scholarly journals Rapid Diagnosis of Vivax Malaria by the SD Bioline Malaria Antigen Test When Thrombocytopenia Is Present

2007 ◽  
Vol 46 (3) ◽  
pp. 939-942 ◽  
Author(s):  
S. W. Lee ◽  
K. Jeon ◽  
B. R. Jeon ◽  
I. Park
Keyword(s):  
Vivax Malaria ◽  
Rapid Diagnosis ◽  
Antigen Test ◽  
Malaria Antigen

scholarly journals Rapid Diagnosis of Malaria by Antigen Detection

2009 ◽  
Vol 3 (1) ◽  
pp. 14-16
Author(s):  
Mesbah Uddin Ahmed ◽  
Md Akram Hossain ◽  
AKM Shamsuzzaman ◽  
Md Murshed Alam ◽  
Abdul Hossain Khan ◽  
...  
Keyword(s):  
Thin Films ◽  
Sensitivity And Specificity ◽  
Standard Method ◽  
Gold Standard ◽  
Rapid Diagnosis ◽  
Healthy Controls ◽  
Immunochromatographic Test ◽  
Gold Standard Method ◽  
Malaria Antigen ◽  
Age And Sex

The study was conducted to evaluate the sensitivity and specificity of Immunochromatographic test (ICT) for antigen, using microscopy as the "gold standard" method for diagnosis of malaria. A total of 98 clinically suspected malaria patients and another 30 age and sex-matched healthy controls were included in this study. Thick and thin films were also prepared and examined under microscope as well as Immunochromatographic test (ICT) was performed for malaria antigen. Sensitivity and specificity of ICT for antigen were 93.22% and 94.87% respectively. Keywords: Detection of malaria antigen, Immunochromatographic test   doi: 10.3329/bjmm.v3i1.2965 Bangladesh J Med Microbiol 2009; 03 (01): 14-16

scholarly journals Comparative Sensitivity of Rapid Antigen Tests for the Delta Variant (B.1.617.2) of SARS-CoV-2

Viruses ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2183
Author(s):  
Yuko Sakai-Tagawa ◽  
Seiya Yamayoshi ◽  
Peter J. Halfmann ◽  
Yoshihiro Kawaoka
Keyword(s):  
Rapid Detection ◽  
Influenza A ◽  
Infectious Virus ◽  
Rapid Test ◽  
Rapid Diagnosis ◽  
Antigen Test ◽  
Detection Level ◽  
Test Kit ◽  
Low Levels ◽  
Antigen Tests

Rapid antigen tests (RATs) for COVID-19 based on lateral flow immunoassays are useful for rapid diagnosis in a variety of settings. Although many kinds of RATs are available, their respective sensitivity has not been compared. Here, we examined the sensitivity of 27 RATs available in Japan for the detection of the SARS-CoV-2 delta variant. All of the RATs tested detected the delta variant albeit with different sensitivities. Nine RATs (ESPLINE SARS-CoV-2, ALSONIC COVID-19 Ag, COVID-19 and Influenza A+B Antigen Combo Rapid Test, ImmunoArrow SARS-CoV-2, Fuji Dri-chem immuno AG cartridge COVID-19 Ag, 2019-nCoV Ag rapid detection kit, Saliva SARS-CoV-2(2019-nCoV) Antigen Test Kit, and Rabliss SARS-CoV-2 antigen detection kit COVID19 AG) showed superior sensitivity to the isolated delta variant. Although actual clinical specimens were not examined, the detection level of most of the RATs was 7500 pfu, indicating that individuals whose test samples contained less virus than that would be considered negative. Therefore, it is important to bear in mind that RATs may miss individuals shedding low levels of infectious virus.

scholarly journals Abnormal WBC Scattergrams by Sysmex XN550, A Supplementary Diagnostic Tool for Malaria to the Conventional Methods

2021 ◽  
Vol 8 (1) ◽  
pp. A14-19
Author(s):  
Rajeshwar Suresh Bute ◽  
Bhavana Madhukar Bharambe ◽  
Ravikiran Pawar ◽  
Asawari Bharat Jadhav
Keyword(s):  
Cost Effective ◽  
Rapid Diagnostic Tests ◽  
Gray Zone ◽  
Antigen Test ◽  
Peripheral Smear ◽  
Parasite Detection ◽  
Malaria Antigen ◽  
A Prospective Study ◽  
Thick Smear ◽  
Ethical Clearance

Background: In India, malaria has a major impact on health system. It is usually diagnosed based on symptomatology, parasite detection in the peripheral smear (PS) or rapid diagnostic tests (RDT) such as malaria antigen test (MAT). Detection of malaria by MAT is considered as the gold standard. A rapid, cost effective screening of malaria can be done with the automated analyzers. The present study was undertaken to assess the efficacy of WBC scattergram generated by Sysmex XN 550 hematology analyzer to diagnose malaria. Methods: A prospective study was conducted over a period of 4 months from August to November 2019, after obtaining institutional ethical clearance. All cases diagnosed as Plasmodium vivax / Plasmodium falciparum infections on malaria antigen test (MAT) were included. Their hemogram and WBC scattergrams obtained from Sysmex XN 550 were studied. Thick & thin Smears were made and stained with Leishman’s stain for microscopy. Results: A total of 101 cases were diagnosed as malaria positive by MAT and thick smear. Ninety-seven were positive by Leishman’s stain. Abnormal scattergrams were 81 out of 101 malaria positive cases. The commonest pattern was double neutrophil zone (n=22) followed by double neutrophil with less space between neutrophil and eosinophil (n=17). An abnormal event on X axis was observed in 16 patients. Gray zone and double eosinophil areas were observed in 11 and 4 cases respectively. The sensitivity of the analyzer was found to be 80.19%. Conclusion: Scattergram of automated haematology analyser (Sysmex XN 550) has good sensitivity, which can be increased to a better level if combined with thrombocytopenia and symptomatology of the patients.

