scholarly journals Correlation of various in vitro testing methods with clinical outcomes in patients with Bacteroides fragilis group infections treated with cefoxitin: a retrospective analysis.

1992 ◽  
Vol 36 (3) ◽  
pp. 540-544 ◽  
Author(s):  
D R Snydman ◽  
G J Cuchural ◽  
L McDermott ◽  
M Gill
Keyword(s):  
Retrospective Analysis ◽  
Clinical Outcomes ◽  
Bacteroides Fragilis ◽  
In Vitro Testing ◽  
Testing Methods ◽  
Bacteroides Fragilis Group

Evaluation of 4 sensitizations in vitro testing methods for botanical mixtures: Proof-of-concept

2012 ◽  
Vol 211 ◽  
pp. S112-S113
Author(s):  
E. Andres ◽  
V.M. Sá-Rocha ◽  
E.L. Roggen ◽  
E. Corsini ◽  
S. Gibbs ◽  
...  
Keyword(s):  
In Vitro Testing ◽  
Proof Of Concept ◽  
Testing Methods

scholarly journals Effect of pH on in vitro antimicrobial susceptibility of the Bacteroides fragilis group.

1997 ◽  
Vol 41 (9) ◽  
pp. 2047-2049 ◽  
Author(s):  
M E Falagas ◽  
L McDermott ◽  
D R Snydman
Keyword(s):  
Antimicrobial Susceptibility ◽  
Ph Effect ◽  
Geometric Mean ◽  
Bacteroides Fragilis ◽  
Acidic Ph ◽  
Effect Of Ph ◽  
Bacteroides Fragilis Group ◽  
Group Species

We studied the effect of pH (7.1, 6.3, and 5.8) on the in vitro susceptibilities of 59 isolates of Bacteroides fragilis and 60 isolates of other B. fragilis group species to trovafloxacin, ciprofloxacin, clindamycin, ampicillin-sulbactam, piperacillin-tazobactam, imipenem, and meropenem. For each agent tested the geometric mean MIC was highest at pH 5.8, intermediate at pH 6.3, and lowest at pH 7.1. The magnitude of the pH effect varied greatly among different antibiotics. These data show that an acidic pH decreases the in vitro susceptibilities of the B. fragilis group to several antibiotics.

scholarly journals Comparative in vitro activities of trovafloxacin (CP 99,219) and other antimicrobials against clinically significant anaerobes.

1997 ◽  
Vol 41 (2) ◽  
pp. 484-487 ◽  
Author(s):  
K E Aldridge ◽  
D Ashcraft ◽  
K A Bowman
Keyword(s):  
Bacteroides Fragilis ◽  
Bacteroides Fragilis Group ◽  
Clinically Significant

A total of 590 strains of clinically important anaerobes were tested to determine their susceptibility to trovafloxacin. Overall, trovafloxacin had a mode MIC of 0.25 micrograms/ml and a MIC at which 90% of the isolates were inhibited of 1 micrograms/ml and had activity comparable to that of metronidazole. Trovafloxacin was 8-, 8-, 16-, 32-, and 64-fold more active than ampicillin-sulbactam, clindamycin, ciprofloxacin, cefoxitin, and cefotetan, respectively. Of the Bacteroides fragilis group, 97% of the isolates were inhibited by trovafloxacin at 21 micrograms/ml, and trovafloxacin was more active than ciprofloxacin, cefoxitin, cefotetan, ampicillin-sulbactam, and clindamycin against Clostridium, Fusobacterium, Porphyromonas, and Prevotella strains.

scholarly journals In Vitro Activity of Tedizolid Compared to Linezolid and Five Other Antimicrobial Agents against 332 Anaerobic Isolates, Including Bacteroides fragilis Group, Prevotella, Porphyromonas, and Veillonella Species

