scholarly journals Plasmodium P25 and P28 Surface Proteins: Potential Transmission-Blocking Vaccines

2007 ◽  
Vol 6 (8) ◽  
pp. 1260-1265 ◽  
Author(s):  
Ajay K. Saxena ◽  
Yimin Wu ◽  
David N. Garboczi
Keyword(s):  
Surface Proteins ◽  
Transmission Blocking ◽  
Transmission Blocking Vaccines

Proteins of the malaria parasite sexual stages: expression, function and potential for transmission blocking strategies

Parasitology ◽  
2007 ◽  
Vol 134 (14) ◽  
pp. 1911-1929 ◽  
Author(s):  
G. PRADEL
Keyword(s):  
Expression Patterns ◽  
Surface Proteins ◽  
Sexual Stage ◽  
Transmission Blocking ◽  
Antigenic Properties ◽  
Stage Development ◽  
Sexual Stages ◽  
Regulatory Functions ◽  
Gene Information ◽  
Transmission Blocking Vaccines

SUMMARYThe sexual phase of the malaria pathogen,Plasmodium falciparum, culminates in fertilization within the midgut of the mosquito and represents a crucial step in the completion of the parasite's life-cycle and transmission of the disease. Two decades ago, the first sexual stage-specific surface proteins were identified, among themPfs230,Pfs48/45, andPfs25, which were of scientific interest as candidates for the development of transmission blocking vaccines. A decade later, gene information gained from the sequencing of theP. falciparumgenome led to the identification of numerous additional sexual-stage proteins with antigenic properties and novel enzymes that putatively possess regulatory functions during sexual-stage development. This review aims to summarize the sexual-stage proteins identified to date, to compare their stage specificities and expression patterns and to highlight novel regulative mechanisms of sexual differentiation. The prospective candidacy of select sexual-stage proteins as targets for transmission blocking strategies will be discussed.

Malaria transmission-blocking vaccines: wheat germ cell-free technology can accelerate vaccine development

2019 ◽  
Vol 18 (10) ◽  
pp. 1017-1027
Author(s):  
Kazutoyo Miura ◽  
Mayumi Tachibana ◽  
Eizo Takashima ◽  
Masayuki Morita ◽  
Bernard N. Kanoi ◽  
...  
Keyword(s):  
Germ Cell ◽  
Malaria Transmission ◽  
Wheat Germ ◽  
Vaccine Development ◽  
Transmission Blocking ◽  
Transmission Blocking Vaccines

scholarly journals The P25 Ookinete Surface Proteins: Homology Modeling and Phylogenetic Relationships

2013 ◽  
Vol 2013 ◽  
pp. 1-17
Author(s):  
Babita Sharma ◽  
Manoj Kumar Jaiswal
Keyword(s):  
Phylogenetic Relationships ◽  
Surface Protein ◽  
Surface Proteins ◽  
Parasite Development ◽  
Transmission Blocking ◽  
Malaria Burden ◽  
Mosquito Midgut ◽  
Egf Domain ◽  
Domain Iii

Sexual stages of Plasmodium such as zygote, ookinete, and young oocysts express 25 kDa surface protein P25, which along with P28 proteins protect the parasite from harmful environment inside mosquito midgut. Vaccines against these proteins induce antibodies in vertebrate host capable to inhibit parasite development in mosquito midgut and thus preventing the transmission of parasite from mosquito to other human host. Transmission-blocking vaccines help reduce malaria burden. The purpose of this study was in silico structural characterization of P25 family proteins and to predict their phylogenetic relationships with other proteins. Results indicate that members of P25 family have four EGF domains arranged in triangular fashion with major variations lying in the loop regions. All 22 cysteines are conserved forming 11 disulphide bonds. The C-loop of EGF domain IV in P25 proteins is smaller in comparison to P28 proteins. B loop of EGF domain II showed maximum RMSD variations followed by loops of EGF domain III. P25 proteins are tile-like triangular flat proteins that protect the parasite inside mosquito midgut. Obtained structures will help in understanding the biology of the parasite inside the mosquito midgut. These structures may also help in designing transmission-blocking vaccine against malaria in absence of experimentally determined structures.

scholarly journals Transmission-Blocking Preventive Measures for Infectious Diseases: Altruism, Solidarity, and the Common Good

2021 ◽  
Author(s):  
Laine Garber ◽  
Joseph M. Vinetz
Keyword(s):  
Public Health ◽  
Common Good ◽  
Preventive Measures ◽  
Public Attention ◽  
Transmission Blocking ◽  
Contagious Diseases ◽  
Central Tenet ◽  
Health Advice ◽  
The Common ◽  
Transmission Blocking Vaccines

Aiming to prevent the spread of contagious diseases has long been a central tenet of public health. In the present time, divisive political responses to mask wearing to prevent SARS-CoV-2 transmission have competed with sound public health advice for public attention. Here, we draw parallels in terms of individualism versus societal solidarity between the slow and ponderous development of transmission-blocking vaccines for malaria and advocacy for mask wearing to prevent COVID-19.

scholarly journals Management strategies in a malaria model combining human and transmission-blocking vaccines

2017 ◽  
Vol 22 (3) ◽  
pp. 977-1000 ◽  
Author(s):  
Jemal Mohammed-Awel ◽  
◽  
Ruijun Zhao ◽  
Eric Numfor ◽  
Suzanne Lenhart ◽  
...  
Keyword(s):  
Management Strategies ◽  
Transmission Blocking ◽  
Model Combining ◽  
Malaria Model ◽  
Transmission Blocking Vaccines
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