scholarly journals The dengue viruses.

1990 ◽  
Vol 3 (4) ◽  
pp. 376-396 ◽  
Author(s):  
E A Henchal ◽  
J R Putnak
Keyword(s):  
Dengue Virus ◽  
Hypovolemic Shock ◽  
Public Health Problem ◽  
Febrile Illness ◽  
The Body ◽  
Major Public Health Problem ◽  
Nonstructural Proteins ◽  
Tropical Regions ◽  
Acute Infectious Disease ◽  
Headache Pain

Dengue, a major public health problem throughout subtropical and tropical regions, is an acute infectious disease characterized by biphasic fever, headache, pain in various parts of the body, prostration, rash, lymphadenopathy, and leukopenia. In more severe or complicated dengue, patients present with a severe febrile illness characterized by abnormalities of hemostasis and increased vascular permeability, which in some instances results in a hypovolemic shock. Four distinct serotypes of the dengue virus (dengue-1, dengue-2, dengue-3, and dengue-4) exist, with numerous virus strains found worldwide. Molecular cloning methods have led to a greater understanding of the structure of the RNA genome and definition of virus-specific structural and nonstructural proteins. Progress towards producing safe, effective dengue virus vaccines, a goal for over 45 years, has been made.

scholarly journals Searching for the dengue virus Achilles heel

2010 ◽  
Vol 31 (2) ◽  
pp. 64
Author(s):  
Paul Young
Keyword(s):  
Dengue Virus ◽  
Hypovolemic Shock ◽  
Public Health Problem ◽  
Febrile Illness ◽  
Dengue Shock Syndrome ◽  
Major Public Health Problem ◽  
Mosquito Vector ◽  
Territorial Expansion ◽  
Antiviral Therapies ◽  
The Tropics

Dengue viruses are a major public health problem throughout the tropical world, with up to 100 million people infected annually. Infection can result in acute febrile illness (dengue fever) and in severe cases is associated with abnormalities in vascular permeability and haemostasis (dengue haemorrhagic fever) that can lead to sudden and fatal hypovolemic shock (dengue shock syndrome). The incidence of dengue has steadily increased over the last two to three decades such that it is now endemic throughout much of the tropics and is the leading cause of infant mortality in some South-East Asian countries. Australia has not escaped this territorial expansion of dengue, with regular epidemic outbreaks now occurring in North Queensland. The epidemic that lasted for most of the summer of 2008?2009 involved the circulation of all four dengue virus serotypes and more than 1,000 confirmed cases. Coupled with the potential impact that climate change may have in increasing the range of its mosquito vector, there is growing concern that dengue may become endemic in Australia. Considerable challenges have accompanied the development of vaccine strategies for dengue and this has reinforced the importance of the complementary development of antiviral therapies. Part of our dengue research efforts has been focused on identifying viral targets for inhibitor design.

scholarly journals Usefulness of serum albumin as a prognostic factor in dengue

2020 ◽  
Vol 7 (3) ◽  
pp. 622
Author(s):  
Murali B. H. ◽  
Shilpa Deborah Lysander ◽  
Meghana Nannapaneni
Keyword(s):  
Public Health ◽  
Prognostic Factor ◽  
Serum Albumin ◽  
Hypovolemic Shock ◽  
Public Health Problem ◽  
Febrile Illness ◽  
Major Public Health Problem ◽  
Exclusion Criteria ◽  
Tropical Regions ◽  
Group 3

Background: Dengue is a major public health problem throughout subtropical and tropical regions. In more severe or complicated dengue, patients present with a severe febrile illness characterized by abnormalities of hemostasis and increased vascular permeability, which in some instances results in a hypovolemic shock. Dengue is endemic in more than 100 countries in tropical and subtropical regions with an estimated 390 million infections occurring worldwide, among which 96 million infections are clinically apparent. The objective of this study is to assess the usefulness of serum albumin as a prognostic factor in dengue.Method: This observational study enrolled 100 patients who were admitted in KIMS Hospital from June 2017 to June 2018 without any co morbidities as mentioned in the exclusion criteria. On day 4 of illness hemoglobin, packed cell volume, platelet and serum albumin were done, and the participants were classified into 3 groups based on clinical manifestationResults: In this study, hemoglobin was elevated on day 4 in group 3 when compared to other groups and it was statistically significant. Hemoconcentration and low platelet values were also seen in group 3 when compared to other groups showing statistical significance.Serum albumin was also low in group 3 when compared to other groups, which was strongly significant.Conclusion: Hence serum albumin can be used as a prognostic factor in dengue.

