scholarly journals Pharmacokinetics and inflammatory fluid penetration of cefpodoxime proxetil in volunteers.

1990 ◽  
Vol 34 (2) ◽  
pp. 232-234 ◽  
Author(s):  
P O'Neill ◽  
K Nye ◽  
G Douce ◽  
J Andrews ◽  
R Wise
Keyword(s):  
Cefpodoxime Proxetil ◽  
Fluid Penetration

Third-Generation and Investigational Cephalosporins: I. Structure-Activity Relationships and Pharmacokinetic Review

1983 ◽  
Vol 17 (7-8) ◽  
pp. 507-515 ◽  
Author(s):  
Pamela Garzone ◽  
James Lyon ◽  
Victor L. Yu
Keyword(s):  
Classification Scheme ◽  
Third Generation ◽  
Serum Concentrations ◽  
New Agents ◽  
The Third ◽  
Structure Activity ◽  
Pharmacokinetic Properties ◽  
Fluid Penetration ◽  
Third Generation Cephalosporins ◽  
Antibacterial Spectrum

The structure-relationships and pharmacokinetic properties of the new second- and third-generation cephalosporins are reviewed. The new second-generation cephalosporins include ceforanide, cefotiam, and cefuroxime. The third-generation cephalosporins include cefmenoxime, cefoperazone, cefotaxime, cefsulodin, ceftazidime, ceftizoxime, ceftriaxone, and moxalactam. These new cephalosporins are semisynthetic analogs with different chemical substitutions on a 7-aminocephalosporanic nucleus. As a result of these chemical modifications, improvements in the antibacterial spectrum as well as pharmacokinetic properties have occurred. In general, the new cephalosporins have longer half-lives, higher and prolonged serum concentrations, and increased cerebrospinal fluid penetration. Selected cephalosporins also have increased biliary tract concentrations. A classification scheme for these new agents, based on generation and susceptibility to Pseudomonas aeruginosa, is presented.

The bioavailability of cefpodoxime proxetil tablets relative to an oral solution

1995 ◽  
Vol 16 (4) ◽  
pp. 295-302 ◽  
Author(s):  
Marie T. Borin ◽  
Kristi K. Forbes ◽  
George S. Hughes
Keyword(s):  
Oral Solution ◽  
Cefpodoxime Proxetil

HPTLC Determination of Cefpodoxime Proxetil in Formulations

2007 ◽  
Vol 66 (11-12) ◽  
pp. 905-908 ◽  
Author(s):  
Abhijit A. Date ◽  
Mangal S. Nagarsenker
Keyword(s):  
Cefpodoxime Proxetil

Comparison of Cefpodoxime Proxetil and Cefixime in the Treatment of Acute Otitis Media in Infants and Children

PEDIATRICS ◽  
1994 ◽  
Vol 94 (6) ◽  
pp. 847-852
Author(s):  
Basim I. Asmar ◽  
Adnan S. Dajani ◽  
Mark A. Del Beccaro ◽  
Paul M. Mendelman ◽  
Keyword(s):  
Otitis Media ◽  
Acute Otitis Media ◽  
Drug Efficacy ◽  
Oral Suspension ◽  
Suppurative Otitis Media ◽  
Once Daily ◽  
Cefpodoxime Proxetil ◽  
Long Term Follow Up ◽  
Cure Rates

Objective. To compare the use of once-a-day cefpodoxime proxetil to once-a-day cefixime in the treatment of acute suppurative otitis media. Design. Randomized, multicenter, investigator-blinded. Setting. Outpatient. Patients. A total of 368 patients (age 2 months to 17 years) were randomized to receive either cefpodoxime or cefixime in a 2:1 ratio (245 cefpodoxime, 123 cefixime); 236 patients (155 cefpodoxime, 81 cefixime) were evaluable for drug efficacy. Interventions. Patients received either cefpodoxime proxetil oral suspension (10 mg/kg/day, once daily for 10 days) or cefixime oral suspension (8 mg/kg/day, once daily for 10 days). Main outcome measures. Clinical evaluations were performed before treatment (study day 1), at an interim visit (study day 3 through 6), at the end of therapy (study day 12 through 15), and at final follow-up (study day 25 through 38). Microbiologic evaluations were performed at enrollment and whenever appropriate thereafter. Results. End-of-therapy clinical cure rates in evaluable patients were 56% for the cefpodoxime group and 54% for the cefixime group. Clinical improvement rates were 27% for both groups. Clinical response rates were not significantly different between treatment groups (P = .541; 95% confidence interval = -8.1%, 15.2%). At long-term follow-up, 17% of patients in the cefpodoxime group and 20% in the cefixime group had a recurrence of infection. Drug-related adverse events (eg, diarrhea, diaper rash, vomiting, rash) occurred in 23.3% of cefpodoxime-treated patients and 17.9% of cefixime-treated patients (P = .282). Conclusions. These findings suggest that cefpo-doxime proxetil administered once daily is as effective and safe as cefixime given once daily in the treatment of acute suppurative otitis media in pediatric patients.

Geomechanical aspects of induced microseismicity during CO2 injection in Illinois Basin

2021 ◽  
Vol 40 (11) ◽  
pp. 823-830
Author(s):  
Nikita Bondarenko ◽  
Sherilyn Williams-Stroud ◽  
Jared Freiburg ◽  
Roman Makhnenko
Keyword(s):  
Oil Field ◽  
Co2 Injection ◽  
Low Permeability ◽  
Illinois Basin ◽  
Petrographic Analysis ◽  
Flow Properties ◽  
Geomechanical Characterization ◽  
Fluid Penetration ◽  
Geophysical Log

Carbon sequestration activities are increasing in a global effort to mitigate the effects of greenhouse gas emissions on the climate. Injection of wastewater and oil-field fluids is known to induce seismic activity. This makes it important to understand how that risk relates to CO2 injection. Injection of supercritical CO2 into the Cambrian Mt. Simon sandstone in Illinois Basin induced microseismicity that was observed below the reservoir, primarily in the Precambrian crystalline basement. Geomechanical and flow properties of rock samples from the involved formations were measured in the laboratory and compared with geophysical log data and petrographic analysis. The controlling factors for induced microseismicity in the basement seem to be the hydraulic connection between the reservoir and basement rock and reactivation of pre-existing faults or fractures in the basement. Additionally, the presence of a laterally continuous low-permeability layer between reservoir and basement may have prevented downward migration of pore pressure and reactivation of critically stressed planes of weakness in the basement. Results of the geomechanical characterization of this intermediate layer indicate that it may act as an effective barrier for fluid penetration into the basement and that induced microseismicity is likely to be controlled by the pre-existing system of faults. This is because the intact material is not expected to fail under the reservoir stress conditions.

Sign in / Sign up

Export Citation Format

Share Document