Production of the Extracellular Part of the ErbB2 Receptor for the Study of Immunobiologicals

2020 ◽  
Vol 46 (3) ◽  
pp. 327-333
Author(s):  
V. S. Rybchenko ◽  
D. S. Balabashin ◽  
A. A. Panina ◽  
O. N. Solopova ◽  
S. A. Yakimov ◽  
...  
Keyword(s):  
Erbb2 Receptor

scholarly journals Expression and function of ErbB receptors and ligands in the pituitary

2011 ◽  
Vol 18 (6) ◽  
pp. R197-R211 ◽  
Author(s):  
Odelia Cooper ◽  
George Vlotides ◽  
Hidenori Fukuoka ◽  
Mark I Greene ◽  
Shlomo Melmed
Keyword(s):  
Anterior Pituitary ◽  
Kinase Inhibitors ◽  
Erbb Receptors ◽  
Receptor Ligands ◽  
Paracrine Effects ◽  
Tumor Subtypes ◽  
Hormonal Secretion ◽  
Gene And Protein Expression ◽  
Erbb2 Receptor ◽  
And Function

The role of ErbB family in discreet pituitary functions is reviewed. Several ErbB receptor ligands, EGF, TGFα, and heregulin are differentially expressed in normal gonadotroph and lacto-somatotroph lineages, and other elements of the anterior pituitary. ErbB receptors, i.e. EGFR and ErbB2, are also localized to the anterior pituitary with preferential EGFR lactosomatotroph expression. EGF regulates CRH and ACTH secretion and corticotroph proliferation as well as exhibiting autocrine and paracrine effects on gonadotrophs and on lactosomatotroph proliferation, gene and protein expression, and hormonal secretion. EGF and EGFR are expressed in both functioning and non-functioning pituitary adenomas, with higher expression in more aggressive tumor subtypes. ErbB2 receptor is detected in all tumor subtypes, particularly in invasive tumors. ErbB tyrosine kinase inhibitors regulate hormonal secretion, cell morphology, and proliferation in lacto-somatotroph tumors, reflecting the emerging application of targeted pituitary therapeutics.

scholarly journals Differential binding of human immunoagents and Herceptin to the ErbB2 receptor

FEBS Journal ◽  
2008 ◽  
Vol 275 (20) ◽  
pp. 4967-4979 ◽  
Author(s):  
Fulvia Troise ◽  
Valeria Cafaro ◽  
Concetta Giancola ◽  
Giuseppe D’Alessio ◽  
Claudia De Lorenzo
Keyword(s):  
Erbb2 Receptor ◽  
Differential Binding

scholarly journals Structural Determinants of the Interaction between the erbB2 Receptor and the Src Homology 2 Domain of Grb7

1997 ◽  
Vol 272 (13) ◽  
pp. 8490-8497 ◽  
Author(s):  
Peter W. Janes ◽  
Martin Lackmann ◽  
W. Bret Church ◽  
Georgina M. Sanderson ◽  
Robert L. Sutherland ◽  
...  
Keyword(s):  
Structural Determinants ◽  
Src Homology 2 ◽  
Erbb2 Receptor ◽  
Src Homology ◽  
Src Homology 2 Domain

scholarly journals Regulation of ERBB2 Receptor by t-DARPP Mediates Trastuzumab Resistance in Human Esophageal Adenocarcinoma

2012 ◽  
Vol 72 (17) ◽  
pp. 4504-4514 ◽  
Author(s):  
Jun Hong ◽  
Ahmed Katsha ◽  
Pengcheng Lu ◽  
Yu Shyr ◽  
Abbes Belkhiri ◽  
...  
Keyword(s):  
Esophageal Adenocarcinoma ◽  
Trastuzumab Resistance ◽  
Erbb2 Receptor
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