scholarly journals Chromatinized Protein Kinase C-θ Directly Regulates Inducible Genes in Epithelial to Mesenchymal Transition and Breast Cancer Stem Cells

2014 ◽  
Vol 34 (16) ◽  
pp. 2961-2980 ◽  
Author(s):  
Anjum Zafar ◽  
Fan Wu ◽  
Kristine Hardy ◽  
Jasmine Li ◽  
Wen Juan Tu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Cancer Stem Cells ◽  
Epithelial To Mesenchymal Transition ◽  
Breast Cancer Stem Cells ◽  
Mesenchymal Transition ◽  
Kinase C ◽  
Inducible Genes

scholarly journals Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells

Cancer Cell ◽  
2013 ◽  
Vol 24 (3) ◽  
pp. 347-364 ◽  
Author(s):  
Wai Leong Tam ◽  
Haihui Lu ◽  
Joyce Buikhuisen ◽  
Boon Seng Soh ◽  
Elgene Lim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Cancer Stem Cells ◽  
Therapeutic Target ◽  
Breast Cancer Stem Cells ◽  
Kinase C

scholarly journals AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells

Oncogene ◽  
2013 ◽  
Vol 33 (10) ◽  
pp. 1316-1324 ◽  
Author(s):  
M K Asiedu ◽  
F D Beauchamp-Perez ◽  
J N Ingle ◽  
M D Behrens ◽  
D C Radisky ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Epithelial To Mesenchymal Transition ◽  
Breast Cancer Stem Cells ◽  
Mesenchymal Transition

scholarly journals Immune-Induced Epithelial to Mesenchymal Transition In vivo Generates Breast Cancer Stem Cells

2009 ◽  
Vol 69 (7) ◽  
pp. 2887-2895 ◽  
Author(s):  
Marta Santisteban ◽  
Jennifer M. Reiman ◽  
Michael K. Asiedu ◽  
Marshall D. Behrens ◽  
Aziza Nassar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Epithelial To Mesenchymal Transition ◽  
Breast Cancer Stem Cells ◽  
Mesenchymal Transition

scholarly journals Signaling pathways governing breast cancer stem cells behavior

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Kai Song ◽  
Maryam Farzaneh
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Signaling Pathways ◽  
Epithelial To Mesenchymal Transition ◽  
Critical Role ◽  
The Body ◽  
Breast Cancer Stem Cells ◽  
Self Renewal ◽  
Mesenchymal Transition

AbstractBreast cancer is the second common cancer and the leading cause of malignancy among females overall. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells that play a critical role in the metastasis of breast cancer to other organs in the body. BCSCs have both self-renewal and differentiation capacities, which are thought to contribute to the aggressiveness of metastatic lesions. Therefore, targeting BCSCs can be a suitable approach for the treatment and metastasis of breast cancer. Growing evidence has indicated that the Wnt, NFκB, Notch, BMP2, STAT3, and hedgehog (Hh) signaling pathways govern epithelial-to-mesenchymal transition (EMT) activation, growth, and tumorigenesis of BCSCs in the primary regions. miRNAs as the central regulatory molecules also play critical roles in BCSC self-renewal, metastasis, and drug resistance. Hence, targeting these pathways might be a novel therapeutic approach for breast cancer diagnosis and therapy. This review discusses known signaling mechanisms involved in the stimulation or prevention of BCSC self-renewal, metastasis, and tumorigenesis.

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