scholarly journals Canonical and Kinase Activity-Independent Mechanisms for Extracellular Signal-Regulated Kinase 5 (ERK5) Nuclear Translocation Require Dissociation of Hsp90 from the ERK5-Cdc37 Complex

2013 ◽  
Vol 33 (8) ◽  
pp. 1671-1686 ◽  
Author(s):  
T. Erazo ◽  
A. Moreno ◽  
G. Ruiz-Babot ◽  
A. Rodriguez-Asiain ◽  
N. A. Morrice ◽  
...  
Keyword(s):  
Kinase Activity ◽  
Nuclear Translocation ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

scholarly journals Multiregion Quantification of Extracellular Signal-regulated Kinase Activity in Renal Cell Carcinoma

2020 ◽  
Vol 3 (3) ◽  
pp. 360-364 ◽  
Author(s):  
Christian R. Hoerner ◽  
Rustin Massoudi ◽  
Thomas J. Metzner ◽  
Laurel Stell ◽  
Jennifer J. O’Rourke ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Kinase Activity ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

scholarly journals Periplaneta americana Extracts Promote Skin Wound Healing via Nuclear Factor Kappa B Canonical Pathway and Extracellular Signal-Regulated Kinase Signaling

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Qin Song ◽  
Qiheng Gou ◽  
Yuxin Xie ◽  
Zhen Zhang ◽  
Chaomei Fu
Keyword(s):  
Wound Healing ◽  
Molecular Mechanisms ◽  
Periplaneta Americana ◽  
Nuclear Factor Kappa B ◽  
Nuclear Translocation ◽  
Nuclear Factor ◽  
Protective Function ◽  
Extracellular Signal Regulated Kinase ◽  
Nuclear Factor Kappa ◽  
Extracellular Signal

Periplaneta americana extracts (PAEs) exhibit wound healing properties. However, the underlying molecular mechanisms are not well understood. Here, we treated human skin fibroblasts (HSF) with PAE and the proliferation was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The wound healing and transwell migration assays were used to detect cell migration. Nuclear factor kappa B (NF-κB) and extracellular signal-regulated kinase (ERK) pathways were analyzed by Western blot (WB). Immunofluorescence staining was used to detect the key molecular localization in the cells. The results showed that PAE enhanced the proliferation and migration of HSF cells. The expression and activation of key proteins such as RelA and p-ERK were increased in NF-κB and ERK pathways followed by nuclear translocation. In vivo, both WB and immunohistochemical (IHC) staining showed that PAE enhanced p-IκBα and p-ERK activation and the nuclear translocation of RelA. Our study suggests that the protective function of PAE is mediated via enhanced NF-κB and ERK signaling.

scholarly journals Feedforward regulation of mRNA stability by prolonged extracellular signal-regulated kinase activity

FEBS Journal ◽  
2015 ◽  
Vol 282 (4) ◽  
pp. 613-629 ◽  
Author(s):  
Takeshi Nagashima ◽  
Norihiko Inoue ◽  
Noriko Yumoto ◽  
Yuko Saeki ◽  
Shigeyuki Magi ◽  
...  
Keyword(s):  
Mrna Stability ◽  
Kinase Activity ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

scholarly journals Inhibition of extracellular signal-regulated kinase activity by sorafenib increases sensitivity to DNR in K562 cells

2013 ◽  
Vol 29 (5) ◽  
pp. 1895-1901 ◽  
Author(s):  
RUO-ZHI XIAO ◽  
CHENG-MING HE ◽  
MU-JUN XIONG ◽  
XING-XING RUAN ◽  
LI-LIN WANG ◽  
...  
Keyword(s):  
Kinase Activity ◽  
K562 Cells ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal
Sign in / Sign up

Export Citation Format

Share Document