Bacterial Multidrug Efflux Pumps Serve Other Functions

2008 ◽  
Vol 3 (4) ◽  
pp. 179-185 ◽  
Author(s):  
Keith Poole
Keyword(s):  
Efflux Pumps ◽  
Multidrug Efflux ◽  
Multidrug Efflux Pumps

Inhibitors of bacterial multidrug efflux pumps from the resin glycosides of Ipomoea species

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
R Pereda-Miranda ◽  
L Chérigo ◽  
M Fragoso-Serrano ◽  
N Jacobo-Herrera ◽  
GW Kaatz ◽  
...  
Keyword(s):  
Efflux Pumps ◽  
Multidrug Efflux ◽  
Multidrug Efflux Pumps ◽  
Ipomoea Species

Involvement of the Multidrug Efflux Pumps in Betalactams Resistant Pseudomonas aerugionsa Clinical Isolates Collected from Burn Patients in Iran

2016 ◽  
Vol 16 (3) ◽  
pp. 172-177 ◽  
Author(s):  
Aslan Bijari ◽  
Leila Azimi ◽  
Fatemeh Fallah ◽  
Abdollah Ardebili ◽  
Elnaz Lari ◽  
...  
Keyword(s):  
Efflux Pumps ◽  
Clinical Isolates ◽  
Burn Patients ◽  
Multidrug Efflux ◽  
Multidrug Efflux Pumps

scholarly journals Multidrug Efflux Pumps and the Two-Faced Janus of Substrates and Inhibitors

2021 ◽  
Vol 54 (4) ◽  
pp. 930-939
Author(s):  
Helen I. Zgurskaya ◽  
John K. Walker ◽  
Jerry M. Parks ◽  
Valentin V. Rybenkov
Keyword(s):  
Efflux Pumps ◽  
Multidrug Efflux ◽  
Multidrug Efflux Pumps

Physiological Functions of Bacterial “Multidrug” Efflux Pumps

2021 ◽  
Author(s):  
Peter J. F. Henderson ◽  
Claire Maher ◽  
Liam D. H. Elbourne ◽  
Bart A. Eijkelkamp ◽  
Ian T. Paulsen ◽  
...  
Keyword(s):  
Efflux Pumps ◽  
Multidrug Efflux ◽  
Physiological Functions ◽  
Multidrug Efflux Pumps

scholarly journals Gene Cloning and Properties of the RND-Type Multidrug Efflux Pumps MexPQ-OpmE and MexMN-OprM fromPseudomonas aeruginosa

2005 ◽  
Vol 49 (11) ◽  
pp. 999-1002 ◽  
Author(s):  
Takehiko Mima ◽  
Hiroshi Sekiya ◽  
Tohru Mizushima ◽  
Teruo Kuroda ◽  
Tomofusa Tsuchiya
Keyword(s):  
Gene Cloning ◽  
Efflux Pumps ◽  
Multidrug Efflux ◽  
Multidrug Efflux Pumps

Multidrug Efflux Pumps Attenuate the Effect of MGMT Inhibitors

2015 ◽  
Vol 12 (11) ◽  
pp. 3924-3934 ◽  
Author(s):  
Karl-Heinz Tomaszowski ◽  
Ralf Schirrmacher ◽  
Bernd Kaina
Keyword(s):  
Efflux Pumps ◽  
Multidrug Efflux ◽  
Multidrug Efflux Pumps

Multidrug Efflux Pumps

2007 ◽  
pp. 45-69 ◽  
Author(s):  
Helen Zgurskaya ◽  
Olga Lomovskaya ◽  
Kim Lewis ◽  
Keith Bostian
Keyword(s):  
Efflux Pumps ◽  
Multidrug Efflux ◽  
Multidrug Efflux Pumps

scholarly journals Magnitude of Voriconazole Resistance in Clinical and Environmental Isolates of Aspergillus flavus and Investigation into the Role of Multidrug Efflux Pumps

2018 ◽  
Vol 62 (11) ◽  
Author(s):  
Raees A. Paul ◽  
Shivaprakash M. Rudramurthy ◽  
Manpreet Dhaliwal ◽  
Pankaj Singh ◽  
Anup K. Ghosh ◽  
...  
Keyword(s):  
Aspergillus Flavus ◽  
Efflux Pump ◽  
Efflux Pumps ◽  
Azole Resistance ◽  
Wild Type ◽  
Multidrug Efflux ◽  
Environmental Isolates ◽  
Content Type ◽  
Multidrug Efflux Pumps

ABSTRACT The magnitude of azole resistance in Aspergillus flavus and its underlying mechanism is obscure. We evaluated the frequency of azole resistance in a collection of clinical (n = 121) and environmental isolates (n = 68) of A. flavus by the broth microdilution method. Six (5%) clinical isolates displayed voriconazole MIC greater than the epidemiological cutoff value. Two of these isolates with non-wild-type MIC were isolated from same patient and were genetically distinct, which was confirmed by amplified fragment length polymorphism analysis. Mutations associated with azole resistance were not present in the lanosterol 14-α demethylase coding genes (cyp51A, cyp51B, and cyp51C). Basal and voriconazole-induced expression of cyp51A homologs and various efflux pump genes was analyzed in three each of non-wild-type and wild-type isolates. All of the efflux pump genes screened showed low basal expression irrespective of the azole susceptibility of the isolate. However, the non-wild-type isolates demonstrated heterogeneous overexpression of many efflux pumps and the target enzyme coding genes in response to induction with voriconazole (1 μg/ml). The most distinctive observation was approximately 8- to 9-fold voriconazole-induced overexpression of an ortholog of the Candida albicans ATP binding cassette (ABC) multidrug efflux transporter, Cdr1, in two non-wild-type isolates compared to those in the reference strain A. flavus ATCC 204304 and other wild-type strains. Although the dominant marker of azole resistance in A. flavus is still elusive, the current study proposes the possible role of multidrug efflux pumps, especially that of Cdr1B overexpression, in contributing azole resistance in A. flavus.

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