H5N1 Virus Targets Pulmonary Endothelial Cells

2012 ◽  
Vol 7 (2) ◽  
pp. 76-76
Keyword(s):  
Endothelial Cells ◽  
H5n1 Virus ◽  
Pulmonary Endothelial Cells

Pulmonary Endothelial Cells / Metabolism of Vasoactive Substances

1975 ◽  
Author(s):  
J. W. Ryan ◽  
Una S. Ryan
Keyword(s):  
Endothelial Cells ◽  
Angiotensin Ii ◽  
Angiotensin I ◽  
Clotting System ◽  
Arterial Circulation ◽  
Pulmonary Endothelial Cells ◽  
Vasoactive Substances ◽  
Metabolic Products ◽  
Relationship Of ◽  
The Relationship

The lungs metabolize a variety of vasoactive substances, including bradykinin (BK), angiotensin I (AT I), PGE2 and F2α, norepinephrine, 5-HT, 5’-ATP and 5’-AMP. In contrast, the lungs od not metabolize angiotensin II (AT II), PGA2, histamine and epinephrine. Of the substances metabolized, all (with the possible exceptions of the prostaglandins) are processed primarily by the pulmonary endothelial cells. Furthermore, the means by which the substances are processed suggest that endothelial cells determine the vasoactive substances allowed to enter the systemic arterial circulation. BK is inactivated while AT I is converted to its potent homolog, AT II. AT II enters the arterial circulation. The metabolism of BK and AT I may be effected by the same enzyme. Pulmonary endothelial cells are a rich source of thromboplastin, an enzyme capable of degrading BK and AT I. However, the relationship of thromboplastin to the fates of these hormones is not clear : The metabolic products produced are not those produced by intact lungs nor by endothelial cells in culture. In addition, thromboplastin degrades substances (e.g. AT II), which are not degraded by intact lungs. Possibly the extrinsic clotting system plays a role when activated but not under physiologic conditions.

Expression of CD34 in Pulmonary Endothelial Cells in vivo1

Pathobiology ◽  
2002 ◽  
Vol 70 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Annette M. Müller ◽  
Maya Nesslinger ◽  
Guido Skipka ◽  
Klaus-Michael Müller
Keyword(s):  
Endothelial Cells ◽  
Pulmonary Endothelial Cells

HDAC Inhibition Causes Apoptosis In Human Pulmonary Endothelial Cells And Lung Fibroblasts

2010 ◽  
Author(s):  
Shiro Mizuno ◽  
Masanori Yasuo ◽  
Harm J. Bogaard ◽  
Donatas Kraskauskas ◽  
Norbert F. Voelkel
Keyword(s):  
Endothelial Cells ◽  
Lung Fibroblasts ◽  
Hdac Inhibition ◽  
Pulmonary Endothelial Cells

Effect of hypoxia on the conversion of angiotensin I to II in cultured porcine pulmonary endothelial cells

1983 ◽  
Vol 32 (7) ◽  
pp. 1201-1205 ◽  
Author(s):  
Peter Szidon ◽  
Suzanne Oparil ◽  
Gene Osikowicz ◽  
Francois M. Booyse
Keyword(s):  
Endothelial Cells ◽  
Angiotensin I ◽  
Pulmonary Endothelial Cells
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