Knowledge, Awareness and Perception on Malaria in Tribal Regions of Vadodara District, Gujarat (India)

2019 ◽  
Vol 21 (3) ◽  
pp. 406-416
Author(s):  
Bindu Bhatt ◽  
Janak P. Joshi
Keyword(s):  
Malaria Control ◽  
Control Measure ◽  
Health Sector ◽  
Public Health Problem ◽  
Signs And Symptoms ◽  
Well Being ◽  
Clear Understanding ◽  
Major Public Health Problem ◽  
Health Seeking ◽  
Tropical Regions

Malaria affects health and general well-being of many people in the developing world. In India also, malaria is a major public health problem. It continues to be a leading cause of morbidity and mortality in many tropical regions of the world, despite global efforts to eradicate the disease. To achieve the targets of reducing malaria prevalence and preventing malaria epidemic, it is essential to have active community participation. Therefore, clear understanding of the Knowledge, Awareness and Perception (KAPs) of a particular community can help in framing the policy of prevention and promotion of any malaria control measure. In this context, the decision makers in the health sector are recognizing the importance of community’s KAPs on malaria and, thus, is gaining stimulus as one of the methods for malaria control. KAPs, however, play an important role in the improvement of health and health-seeking behaviour of a disease-burdened group. This study, therefore, investigates a local community’s KAPs on malaria in tribal areas of Vadodara District. The KAP investigates the community’s understanding of malaria transmission, their recognition of signs and symptoms, their treatment-seeking behaviours and community preventive measures and practices.

scholarly journals Clinical and epidemiologic characteristics associated with dengue fever in 2011–2016 in Bang Phae district, Ratchaburi province, Thailand

2021 ◽  
Vol 15 (6) ◽  
pp. e0009513
Author(s):  
Jacqueline Kyungah Lim ◽  
Pornthep Chanthavanich ◽  
Kriengsak Limkittikul ◽  
Jung-Seok Lee ◽  
Chukiat Sirivichayakul ◽  
...  
Keyword(s):  
Secondary Infection ◽  
Implementation Strategies ◽  
Public Health Problem ◽  
Febrile Illness ◽  
Major Public Health Problem ◽  
Mild Disease ◽  
Study Results ◽  
Dengue Prevention ◽  
Febrile Episodes ◽  
And Control

Background Dengue is a major public health problem in Thailand, but data are often focused on certain dengue-endemic areas. Methods: To better understand dengue epidemiology and clinical characteristics in Thailand, a fever surveillance study was conducted among patients aged 1–55 years, who presented with non-localized febrile illness at Bang Phae Community Hospital in Ratchaburi province, Thailand from October 2011 to September 2016. Results Among 951 febrile episodes, 130 were dengue-confirmed. Individuals aged 10–14 years were mostly affected, followed by those 15–19 years-of-age, with about 15% of dengue-confirmed cases from adults 25 years and older. There were annual peaks of dengue occurrence between June-November. Most prevalent serotype in circulation was DENV-2 in 2012, DENV-3 in 2014, and DENV-4 & -3 in 2015. Among dengue cases, 65% were accurately detected using the dengue NS1 RDT. Detection rate was similar between secondary and primary dengue cases where 66% of secondary vs. 60% of primary dengue cases had positive results on the NS1 RDT. Among dengue cases, 66% were clinically diagnosed with suspected dengue or DHF, prior to lab confirmation. Dengue was positively associated with rash, headache, hematemesis and alterations to consciousness, when compared to non-dengue. Dengue patients were 10.6 times more likely to be hospitalized, compared to non-dengue cases. Among dengue cases, 95 were secondary and 35 were primary infections. There were 8 suspected DHF cases and all were identified to be secondary dengue. Secondary dengue cases were 3.5 times more likely to be hospitalized compared to primary dengue cases. Although the majority of our dengue-positive patients were secondary dengue cases, with few patients showing manifestations of DHF, our dengue cases were mostly mild disease. Even among children < 10 years-of-age, 61% had secondary infection and the rate of secondary infection increased with age. Conclusion While the majority of dengue-confirmed cases were children, almost three-quarters of dengue-confirmed cases in this study were secondary dengue. Our study results consistent with previous data from the country confirm the hyperendemic transmission of DENV in Thailand, even in the non-epidemic years. With various interventions becoming available for dengue prevention and control, including dengue vaccines, decision-making on future implementation strategies should be based on such burden of disease data.