scholarly journals The Brief Case: False-Positive Rapid Malaria Antigen Test Result in a Returned Traveler

2017 ◽  
Vol 55 (8) ◽  
pp. 2294-2297 ◽  
Author(s):  
Kristle L. Haberichter ◽  
Paul C. Johnson ◽  
Paul J. Chittick ◽  
Peter Millward ◽  
Barbara Robinson-Dunn ◽  
...  
Keyword(s):  
False Positive ◽  
Antigen Test ◽  
Malaria Antigen ◽  
Test Result

scholarly journals The BinaxNOW pneumococcal antigen test: An adjunct for diagnosis of pneumococcal bacteraemia

2021 ◽  
Vol 36 (1) ◽  
Author(s):  
Hafsah D. Tootla ◽  
Colleen Bamford ◽  
Chad M. Centner ◽  
Clinton Moodley
Keyword(s):  
Streptococcus Pneumoniae ◽  
Respiratory Illness ◽  
Cross Reactivity ◽  
Rapid Diagnosis ◽  
Culture Broth ◽  
Antigen Test ◽  
Gram Stain ◽  
Gram Positive ◽  
Predictive Values ◽  
Gram Positive Cocci

Background: Culture remains the diagnostic standard for Streptococcus pneumoniae bacteraemia but is limited by time to identification, prior antibiotics and bacterial autolysis. Culture-independent methods for detecting S. pneumoniae include PCR and antigen tests. We evaluated an antigen test on blood culture broth for the rapid detection of S. pneumoniae bacteraemia.Method: We collected 212 signal-positive blood cultures, with gram-positive cocci in pairs, chains or with uncertain morphology. The BinaxNOW S. pneumoniae urinary antigen test, Gram stain, culture and lytA PCR were performed on all samples. Diagnostic accuracy of the antigen test and Gram stain with gram-positive cocci in pairs were compared with culture, polymerase chain reaction (PCR) and the composite of culture and PCR.Results: Streptococcus pneumoniae was isolated in 26% of samples, 66% cultured other gram-positive organisms and 8% of samples had no growth. Sensitivity and negative predictive values of the antigen test were 100%, specificity and positive predictive values were 87% – 88% and 76% – 81%, but increased to 93% – 96% and 96% – 98% when applied to subsets with gram-positive cocci in pairs, or history compatible with respiratory illness or meningitis. Sensitivity (69% – 75%) and specificity (81%) of Gram stain (gram-positive cocci in pairs) were lower than the antigen test even when applied to the same subsets.Conclusion: Accurate and rapid diagnosis of S. pneumoniae bacteraemia is challenging. Specificity of this antigen test is limited by cross-reactivity with other gram-positive organisms, but could be improved if Gram stain morphology and clinical history are available. The antigen test is a useful adjunct for rapid diagnosis of S. pneumoniae bacteraemia.

scholarly journals Closing the Brief Case: False-Positive Rapid Malaria Antigen Test Result in a Returned Traveler

2017 ◽  
Vol 55 (8) ◽  
pp. 2560-2561
Author(s):  
Kristle L. Haberichter ◽  
Paul C. Johnson ◽  
Paul J. Chittick ◽  
Peter Millward ◽  
Barbara Robinson-Dunn ◽  
...  
Keyword(s):  
False Positive ◽  
Antigen Test ◽  
Malaria Antigen ◽  
Test Result

scholarly journals AUTOMATED HEMATOLOGY ANALYZERS IN DIAGNOSIS OF PLASMODIUM VIVAX MALARIA: AN ADJUNCT TO CONVENTIONAL MICROSCOPY.

2014 ◽  
Vol 6 (1) ◽  
pp. e2014034
Author(s):  
Kolakkadan Mubeen Hasaf ◽  
Wilfred Clement Devadoss ◽  
Rau Rangan Aarathi ◽  
Monnappa Gitanjali ◽  
Shetty Prasanna ◽  
...  
Keyword(s):  
Positive Predictive Value ◽  
Predictive Value ◽  
Vivax Malaria ◽  
High Sensitivity ◽  
Rapid Diagnosis ◽  
Parasitic Diseases ◽  
Presumptive Diagnosis ◽  
Plasmodium Vivax Malaria ◽  
Conventional Microscopy ◽  
Hematology Analyzers

Malaria is one of the most pervasive parasitic diseases ever known to mankind affecting nearly 300 million people every year. The need for rapid diagnosis of malaria in tropical and subtropical malaria endemic areas is on the rise. In this study we evaluated the usefulness of hematology autoanalyzers, Sysmex XE-2100 & XT-2000i in the presumptive diagnosis of malaria. Our study shows that abnormalities in WBC/BASO scattergram when combined with presence of thrombocytopenia had a high sensitivity and positive predictive value in the presumptive diagnosis of malaria.

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