scholarly journals Establishment and Use of Epidemiological Cutoff Values for Molds and Yeasts by Use of the Clinical and Laboratory Standards Institute M57 Standard

2017 ◽  
Vol 55 (5) ◽  
pp. 1262-1268 ◽  
Author(s):  
Shawn R. Lockhart ◽  
Mahmoud A. Ghannoum ◽  
Barbara D. Alexander
Keyword(s):  
Clinical Practice ◽  
Clinical Outcome ◽  
Antifungal Agent ◽  
Outcome Data ◽  
Fungal Isolate ◽  
Wild Type ◽  
Clinical Outcome Data ◽  
Cutoff Values

ABSTRACT Breakpoints are used to predict whether an antifungal agent will be clinically effective against a particular fungal isolate. They are based on a combination of MIC values, pharmacokinetic/pharmacodynamic values, and clinical outcome data. For many fungus-antifungal combinations, these data might never be available. For these combinations, epidemiological cutoff values (ECVs) provide a methodology for categorizing isolates as either wild type (WT) or non-WT. In this review, we define ECVs, explain how they are generated using the CLSI methodology in standard M57, and describe how they can be used in clinical practice.

North American Solitaire Stent Retriever Acute Stroke registry: post-marketing revascularization and clinical outcome results

2018 ◽  
Vol 10 (Suppl 1) ◽  
pp. i45-i49 ◽  
Author(s):  
Osama O Zaidat ◽  
Alicia C Castonguay ◽  
Rishi Gupta ◽  
Chung-Huan J Sun ◽  
Coleman Martin ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Clinical Practice ◽  
Clinical Outcome ◽  
Acute Stroke ◽  
Acute Ischemic Stroke ◽  
North American ◽  
Outcome Data ◽  
Stent Retriever ◽  
Post Marketing ◽  
Solitaire Fr

BackgroundLimited post-marketing data exist on the use of the Solitaire FR device in clinical practice. The North American Solitaire Stent Retriever Acute Stroke (NASA) registry aimed to assess the real world performance of the Solitaire FR device in contrast with the results from the SWIFT (Solitaire with the Intention for Thrombectomy) and TREVO 2 (Trevo versus Merci retrievers for thrombectomy revascularization of large vessel occlusions in acute ischemic stroke) trials.MethodsThe investigator initiated NASA registry recruited North American sites to submit retrospective angiographic and clinical outcome data on consecutive acute ischemic stroke (AIS) patients treated with the Solitaire FR between March 2012 and February 2013. The primary outcome was a Thrombolysis in Myocardial Ischemia (TIMI) score of ≥2 or a Treatment in Cerebral Infarction (TICI) score of ≥2a. Secondary outcomes were 90 day modified Rankin Scale (mRS) score, mortality, and symptomatic intracranial hemorrhage.Results354 patients underwent treatment for AIS using the Solitaire FR device in 24 centers. Mean time from onset to groin puncture was 363.4±239 min, mean fluoroscopy time was 32.9±25.7 min, and mean procedure time was 100.9±57.8 min. Recanalization outcome: TIMI ≥2 rate of 83.3% (315/354) and TICI ≥2a rate of 87.5% (310/354) compared with the operator reported TIMI ≥2 rate of 83% in SWIFT and TICI ≥2a rate of 85% in TREVO 2. Clinical outcome: 42% (132/315) of NASA patients demonstrated a 90 day mRS ≤2 compared with 37% (SWIFT) and 40% (TREVO 2). 90 day mortality was 30.2% (95/315) versus 17.2% (SWIFT) and 29% (TREVO 2).ConclusionsThe NASA registry demonstrated that the Solitaire FR device performance in clinical practice is comparable with the SWIFT and TREVO 2 trial results.