scholarly journals GAMBARAN NILAI HEMATOKRIT DAN LAJU ENDAP DARAH PADA ANAK DENGAN INFEKSI VIRUS DENGUE DI MANADO

2015 ◽  
Vol 3 (3) ◽  
Author(s):  
Sitti S. P. Kamuh ◽  
Arthur E. Mongan ◽  
Maya F. Memah
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Dengue Virus Infection ◽  
Erythrocyte Sedimentation

Abstract: Dengue is a major public health problem that can be found throughout the tropical and subtropical countries around the world. Spectrum of clinical manifestations of dengue virus infection varies greatly. In addition to clinical symptoms, the diagnosis of dengue virus infection need to be supported by blood tests such as hematocrit and erythrocyte sedimentation rate. This study aimed to determine the hematocrit value and erythrocyte sedimentation rate (ESR) in children with dengue virus infection in Manado. This study used a cross-sectional design and was conducted from Desember 2014 to January 2015 at GMIM Pancaran Kasih, Advent, and Robert Wolter Mongisidi hospitals in Manado. There were 37 patients that fulfilled the inclusion criteria, consisted of 17 males and 20 females. The results showed that of 37 patients, there were 36 with hematocrit within normal limits. Moreover, of 37 patients only 6 patients performed the ESR examination; only 1 child had a rapid ESR result (> 15mm/h). Conclusion: In this study, most of the pediatric patients with dengue virus infection in Manado had normal hematocrit. Of 6 patients who had performed ESR test, only 1 had rapid ESR.Keywords: dengue, hematocrit, erythrocyte sedimentation rateAbstrak: Dengue merupakan masalah kesehatan masyarakat yang utama dan dapat ditemui diseluruh daerah tropis dan subtropis di seluruh dunia. Spektrum manifestasi klinis infeksi virus dengue sangat bervariasi. Selain gejala klinis, diagnosis infeksi virus dengue perlu ditunjang hasil uji darah di laboratorium antara lain hematokrit dan laju endap darah (LED). Penelitian ini bertujuan untuk mengetahui nilai hematokrit dan LED pada anak dengan infeksi virus dengue di Manado. Penelitian ini menggunakan desain potong lintang, dilakukan pada bulan Desember 2014 sampai Januari 2015 di RSU GMIM Pancaran Kasih Manado, RS Advent Manado, dan RSAD Robert Wolter Mongisidi Teling17 anak laki-laki dan 20 anak perempuan. Hasil penelitian memperlihatkan 36 dari 37 pasien mempunyai hematokrit normal. Dasri 37 pasien, hanya 6 anak yang menjalani pemeriksaan LED; hanya 1 anak dengan LED cepat (> 15mm/jam). Simpulan: Pada studi ini, sebagian besar pasien anak dengan infeksi virus dengue di Manado mempunyai nilai hematokrit normal. Dari 6 pasien yang dilakukan pemeriksaan LED, 1 anak mempunyai hasil LED cepat.Kata kunci: dengue, hematrokrit, laju endap darah.

scholarly journals Diuretic treatment in chronic heart failure

2016 ◽  
Vol 11 (2) ◽  
pp. 155-159
Author(s):  
Camelia C. DIACONU ◽  
◽  
Alice BĂLĂCEANU ◽  
Mihaela Adela IANCU ◽  
◽  
...  
Keyword(s):  
Heart Failure ◽  
Diuretic Therapy ◽  
Medical Science ◽  
Clinical Manifestations ◽  
Public Health Problem ◽  
Developed Countries ◽  
The Body ◽  
Major Public Health Problem ◽  
Important Place ◽  
Central Pillar

