene expression without changing the DNA sequence. The most common epigenetic alternations consist of DNA methylation and histone modifications. How these changes lead to asthmatic phenotype or promote the asthma features, in particular by immune pathways regulation, is an understudied topic. Since external effects, like exposure to tobacco smoke, air pollution, and drugs, influence both asthma development and the epigenome, elucidating the role of epigenetic changes in asthma is of great importance. This review presents available evidence on the epigenetic process that drives asthma genes and pathways, with a particular focus on DNA methylation, histone methylation, and acetylation. We gathered and assessed studies conducted in this field over the past two decades. Our study examined asthma in different aspects and also shed light on the limitations and the important factors involved in the outcomes of the studies. To date, most of the studies in this area have been carried out on DNA methylation. Therefore, the need for diagnostic and therapeutic applications through this molecular process calls for more research on the histone modifications in this disease.

Sign in / Sign up

Export Citation Format

Share Document