scholarly journals In vitro studies of activities of some antifungal agents against Candida albicans ATCC 10231 by the turbidimetric method.

1992 ◽  
Vol 36 (4) ◽  
pp. 898-901 ◽  
Author(s):  
M T Blanco ◽  
C Perez-Giraldo ◽  
J Blanco ◽  
F J Moran ◽  
C Hurtado ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Antifungal Agents ◽  
In Vitro Studies ◽  
Turbidimetric Method

scholarly journals In Vitro Antifungal Activities of a Series of Dication-Substituted Carbazoles, Furans, and Benzimidazoles

1998 ◽  
Vol 42 (10) ◽  
pp. 2503-2510 ◽  
Author(s):  
Maurizio Del Poeta ◽  
Wiley A. Schell ◽  
Christine C. Dykstra ◽  
Susan K. Jones ◽  
Richard R. Tidwell ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Fusarium Solani ◽  
Antifungal Agents ◽  
Antifungal Drugs ◽  
Inhibitory Compounds ◽  
Wide Range ◽  
Fluconazole Resistant ◽  
Resistant Strains

ABSTRACT Aromatic dicationic compounds possess antimicrobial activity against a wide range of eucaryotic pathogens, and in the present study an examination of the structures-functions of a series of compounds against fungi was performed. Sixty-seven dicationic molecules were screened for their inhibitory and fungicidal activities againstCandida albicans and Cryptococcus neoformans. The MICs of a large number of compounds were comparable to those of the standard antifungal drugs amphotericin B and fluconazole. Unlike fluconazole, potent inhibitory compounds in this series were found to have excellent fungicidal activities. The MIC of one of the most potent compounds against C. albicans was 0.39 μg/ml, and it was the most potent compound against C. neoformans (MIC, ≤0.09 μg/ml). Selected compounds were also found to be active againstAspergillus fumigatus, Fusarium solani,Candida species other than C. albicans, and fluconazole-resistant strains of C. albicans and C. neoformans. Since some of these compounds have been safely given to animals, these classes of molecules have the potential to be developed as antifungal agents.

scholarly journals Genotypic variation and antifungal susceptibilities of Candida pelliculosa clinical isolates

2005 ◽  
Vol 54 (3) ◽  
pp. 279-285 ◽  
Author(s):  
F Barchiesi ◽  
A M Tortorano ◽  
L Falconi Di Francesco ◽  
A Rigoni ◽  
A Giacometti ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Drug Therapy ◽  
Amphotericin B ◽  
Antifungal Agents ◽  
Yeast Species ◽  
Genotypic Variation ◽  
Optimal Drug ◽  
Typing Methods ◽  
Dna Types

At the Istituto Ricovero Cura Carattere Scientifico, Ospedale Maggiore di Milano, Italy, Candida pelliculosa accounted for 3.3 and 4.4 % of all Candida species other than Candida albicans collected during 1996 and 1998, respectively. Genetic variability was investigated by electrophoretic karyotyping and inter-repeat PCR, and the susceptibility to five antifungal agents of 46 strains isolated from 37 patients during these 2 years was determined. Combination of the two typing methods yielded 14 different DNA types. Although the majority of DNA types were randomly distributed among different units, one DNA type was significantly more common in patients hospitalized in a given unit compared with those from other wards (P = 0.034), whereas another DNA type was more frequently isolated in patients hospitalized during 1996 than in those hospitalized during 1998 (P = 0.002). Fluconazole, itraconazole and posaconazole MIC90 values were 16, 1 and 4 μg ml−1, respectively. All isolates but three were susceptible in vitro to flucytosine. All isolates were susceptible in vitro to amphotericin B. These data suggest that there are possible relationships among strains of C. pelliculosa, wards and time of isolation. Amphotericin B seems to be the optimal drug therapy in infections due to this yeast species.