Heart failure is a major public health problem in developed countries. Many of the clinical manifestations of heart failure are due to congestion and fluid retention, therefore diuretic therapy occupied for a long time an important place in the management of these patients. All diuretics increase the excretion of water from the body, each of the classes of diuretics achieving this effect in a distinct manner. Given the magnitude of their effect, loop diuretics are the central pillar of diuretic therapy in many patients with heart failure. Resistance to diuretic therapy is one of the management issues for medical science, which is looking for solutions.

scholarly journals Obesity – a closer look to cell mechanisms disfunction

2021 ◽  
Vol 16 (2) ◽  
pp. 129-134
Author(s):  
Elena BĂLĂȘESCU ◽  
◽  
Larisa Diana PANDIA ◽  
Roxana Ioana NEDELCU ◽  
Daniela Adriana ION ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Public Health Problem ◽  
Overweight And Obesity ◽  
The Body ◽  
Biologically Active ◽  
Major Public Health Problem ◽  
Cellular Mechanisms ◽  
Functional Changes ◽  
Long Term Impact ◽  
Visceral Adipose

Obesity is a complex, multifactorial condition, a major public health problem with an increasing prevalence worldwide. Obesity is characterized by an excess of adipose tissue, a low degree of chronic inflammation and disorders in the synthesis of biologically active hormones and peptides which intervene in regulating appetite and energy balance, immunity, insulin sensitivity, angiogenesis, blood pressure, lipid metabolism and homeostasis of the body. The visceral adipose tissue accumulation is accompanied by metabolic disorders that have as a substrate subclinical inflammation and signaling by intracellular pathways that lead to irreversible cellular structural and functional changes. The long-term impact of overweight and obesity translates into shortening life expectancy and disability, due to association with severe comorbidities, such as cardiovascular diseases, diabetes, oncological conditions. Therefore, understanding the cellular mechanisms involved in obesity may facilitate the highlighting of new possible therapeutic targets.

scholarly journals Biopsychosocial Functions of Human Walking and Adherence to Behaviourally Demanding Belief Systems: A Narrative Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Shane O’Mara
Keyword(s):  
Physical Inactivity ◽  
Belief Systems ◽  
Belief System ◽  
Public Health Problem ◽  
Community Support ◽  
The Body ◽  
Human Walking ◽  
Major Public Health Problem ◽  
In The Wild ◽  
Health Promoting

Human walking is a socially embedded and shaped biological adaptation: it frees our hands, makes our minds mobile, and is deeply health promoting. Yet, today, physical inactivity is an unsolved, major public health problem. However, globally, tens of millions of people annually undertake ancient, significant and enduring traditions of physiologically and psychologically arduous walks (pilgrimages) of days-to-weeks extent. Pilgrim walking is a significant human activity requiring weighty commitments of time, action and belief, as well as community support. Paradoxically, human walking is most studied on treadmills, not ‘in the wild’, while mechanistically vital, treadmill studies of walking cannot, in principle, address why humans walk extraordinary distances together to demonstrate their adherence to a behaviourally demanding belief system.Pilgrim walkers provide a rich ‘living laboratory’ bridging humanistic inquiries, to progressive theoretical and empirical investigations of human walking arising from a behaviourally demanding belief system. Pilgrims vary demographically and undertake arduous journeys on precisely mapped routes of tracked, titrated doses and durations on terrain of varying difficulty, allowing investigations from molecular to cultural levels of analysis. Using the reciprocal perspectives of ‘inside→out’ (where processes within brain and body initiate, support and entrain movement) and ‘outside→in’ (where processes in the world beyond brain and body drive activity within brain and body), we examine how pilgrim walking might shape personal, social and transcendental processes, revealing potential mechanisms supporting the body and brain in motion, to how pilgrim walking might offer policy solutions for physical inactivity.