Increasing engagement with clinical outcome data

2011 ◽  
Vol 17 (12) ◽  
pp. 585-589
Author(s):  
Riaz Dharamshi ◽  
Toby Hillman ◽  
Rory Shaw
Keyword(s):  
Clinical Outcome ◽  
Outcome Data ◽  
Clinical Outcome Data

scholarly journals Multicenter Study of Method-Dependent Epidemiological Cutoff Values for Detection of Resistance in Candida spp. and Aspergillus spp. to Amphotericin B and Echinocandins for the Etest Agar Diffusion Method

2016 ◽  
Vol 61 (1) ◽  
Author(s):  
A. Espinel-Ingroff ◽  
M. Arendrup ◽  
E. Cantón ◽  
S. Cordoba ◽  
E. Dannaoui ◽  
...  
Keyword(s):  
Amphotericin B ◽  
Susceptibility Testing ◽  
The United States ◽  
Fungal Isolate ◽  
Diffusion Method ◽  
Wild Type ◽  
Candida Spp ◽  
Content Type ◽  
Phenotypic Resistance ◽  
Cutoff Values

ABSTRACTMethod-dependent Etest epidemiological cutoff values (ECVs) are not available for susceptibility testing of eitherCandidaorAspergillusspecies with amphotericin B or echinocandins. In addition, reference caspofungin MICs forCandidaspp. are unreliable.CandidaandAspergillusspecies wild-type (WT) Etest MIC distributions (microorganisms in a species-drug combination with no detectable phenotypic resistance) were established for 4,341Candida albicans, 113C. dubliniensis, 1,683C. glabrataspecies complex (SC), 709C. krusei, 767C. parapsilosisSC, 796C. tropicalis, 1,637Aspergillus fumigatusSC, 238A. flavusSC, 321A. nigerSC, and 247A. terreusSC isolates. Etest MICs from 15 laboratories (in Argentina, Europe, Mexico, South Africa, and the United States) were pooled to establish Etest ECVs. Anidulafungin, caspofungin, micafungin, and amphotericin B ECVs (in micrograms per milliliter) encompassing ≥97.5% of the statistically modeled population were 0.016, 0.5, 0.03, and 1 forC. albicans; 0.03, 1, 0.03, and 2 forC. glabrataSC; 0.06, 1, 0.25, and 4 forC. krusei; 8, 4, 2, and 2 forC. parapsilosisSC; and 0.03, 1, 0.12, and 2 forC. tropicalis. The amphotericin B ECV was 0.25 μg/ml forC. dubliniensisand 2, 8, 2, and 16 μg/ml for the complexes ofA. fumigatus,A. flavus,A. niger, andA. terreus, respectively. While anidulafungin Etest ECVs classified 92% of theCandida fksmutants evaluated as non-WT, the performance was lower for caspofungin (75%) and micafungin (84%) cutoffs. Finally, although anidulafungin (as an echinocandin surrogate susceptibility marker) and amphotericin B ECVs should identifyCandidaandAspergillusisolates with reduced susceptibility to these agents using the Etest, these ECVs will not categorize a fungal isolate as susceptible or resistant, as breakpoints do.

scholarly journals Association between duration of untreated bipolar disorder and clinical outcome: data from a Brazilian sample

2016 ◽  
Vol 38 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Gustavo C. Medeiros ◽  
Sofia B. Senço ◽  
Beny Lafer ◽  
Karla M. Almeida
Keyword(s):  
Bipolar Disorder ◽  
Clinical Outcome ◽  
Outcome Data ◽  
Brazilian Sample ◽  
Clinical Outcome Data

scholarly journals Thrombolytic-Related Asymptomatic Hemorrhagic Transformation Does Not Deteriorate Clinical Outcome: Data from TIMS in China

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142381 ◽  
Author(s):  
Weihua Jia ◽  
Xiaoling Liao ◽  
Yuesong Pan ◽  
Yilong Wang ◽  
Tao Cui ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Hemorrhagic Transformation ◽  
Outcome Data ◽  
Clinical Outcome Data

WE-D-T-6E-07: Incorporating Clinical Outcome Data Into IMRT Inverse Planning

2005 ◽  
Vol 32 (6Part19) ◽  
pp. 2140-2140
Author(s):  
L Xing ◽  
Y Yang ◽  
B Widrow
Keyword(s):  
Clinical Outcome ◽  
Outcome Data ◽  
Inverse Planning ◽  
Clinical Outcome Data
Sign in / Sign up

Export Citation Format

Share Document