In-vitro studies with four new antifungal agents: BAY n7133, bifonazole (BAY h 4502), ICI 153,066 and Ro 14-4767/002

1984 ◽  
Vol 22 (1) ◽  
pp. 7-15 ◽  
Author(s):  
Smith Shadomy ◽  
Ana Espinel-Ingroff ◽  
Thomas M. Kerkering
Keyword(s):  
Antifungal Agents ◽  
In Vitro Studies

scholarly journals In Vitro Pharmacodynamic Properties of Three Antifungal Agents against Preformed Candida albicans Biofilms Determined by Time-Kill Studies

2002 ◽  
Vol 46 (11) ◽  
pp. 3634-3636 ◽  
Author(s):  
Gordon Ramage ◽  
Kacy VandeWalle ◽  
Stefano P. Bachmann ◽  
Brian L. Wickes ◽  
José L. López-Ribot
Keyword(s):  
Candida Albicans ◽  
Amphotericin B ◽  
Antifungal Agents ◽  
Pharmacokinetic Properties ◽  
Time Kill ◽  
Candida Albicans Biofilms

ABSTRACT We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with ≥99% killing at physiological concentrations.

In vitro studies of elution of fluconazole, chlorhexidine and combination of two drugs from self-cured acrylic and effect of eluates upon growth of Candida albicans

2009 ◽  
Vol 13 (4) ◽  
pp. 448-454
Author(s):  
W. M. Amin ◽  
M. A. Alawi ◽  
R. M. Darwish ◽  
M. H. Al-Ali ◽  
N. A. Salim ◽  
...  
Keyword(s):  
Candida Albicans ◽  
In Vitro Studies

Effect of curcumin-mediated photodynamic therapy on Streptococcus mutans and Candida albicans: A systematic review of in vitro studies

2019 ◽  
Vol 27 ◽  
pp. 455-461 ◽  
Author(s):  
Daniele de Cassia Rodrigues Picco ◽  
Leonardo Lobo Ribeiro Cavalcante ◽  
Rayana Longo Bighetti Trevisan ◽  
Aline Evangelista Souza-Gabriel ◽  
Maria Cristina Borsatto ◽  
...  
Keyword(s):  
Systematic Review ◽  
Candida Albicans ◽  
Photodynamic Therapy ◽  
Streptococcus Mutans ◽  
In Vitro Studies

scholarly journals Virulence of the Fungal Pathogen Candida albicans Requires the Five Isoforms of Protein Mannosyltransferases

2005 ◽  
Vol 73 (8) ◽  
pp. 4571-4580 ◽  
Author(s):  
Mahmoud Rouabhia ◽  
Martin Schaller ◽  
Cristina Corbucci ◽  
Anna Vecchiarelli ◽  
Stephan K.-H. Prill ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Mouse Model ◽  
Fungal Pathogen ◽  
Antifungal Agents ◽  
Three Dimensional ◽  
Secretory Proteins ◽  
In Vitro Growth ◽  
Specific Host ◽  
Three Dimensional Models

ABSTRACT The PMT gene family in Candida albicans encodes five isoforms of protein mannosyltransferases (Pmt proteins Pmt1p, Pmt2p, Pmt4p, Pmt5p, and Pmt6p) that initiate O mannosylation of secretory proteins. We compared virulence characteristics of pmt mutants in two complex, three-dimensional models of localized candidiasis, using reconstituted human epithelium (RHE) and engineered human oral mucosa (EHOM); in addition, mutants were tested in a mouse model of hematogenously disseminated candidiasis (HDC). All pmt mutants showed attenuated virulence in the HDC model and at least one model of localized candidiasis. The pmt5 mutant, which lacks in vitro growth phenotypes, was less virulent in the EHOM and HDC assays but had no consistent phenotype in the RHE assay. In contrast, the pmt4 and pmt6 mutants were less virulent in the RHE and HDC assays but not in the EHOM assay. The results stress the contribution of all Pmt isoforms to the virulence of C. albicans and suggest that the importance of individual Pmt isoforms may differ in specific host niches. We propose that Pmt proteins may be suitable targets for future novel classes of antifungal agents.

scholarly journals The effects of antifungal agents on the morphogenetic transformation by Candida albicans in vitro

1996 ◽  
Vol 38 (4) ◽  
pp. 579-587 ◽  
Author(s):  
Stephen Hawser ◽  
Maura Francolini ◽  
Khalid Islam
Keyword(s):  
Candida Albicans ◽  
Antifungal Agents
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