scholarly journals WARAM-I MEDA (GASTRITIS) AND ITS MANAGEMENT FROM UNANI PERSPECTIVE

2021 ◽  
Vol 14 (2) ◽  
Author(s):  
Azma Waseem ◽  
Waseem Ahmad ◽  
Anwar Jamal ◽  
Mohammad Fazil ◽  
Asim Ali Khan
Keyword(s):  
Developing Countries ◽  
Bile Reflux ◽  
Public Health Problem ◽  
Developed Countries ◽  
The Body ◽  
Gastric Ulcers ◽  
Major Public Health Problem ◽  
Two Factors ◽  
Inflammatory Drugs ◽  
Continuous Use

In the present scenario, gastritis still remains a major public health problem that affects the population of both the developed as well as developing countries. More than 50% of the population in developing countries suffers from gastritis, whereas 34.7 % of the population in developed countries had health problems due to gastritis. Main causes of gastritis are infections, stress, continuous use of non steroidal anti-inflammatory drugs, alcohol and bile reflux. Gastritis if remains untreated or undiagnosed causes Quruh-i Meda (gastric ulcers). Prolonged and progressive inflammation results in destruction of gastric mucosa (Atrophic gastritis) and reduction in gastric acid secretions. These two factors are considered as the main risk factors in the pathogenesis of gastric cancer. Unani physicians have given much importance to this disease. In Unani system of medicine, there is elaborated description of gastritis under the heading of Waram-i Meda with causes, symptoms and its effective management. The fundamental principles of Unani treatment of gastritis is to restore the normalcy of the patient, correction of temperament (Mizaj ), humoral balance in the organ and the body, and toning up of the stomach. All these principles are achieved mostly by three modes of treatment i.e. Iaj bil Tadbeer (Regimenal therapy), Ilaj bil Ghiza (Dietotherapy) and Ilaj bil Dawa (Pharmacotherapy). In this review article, Waram-i Meda (gastritis) is elaborated with its type, causes and treatment in Unani perspective with the objective to reduce the burden of gastritis and prevention of complications associated with gastritis.

scholarly journals Growth and Nutritional Status of Adolescent School Girls in a Food Insecure Rural Area of Bangladesh: An Anthropometric Perspective

2014 ◽  
Vol 6 ◽  
pp. 103-111
Author(s):  
Md Azizur Rahman
Keyword(s):  
Nutritional Status ◽  
Adolescent Girls ◽  
Rural Areas ◽  
Public Health Problem ◽  
The Body ◽  
Major Public Health Problem ◽  
Growth Reference ◽  
School Girls ◽  
Rural Adolescent

The present study explored the growth and nutritional status among rural adolescent school girls of food insecure Berasub district of Pabna district in Bangldesh. The study was carried out in rural adolescent school girls of 21 government approved High schools of Berasu district of Pabna district, Bangladesh. Anthropometric and socio-demographic information from 2196 adolescent girls were collected during 2011-2012 academic session. Height and weight were measured using standard procedure and the body mass index (BMI) was calculated. BMI was compared to 2007 WHO growth reference. Height- for-age (HAZ), weight-for-age (WAZ) and BMI-for-age (BMIZ) were used to evaluate stunting, underweight and thinness respectively, based on the National Centre of Heath Statistics (NCHS) < - 2 Z score values. Classification of severity of malnutrition was done based on WHO recommendation. Mean BMI-for-age were less than those of 2007 WHO growth reference for girls at all ages. The overall rate of stunting, underweight and thinness was 33.13%, 28.06% and 17.92% respectively. Based on WHO classification of severity of malnutrition, the overall prevalence of stunting was high (30-39%), whereas those of underweight (≥ 30) and thinness (≥ 15) were very high. The study explores that poor health and nutritional status among the adolescents indicating a major public health problem in food insecure rural areas of Bangladesh. An intensive and comprehensive approach is required to improve the nutritional status of rural adolescent girls of Bangladesh. DOI: http://dx.doi.org/10.3126/hjsa.v6i0.10691   Himalayan Journal of Sociology and Anthropology Vol.6 2014: 103-111

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