scholarly journals In vitro activities of ureidopenicillins alone and in combination with amikacin and three cephalosporin antibiotics.

1984 ◽  
Vol 26 (2) ◽  
pp. 256-259 ◽  
Author(s):  
J A Moody ◽  
L R Peterson ◽  
D N Gerding
Keyword(s):  
Cephalosporin Antibiotics

Nimbolide from Azadirachta indica and its derivatives plus first-generation cephalosporin antibiotics: a novel drug combination for wound-infecting pathogens

RSC Advances ◽  
2015 ◽  
Vol 5 (109) ◽  
pp. 89503-89514 ◽  
Author(s):  
S. R. Dhanya ◽  
S. Nishanth Kumar ◽  
Vandana Sankar ◽  
K. G. Raghu ◽  
B. S. Dileep Kumar ◽  
...  
Keyword(s):  
Azadirachta Indica ◽  
Drug Combination ◽  
First Generation ◽  
Bacterial Pathogens ◽  
Generation Cephalosporin ◽  
Amide Derivatives ◽  
Cephalosporin Antibiotics ◽  
Novel Drug ◽  
Derivatives Of

We evaluate the in vitro efficacy of nimbolide, desacetylnimbin, and the amide derivatives of nimbolide in combination with first-generation cephalosporin antibiotics against major wound-associated bacterial pathogens.

scholarly journals Cephalosporin Antibiotics Specifically Enhance Conventional Chemotherapy in Nasopharyngeal Cancer

2020 ◽  
Author(s):  
Xiao-Qiong He ◽  
Qian Yao ◽  
Zhong Yu Song ◽  
Dan Fan ◽  
Yu Tong You ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Cancer Cells ◽  
Nasopharyngeal Cancer ◽  
Combination Group ◽  
Conventional Chemotherapy ◽  
Microarray Gene Expression ◽  
Anticancer Efficacy ◽  
Cephalosporin Antibiotics

Abstract Background: Cephalosporin antibiotics can drastically upregulate the expression of HMOX1 in nasopharyngeal carcinoma cells. HMOX1 has dual role in cancer cells, and is involved in chemoresistance. Cephalosporin antibiotics are widely used in the treatment of bacteria infectious diseases in cancer patients. Whether they affect the efficacy of chemotherapy is unknown. Methods: Comparisons between cefotaxime and the combination of cefotaxime and cisplatin were carried out throughout the study. Cell viability was detected by MTT method. Influence on clone formation of cancer cells was investigated by plate clone formation assay. The in vivo anticancer effect was determined via cancer xenograft in mice. Flow cytometry analysis was used to detect the apoptosis. Microarray gene expression profiling was analyzed using Gene Ontology analysis, and the differential genes were validated by RT-qPCR. Results: Cefotaxime specifically, selectively and synergistically enhanced the anticancer efficacy of cisplatin in nasopharyngeal carcinoma both in vitro and in vivo without increasing the toxicity, but it inhibited the cytotoxic effects of cisplatin in other cancers. Combination of cefotaxime and cisplatin significantly regulated 5 genes in direction favoring the enhancement of anticancer efficacy; of which, THBS1 and LAPTM5 were upregulated; PPP3CB, STAG1 and NCOA5 were downregulated jointly. HMOX1 contributes to the anticancer efficacy in combination group. Upregulated genes significantly modulated 18 apoptotic pathways, downregulated genes mainly affected assembly of genetic materials. Conclusion: Cephalosporin antibiotics are excellent and safe sensitizers of conventional chemotherapy in the treatment of nasopharyngeal carcinoma, but should be carefully used in other cancers.

scholarly journals Comparative In Vitro Activity of Five Cephalosporin Antibiotics Against Salmonellae

1978 ◽  
Vol 13 (1) ◽  
pp. 134-136 ◽  
Author(s):  
L. J. Strausbaugh ◽  
I. A. Mikhail ◽  
D. C. Edman
Keyword(s):  
Vitro Activity ◽  
In Vitro Activity ◽  
Cephalosporin Antibiotics

Ultrastructural Investigations of the Contractile Filaments of Amoebae

1974 ◽  
Vol 32 ◽  
pp. 188-189
Author(s):  
P.L. Moore
Keyword(s):  
Cytoplasmic Streaming ◽  
Three Dimensional ◽  
Freeze Fracture ◽  
Amoeboid Movement ◽  
Different Types ◽  
Chemical Conditions ◽  
Complete Interpretation

Previous freeze fracture results on the intact giant, amoeba Chaos carolinensis indicated the presence of a fibrillar arrangement of filaments within the cytoplasm. A complete interpretation of the three dimensional ultrastructure of these structures, and their possible role in amoeboid movement was not possible, since comparable results could not be obtained with conventional fixation of intact amoebae. Progress in interpreting the freeze fracture images of amoebae required a more thorough understanding of the different types of filaments present in amoebae, and of the ways in which they could be organized while remaining functional.The recent development of a calcium sensitive, demembranated, amoeboid model of Chaos carolinensis has made it possible to achieve a better understanding of such functional arrangements of amoeboid filaments. In these models the motility of demembranated cytoplasm can be controlled in vitro, and the chemical conditions necessary for contractility, and cytoplasmic streaming can be investigated. It is clear from these studies that “fibrils” exist in amoeboid models, and that they are capable of contracting along their length under conditions similar to those which cause contraction in vertebrate muscles.

In Vitro Induction of Crystals of MT Protein by Vinblastine-Colcemid in Mouse Spermatids

1974 ◽  
Vol 32 ◽  
pp. 132-133
Author(s):  
John J. Wolosewick ◽  
John H. D. Bryan
Keyword(s):  
Endoplasmic Reticulum ◽  
Smooth Endoplasmic Reticulum ◽  
Nuclear Ring ◽  
Rough Er ◽  
Distal Direction ◽  
In Vitro Induction

Early in spermiogenesis the manchette is rapidly assembled in a distal direction from the nuclear-ring-densities. The association of vesicles of smooth endoplasmic reticulum (SER) and the manchette microtubules (MTS) has been reported. In the mouse, osmophilic densities at the distal ends of the manchette are the organizing centers (MTOCS), and are associated with the SER. Rapid MT assembly and the lack of rough ER suggests that there is an existing pool of MT protein. Colcemid potentiates the reaction of vinblastine with tubulin and was used in this investigation to detect this protein.

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