2020 ◽  
Vol 64 (9) ◽  
Author(s):  
Ellie J. C. Goldstein ◽  
C. Vreni Merriam ◽  
Diane M. Citron
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Agents ◽  
Bacteroides Fragilis ◽  
Vitro Activity ◽  
Mixed Infections ◽  
In Vitro Activity ◽  
Content Type ◽  
Bacteroides Fragilis Group ◽  
Group Species

ABSTRACT Tedizolid’s anaerobic activity is unappreciated. In this study, it was active against all 332 anaerobic isolates tested at ≤2 μg/ml except Bilophila wadsworthia and was more active than linezolid against Bacteroides fragilis group species (MIC90, 1 μg/ml versus 2 to 4 μg/ml). Tedizolid was active against Gram-positive anaerobes (MIC90 for clostridia, 0.25 to 1 μg/ml; MIC90 for anaerobic cocci, ≤0.06 to 0.25 μg/ml). Our data coupled with clinical reports indicate that clinicians should consider its use in mixed infections where Staphylococcus aureus and anaerobes are involved.

scholarly journals Evaluation of Different in Vitro Testing Methods for Mechanical Properties of Veneer Ceramics/ Евалуација На Тестовите In Vitro За Одредување На Механичките Особини На Порцеланските Маси За Фасетирање

PRILOZI ◽  
2015 ◽  
Vol 36 (1) ◽  
pp. 225-230 ◽  
Author(s):  
Aneta Mijoska ◽  
Mirjana Popovska
Keyword(s):  
Flexural Strength ◽  
Mechanical Characteristics ◽  
Testing Machine ◽  
In Vitro Testing ◽  
Biaxial Test ◽  
Testing Methods ◽  
Dental Ceramic ◽  
Universal Testing ◽  
Biaxial Tests

Abstract Metal-ceramic and all-ceramic prosthetic restorations in the patient mouth are often damaged by esthetic and functional problems that reduce their success and longevity. Аim: To evaluate methods for testing mechanical characteristics of dental ceramics through analysis of different testing methods. Material and methods: Dental ceramic materials are tested with in vivo and in vitro methods for their most important mechanical characteristics: hardness, toughness, flexural strength and abrasion. In vitro testing methods are faster and more efficient, without subjective factors from the patient according to ISO standards. Testing is done with universal testing machines, like Zwick 1445, Universal Testing Machine (Zwick DmbH & Co.KG, Ulm, Germany), Instron 4302 (Instron Corporation, England), MTS Sintech ReNew 1123 or in oral chewing simulators. Results: According to the testing results, flexure strength is one of the most important characteristic of the dental ceramic to be tested, by the uniaxial and biaxial tests. Uniaxial tests three-point and four-point flexure are not most appropriate because the main stress on the lower side of the tested specimens is tension that causes beginning fractures at the places with superficial flow. Uniaxial results for flexural strength are lower than actual force, while with biaxial test defects and flows on the edges of tested specimens are not directly loaded. Conclusion: Biaxial flexural method has advantages over uniaxial because of real strength results, but also for simple shape and preparing of the testing specimens.

scholarly journals In Vitro Activities of MK-0826 and 16 Other Antimicrobials against Bacteroides fragilis Group Strains

2001 ◽  
Vol 45 (8) ◽  
pp. 2372-2374 ◽  
Author(s):  
Carmen Betriu ◽  
Ana Sánchez ◽  
Marı́a Luisa Palau ◽  
Marı́a Gómez ◽  
Juan J. Picazo
Keyword(s):  
Bacteroides Fragilis ◽  
Excellent Activity ◽  
Bacteroides Fragilis Group ◽  
Anaerobic Infections

ABSTRACT The activity of MK-0826, a new carbapenem, against 309Bacteroides fragilis group strains was investigated and compared with that of 11 other β-lactam and 5 non-β-lactam agents. MK-0826 showed excellent activity (MICs ranged from ≤0.06 to 4 μg/ml). The new carbapenem may be useful in the treatment of mixed anaerobic infections involving B. fragilis group strains.

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