scholarly journals ck2-Dependent Phosphorylation of Progesterone Receptors (PR) on Ser81 Regulates PR-B Isoform-Specific Target Gene Expression in Breast Cancer Cells

2011 ◽  
Vol 31 (12) ◽  
pp. 2439-2452 ◽  
Author(s):  
C. R. Hagan ◽  
T. M. Regan ◽  
G. E. Dressing ◽  
C. A. Lange
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Target Gene ◽  
Progesterone Receptors ◽  
Specific Target ◽  
Target Gene Expression ◽  
Specific Target Gene

scholarly journals Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells

2009 ◽  
Vol 37 (8) ◽  
pp. 2584-2595 ◽  
Author(s):  
Nalinie S. Wickramasinghe ◽  
Tissa T. Manavalan ◽  
Susan M. Dougherty ◽  
Krista A. Riggs ◽  
Yong Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Target Gene ◽  
Target Gene Expression ◽  
Mcf 7

scholarly journals The LIM protein Ajuba recruits DBC1 and CBP/p300 to acetylate ERα and enhances ERα target gene expression in breast cancer cells

2018 ◽  
Vol 47 (5) ◽  
pp. 2322-2335 ◽  
Author(s):  
Beihui Xu ◽  
Qi Li ◽  
Ning Chen ◽  
Chunxiao Zhu ◽  
Qingrong Meng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Target Gene ◽  
Lim Protein ◽  
Target Gene Expression

scholarly journals Doxorubicin Induces Apoptosis through down Regulation of miR-21 Expression and Increases miR-21 Target Gene Expression in MCF-7 Breast Cancer Cells

2017 ◽  
Vol 08 (06) ◽  
pp. 386-394
Author(s):  
Roghayeh Tofigh ◽  
Saeedeh Akhavan ◽  
Nastaran Tarban ◽  
Amin Ebrahimi Sadrabadi ◽  
Arsalan Jalili ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Target Gene ◽  
Down Regulation ◽  
Target Gene Expression ◽  
Mcf 7

Ligand-inducible and liver-specific target gene expression in transgenic mice

1997 ◽  
Vol 15 (3) ◽  
pp. 239-243 ◽  
Author(s):  
Yaolin Wang ◽  
Franco J. DeMayo ◽  
Sophia Y. Tsai ◽  
Bert W. O'Malley
Keyword(s):  
Gene Expression ◽  
Transgenic Mice ◽  
Target Gene ◽  
Specific Target ◽  
Target Gene Expression ◽  
Specific Target Gene

scholarly journals Identification of novel oestrogen receptor target genes in human ZR75-1 breast cancer cells by expression profiling

2001 ◽  
Vol 27 (3) ◽  
pp. 259-274 ◽  
Author(s):  
M Soulez ◽  
MG Parker
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cytochrome P450 ◽  
Amino Acid ◽  
Growth Factor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Target Gene ◽  
Cationic Amino Acid Transporter ◽  
Cationic Amino Acid

Oligonucleotide microarrays were used to analyse gene expression profiles in human ZR75-1 breast cancer cells in the presence of 17beta-oestradiol and oestrogen antagonists. Differential gene expression of a number of genes was confirmed by quantitative RNA analysis. In addition to known oestrogen-responsive genes, an appreciable number of novel targets were identified, including growth factors and components of the cell cycle, adhesion molecules, enzymes, signalling molecules and transcription factors. The most pronounced oestrogen-sensitive gene was that for the cytochrome P450-IIB enzyme, involved in metabolising steroids and xenobiotics, which was increased 100-fold over a 24 h period. It is a direct target gene for oestrogens, because its expression was increased in the presence of cyclohexamide. In contrast, expression of cytochrome P450-IIB was not detected in human MCF7 breast cancer cells. Expressions of the cationic amino acid transporter E16, gap junction protein and insulin-like growth factor binding protein 4 were also markedly increased by oestrogens, but the kinetics of induction varied according to the target gene. With the exception of the cationic amino acid transporter E16 and the insulin-like growth factor binding protein 4, the expression of the majority of the genes was unaffected by antioestrogen treatment. Further analysis of this set of markers will provide alternative approaches to the investigation of the mitogenicity of oestrogens in breast cancer cells.

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